Advanced Cognitive Training for Independent and Vital Elderly
The primary objective of the trial is to test the effects of three distinct cognitive interventions on primary outcome measures of cognitively demanding daily activities related to living independently (e.g., food preparation, driving, medication use, financial management). Each of the three interventions is targeted at improving memory, reasoning, or speed of information processing.
A secondary objective of the trial is to investigate the process by which the interventions affect the primary outcomes, including exploring whether a set of proximal outcomes (measures of the basic abilities being trained) serve as mediators of the effects of cognitive training on the primary outcome measures.
Overview
- Acronym
- ACTIVE
- Website
- ACTIVE
- Investigators
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- Contacts
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General Design
- Study design
- Clinical trial
- Start - End Year
- 1998 - 2008
- General Information on Follow Up (profile, frequency)
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Outcome assessments were conducted immediately and 1, 2, 3, 5 and 10 years after the intervention.
- Recruitment Target
-
- Individuals
- Number of Participants
- 2,832
- Supplementary information about number of participants
-
Baseline and Intervention: 2832 participants
Immediate post-test: 2561 participants
Booster: 1113 participants
1 year: 2336 participants
2 years: 2244 participants
Booster at 3 year: 1113 participants
3 years: 1879 participants
5 years: 1879 participants
10 years: 1220 participants
- Supplementary Information
-
ACTIVE is a multisite, randomized, controlled clinical trial. Participants were randomly assigned to one of three intervention groups (memory, reasoning, or speed-of-processing training) or a no-contact control group.
Access
Availability of data and biosamples
Possible Access to Data | |
Possible Access to Biosamples | |
Other |
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Marker Papers
Rebok GW, Ball K, Guey LT, Jones RN, et al. Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. 2014; 62(1): 16-24.
PUBMED 24417410Timeline
Populations
Selection Criteria
- Minimum age
-
65
- Countries
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- United States of America
- Health Status
-
- Exclusions: * already experienced substantial cognitive decline * had a self-reported diagnosis of Alzheimer disease * had already experienced substantial functional decline * had medical conditions that would predispose them to imminent functional decline or death * had severe losses in vision, hearing, or communicative ability that would sufficiently impair performance to make participation impossible
- Other Criteria
- Exclusions: * younger than 65 years at screening * had recent cognitive training * were unavailable during the testing and intervention phases of the study * had severe losses in vision, hearing, or communicative ability that would sufficiently impair performance to make participation impossible
- Supplementary Information about selection criteria
-
The individuals in this group received a ten-session training intervention on reasoning.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Selected sample
- Supplementary Information
-
The participants were enrolled across 6 field sites using a variety of sampling frames and recruitment strategies. Participants were recruited through state driver’s licenses and identification card registries, medical clinic rosters, senior center and community organization rosters, senior housing sites, local churches, and rosters of assistance and service programs for low-income elderly persons.
Sample Size
- Number of Participants
- 705
- Supplementary Information about selection criteria
-
Baseline and Intervention: 705 participants
Immediate post-test: 629 participants
Booster: 371 participants
1 year: 566 participants
2 years: 555 participants
Booster at 3 year: 371 participants
3 years: 469 participants
5 years: 469 participants
10 years: 316 participants
Data Collection Events
# | Name | Data sources | Data sources - Biosamples | Start | End |
---|---|---|---|---|---|
0 | ACTIVE - Immediate post-test |
|
1998 (June) | 2000 (January) | |
1 | ACTIVE - Intervention |
|
1998 (June) | 2000 (January) | |
2 | ACTIVE - Baseline |
|
1998 (June) | 2000 (January) | |
3 | ACTIVE - Booster at 1 year |
|
1999 (May) | 2000 (December) | |
4 | ACTIVE - 1 year |
|
1999 (May) | 2001 (January) | |
5 | ACTIVE - 2 years |
|
2000 (May) | 2001 (December) | |
6 | ACTIVE - 3 years |
|
2001 (May) | 2002 (December) | |
7 | ACTIVE - Booster at 3 years |
|
2001 (May) | 2002 (December) | |
8 | ACTIVE - 5 years |
|
2003 (May) | 2004 (December) | |
9 | ACTIVE - 10 years |
|
2008 (May) | 2009 (December) |
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Health Status
-
- Exclusions: * had already experienced substantial cognitive decline * had a self-reported diagnosis of Alzheimer disease * had already experienced substantial functional decline * had medical conditions that would predispose them to imminent functional decline or death * had severe losses in vision, hearing, or communicative ability that would sufficiently impair performance to make participation impossible
- Other Criteria
- Exclusions: * younger than 65 years at screening * had recent cognitive training * were unavailable during the testing and intervention phases of the study
- Supplementary Information about selection criteria
-
The individuals in this group received a ten-session training intervention on memory.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Selected sample
- Supplementary Information
-
Participants were enrolled across 6 field sites using a variety of sampling frames and recruitment strategies. Participants were recruited through state driver’s licenses and identification card registries, medical clinic rosters, senior center and community organization rosters, senior housing sites, local churches, and rosters of assistance and service programs for low-income elderly persons.
