This section shows a list of key manuscripts on data harmonization, statistical analysis and Ethical, Legal and Social Implications (ELSI) generated by Maelstrom Research investigators and collaborators.

General harmonization publications

  • Fortier I, Raina P, Van den Heuvel ER, Griffith LE, Craig C, Saliba M, Doiron D, Stolk RP, Knoppers BM, Ferretti V, Granda P. Maelstrom Research guidelines for rigorous retrospective data harmonization. Int J Epidemiol (2017) 46 (1): 103-105. Pubmed ID: 27272186 View article
  • Doiron D, Burton P, Marcon Y, Wolffenbuttel BH, Perola M, Stolk RP, Foco L, Minelli C, Waldenberger M, Holle R, Kvaloy K, Hillege HL, Tasse AM, Ferretti V, Fortier I, Data harmonization and federated analysis of population-based studies: the BioSHaRE project. Emerging Themes In Epidemiology, 2013. 10(1): p.12. Pubmed ID: 24257327 View article
  • Doiron D, Raina P, Ferretti V, L’Heureux F, Fortier I, Facilitating Collaborative Research: Implementing a Platform Supporting Data Harmonization and Pooling. Norwegian Journal of Epidemiology, 2012. 21(2): p. 221-224. View article
  • Fortier I, Doiron D, Wolfson C, Raina P, Harmonizing data for collaborative research on aging: why should we foster such an agenda? Can J Aging, 2012. 31(1): p. 95-9. Pubmed ID: 22373784 View article
  • Fortier I, Doiron D, Burton P, Raina P, Invited commentary: consolidating data harmonization--how to obtain quality and applicability? Am J Epidemiol, 2011. 174(3): p. 261-4; author reply 265-6. Pubmed ID: 21749975 View article
  • Fortier I, Doiron D, Little J, Ferretti V, L'Heureux F, Stolk RP, Knoppers BM, Hudson TJ, Burton PR, International Harmonization Initiative, Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J Epidemiol, 2011. 40(5): p. 1314-28. Pubmed ID: 21804097 View article
  • Fortier I, Burton PR, Robson PJ, Ferretti V, Little J, L'Heureux F, Deschenes M, Knoppers BM, Doiron D, Keers JC, Linksted P, Harris JR, Lachance G, Boileau C, Pedersen NL, Hamilton CM, Hveem K, Borugian MJ, Gallagher RP, McLaughlin J, Parker L, Potter JD, Gallacher J, Kaaks R, Liu B, Sprosen T, Vilain A, Atkinson SA, Rengifo A, Morton R, Metspalu A, Wichmann HE, Tremblay M, Chisholm RL, Garcia-Montero A, Hillege H, Litton JE, Palmer LJ, Perola M, Wolffenbuttel BH, Peltonen L, and Hudson TJ, Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. Int J Epidemiol, 2010. 39(5): p. 1383-93. Pubmed ID: 20813861 View article

Statistical publications

  • Van den Heuvel ER, Griffith LE. Statistical harmonization methods in individual participants data meta-analysis are highly needed. Biometrics & Biostatistics International Journal, 2016, 3(3):1-2. View article
  • Griffith LE, van den Heuvel E, Raina P, Fortier I, Sohel N, Hofer SM, Payette H, Wolfson C, Belleville S, Kenny M, Doiron D. Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures. Am J Epidemiol 2016. 184(10): 770–778. Pubmed ID: 27769990 View article
  • Gaye A, Burton TWY, Burton PR. ESPRESSO: taking into account assessment errors on outcome and exposures in power analysis for association studies. Bioinformatics 2015. 31(16): 2691–2696. Pubmed ID : 25908791 View article
  • Gaye A, Marcon Y, Isaeva J, LaFlamme P, Turner A, Jones EM, Minion J, Boyd AW, Newby CJ, Nuotio ML, Wilson R, Butters O, Murtagh B, Demir I, Doiron D, Giepmans L, Wallace SE, Budin-Ljøsne I, Oliver Schmidt C, Boffetta P, Boniol M, Bota M, Carter KW, deKlerk N, Dibben C, Francis RW, Hiekkalinna T, Hveem K, Kvaløy K, Millar S, Perry IJ, Peters A, Phillips CM, Popham F, Raab G, Reischl E, Sheehan N, Waldenberger M, Perola M, van den Heuvel E, Macleod J, Knoppers BM, Stolk RP, Fortier I, Harris JR, Woffenbuttel BH, Murtagh MJ, Ferretti V, Burton PR. DataSHIELD: taking the analysis to the data, not the data to the analysis.Int J Epidemiol. 2014 Sep 26. pii: dyu188. Pubmed ID: 25261970 View article
  • Griffith LE, van den Heuvel E, Fortier I, Sohel N, Hofer SM, Payette H, Wolfson C, Belleville S, Kenny M, Doiron D, Raina P, Statistical approaches to harmonize data on cognitive measures in systematic reviews are rarely reported, Journal of Clinical Epidemiology, 2014 pii: S0895-4356. Pubmed ID: 25497980 View article
  • Griffith L, van den Heuvel E, Fortier I, Hofer S, Raina P, Sohel N, Payette H, Wolfson C, Belleville S. Harmonization of Cognitive Measures in Individual Participant Data and Aggregate Data Meta-Analysis (March 2013) AHRQ Publication No. 13-EHC040-EF Pubmed ID: 23617017 View article
  • Wolfson M, Wallace SE, Masca N, Rowe G, Sheehan NA, Ferretti V, LaFlamme P, Tobin MD, Macleod J, Little J, Fortier I, Knoppers BM, and Burton PR, DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled analysis of individual-level data without sharing the data. Int J Epidemiol, 2010. 39(5): p. 1372-82. Pubmed ID: 20630989 View article
  • Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliot P, Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol, 2009. 38(1): p. 263-73. Pubmed ID: 18676414 View article

ELSI publications

  • Budin-Ljøsne I, Burton P, Isaeva J, Gaye A, Turner A, Murtagh MJ, Wallace S, Ferretti V, Harris JR. DataSHIELD: An Ethically Robust Solution to Multiple-Site Individual-Level Data Analysis, Public Health Genomics, 2015. 18(2):87-96 Pubmed ID: 25532061 View article
  • Wallace SE, Gaye A, Shoush O, Burton PR. Protecting Personal Data in Epidemiological Research: DataSHIELD and UK Law​, Journal of Clinical Epidemiology, Public Health Genomics, 2014. 17(3):149-57 Pubmed ID: 24685519 View article