Age, Gene/Environment Susceptibility - Reykjavik Study
The objectives of the study were:
- To identify genetic and other new risk factors for selected diseases and conditions including: atherosclerosis, cognitive impairment, dementia and subtypes (i.e. Alzheimer's disease), stroke, sarcopenia, obesity, osteoporosis, diabetes, and osteoarthritis;
- To characterize phenotypes for these diseases and conditions, and study them in relation to genetic susceptibility, gene function and genetic/environmental contributions to disease;
- To identify contributory molecular markers associated with these conditions including markers of cellular maintenance and repair, markers of oxidative stress, and immunologic and endocrine indicators.
Overview
- Acronym
- AGES
- Website
- AGES
- Investigators
-
- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2002 -
- General Information on Follow Up (profile, frequency)
-
The AGES-Reykjavik examination is completed in 3 clinic visits, with a participant's full examination completed within a 4 to 6 weeks time window.
- Recruitment Target
-
- Individuals
- Number of Participants
- 5,764
- Number of Participants with Biological Samples
- 5,764
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Paper
Harris TB, Launer LJ, Eiriksdottir G, et al. Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. American journal of epidemiology, 2007; 165(9): 1076-87.
PUBMED 17351290Timeline
Population
AGES-Reykjavik stems from the Reykjavik Study, a cohort established in 1967 to prospectively study cardiovascular disease in Iceland. At the time of recruitment for the AGES-Reykjavik, participants were aged 67 years and older (born between 1907 and 1935) and living in Reykjavik.
Selection Criteria
- Minimum age
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67
- Countries
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- Iceland
- Territory
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Reykjavik
Sources of Recruitment
- Participants from Existing Studies
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- Reykjavik Study (RS)
- Supplementary Information
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Participants were randomly selected from the Reykjavik Study.
Sample Size
- Number of Participants
- 5,764
- Number of Participants with Biological Samples
- 5,764
- Supplementary Information about selection criteria
-
Baseline : 5764 participants
Follow-up:
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | AGES - Baseline |
|
|
2002 | 2006 |
| 1 | AGES - Follow-up |
|
|
2007 | 2011 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|