Sample Size
- Number of Participants
- 711
- Supplementary Information about selection criteria
-
Baseline and Intervention: 711 participants
Immediate post-test: 640 participants
Booster: 372 participants
1 year: 585 participants
2 years: 563 participants
Booster at 3 year: 372 participants
3 years: 472 participants
5 years: 472 participants
10 years: 300 participants
Data Collection Events
# | Name | Data sources | Data sources - Biosamples | Start | End |
---|---|---|---|---|---|
0 | ACTIVE - Immediate post-test |
|
1998 (June) | 2000 (January) | |
1 | ACTIVE - Intervention |
|
1998 (June) | 2000 (January) | |
2 | ACTIVE - Baseline |
|
1998 (June) | 2000 (January) | |
3 | ACTIVE - Booster at 1 year |
|
1999 (May) | 2000 (December) | |
4 | ACTIVE - 1 year |
|
1999 (May) | 2001 (January) | |
5 | ACTIVE - 2 years |
|
2000 (May) | 2001 (December) | |
6 | ACTIVE - 3 years |
|
2001 (May) | 2002 (December) | |
7 | ACTIVE - Booster at 3 years |
|
2001 (May) | 2002 (December) | |
8 | ACTIVE - 5 years |
|
2003 (May) | 2004 (December) | |
9 | ACTIVE - 10 years |
|
2008 (May) | 2009 (December) |
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Health Status
-
- Exclusions: * had already experienced substantial cognitive decline * had a self-reported diagnosis of Alzheimer disease * had already experienced substantial functional decline * had medical conditions that would predispose them to imminent functional decline or death * had severe losses in vision, hearing, or communicative ability that would sufficiently impair performance to make participation impossible
- Other Criteria
- Exclusions: * younger than 65 years at screening * had recent cognitive training * were unavailable during the testing and intervention phases of the study
- Supplementary Information about selection criteria
-
The individuals in this group did not receive any intervention.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Selected sample
- Supplementary Information
-
Participants were enrolled across 6 field sites using a variety of sampling frames and recruitment strategies. Participants were recruited through state driver’s licenses and identification card registries, medical clinic rosters, senior center and community organization rosters, senior housing sites, local churches, and rosters of assistance and service programs for low-income elderly persons.
Sample Size
- Number of Participants
- 704
- Supplementary Information about selection criteria
-
Baseline and Intervention: 704 participants
Immediate post-test: 639 participants
1 year: 584 participants
2 years: 552 participants
3 years: 448 participants
5 years: 448 participants
10 years: 285 participants
Data Collection Events
# | Name | Data sources | Data sources - Biosamples | Start | End |
---|---|---|---|---|---|
0 | ACTIVE - Immediate post-test |
|
1998 (June) | 2000 (January) | |
1 | ACTIVE - Baseline |
|
1998 (June) | 2000 (January) | |
2 | ACTIVE - 1 year |
|
1999 (May) | 2001 (January) | |
3 | ACTIVE - 2 years |
|
2000 (May) | 2001 (December) | |
4 | ACTIVE - 3 years |
|
2001 (May) | 2002 (December) | |
5 | ACTIVE - 5 years |
|
2003 (May) | 2004 (December) | |
6 | ACTIVE - 10 years |
|
2008 (May) | 2009 (December) |
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Health Status
-
- Exclusions: * had already experienced substantial cognitive decline * had a self-reported diagnosis of Alzheimer disease * had already experienced substantial functional decline * had medical conditions that would predispose them to imminent functional decline or death * had severe losses in vision, hearing, or communicative ability that would sufficiently impair performance to make participation impossible
- Other Criteria
- Exclusions: * younger than 65 years at screening * had recent cognitive training * were unavailable during the testing and intervention phases of the study
- Supplementary Information about selection criteria
-
The individuals in this group received a ten-session training intervention on speed-of-processing.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Selected sample
- Supplementary Information
-
Participants were enrolled across 6 field sites using a variety of sampling frames and recruitment strategies. Participants were recruited through state driver’s licenses and identification card registries, medical clinic rosters, senior center and community organization rosters, senior housing sites, local churches, and rosters of assistance and service programs for low-income elderly persons.
Sample Size
- Number of Participants
- 712
- Supplementary Information about selection criteria
-
Baseline and Intervention: 712 participants
Immediate post-test: 653 participants
Booster: 370 participants
1 year: 601 participants
2 years: 574 participants
Booster at 3 year: 370 participants
3 years: 490 participants
5 years: 490 participants
10 years: 319 participants
Data Collection Events
# | Name | Data sources | Data sources - Biosamples | Start | End |
---|---|---|---|---|---|
0 | ACTIVE - Immediate post-test |
|
1998 (June) | 2000 (January) | |
1 | ACTIVE - Intervention |
|
1998 (June) | 2000 (January) | |
2 | ACTIVE - Baseline |
|
1998 (June) | 2000 (January) | |
3 | ACTIVE - Booster at 1 year |
|
1999 (May) | 2000 (December) | |
4 | ACTIVE - 1 year |
|
1999 (May) | 2001 (January) | |
5 | ACTIVE - 2 years |
|
2000 (May) | 2001 (December) | |
6 | ACTIVE - 3 years |
|
2001 (May) | 2002 (December) | |
7 | ACTIVE - Booster at 3 years |
|
2001 (May) | 2002 (December) | |
8 | ACTIVE - 5 years |
|
2003 (May) | 2004 (December) | |
9 | ACTIVE - 10 years |
|
2008 (May) | 2009 (December) |
Participating Studies
Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
Acronym | Name |
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Datasets
Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
Acronym | Name | Harmonization Initiatives | Individual Studies |
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