Overview
| Acronym |
MAAS |
|---|---|
| Website | |
| Investigators | |
| Contacts | |
| Start Year | 1992 |
| End Year | 2020 |
General Design
| Study Design | Cohort |
|---|---|
| General Information on Follow Up (profile, frequency) |
The frequency of follow-up depends on actual age, i.e. three, six, nine, twelve and 25 years for subjects aged 50 years and older, and six, nine, twelve and 25-years for younger subjects. The third follow-up (9 years) consists of a full questionnaire survey. The total duration of the follow-up program is 25 years, closing with a full questionnaire survey and the final cognitive assessment in the laboratory. |
| Recruitment Target |
|
| Number of Participants |
1,823 |
| Number of Participants with Biological Samples |
954 |
Access
| Possible Access to Data |
|
| Possible Access to Biosamples |
|
| Other |
Marker Paper
Jolles, J., van Boxtel, M. P. J., Ponds, R. W. H. M., Metsemakers, J. F. M., & Houx, P. J. (1998). De Maastricht Aging Study (MAAS): Het longitudinaal perspectief van cognitieve veroudering. Tijdschrift voor Gerontologie en Geriatrie 29(3): 120-129
Supplementary Information
Four panel studies (A1-A2-A3-A4) were executed between 1993 and 1995, sharing the same methodology with respect to sample frame, subject inclusion and stratification criteria, and basic measurement protocol. Each A-study includes an independent population sample and a set of specific variables in addition to the set of variables that is constant for all A-studies. Following this cross-sectional phase, panels were assessed in the longitudinal phase of the study.
Study Timeline
Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.
Populations
MAAS - A1
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex and levels of occupational activity (high/low).
Sources of Recruitment
| General Population |
|
|---|---|
| Supplementary Information | Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH. |
Selection Criteria
| Age | Minimum age 24, Maximum age 86 |
|---|---|
| Country | Netherlands |
| Territory | Province of Limburg |
| Other | Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants. |
Sample Size
| Number of Participants |
2,043 |
|---|---|
| Supplementary Information about Number of Participants |
Baseline Postal Survey: 2043 participants |
Data Collection Events
| Name | Description | Start | End |
|---|---|---|---|
| MAAS - A1 - Baseline Postal Survey | The postal survey collected information on... | 1992 (September) | 1992 (December) |
| MAAS - A1 - Baseline Test Program | During a home visit, the participants were... | 1993 (February) | 1993 (October) |
| MAAS - A1 - Follow-up 1 | Only participants 50 years and older were... | 1996 (July) | 1996 (December) |
| MAAS - A1 - Follow-up 2 | All initial participants were again invited to... | 1999 (June) | 1999 (December) |
| MAAS - A1 - Follow-up 3 | The postal survey collected information on... | 2002 (June) | 2002 (December) |
| MAAS - A1 - Follow-up 4 | All initial participants were again invited to... | 2005 (June) | 2005 (December) |
MAAS - A2
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Sources of Recruitment
| Specific Population |
|
|---|---|
| Supplementary Information | Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH. |
Selection Criteria
| Age | Minimum age 24, Maximum age 86 |
|---|---|
| Country | Netherlands |
| Territory | Province of Limburg |
| Other | Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants. |
Sample Size
| Number of Participants |
496 |
|---|---|
| Supplementary Information about Number of Participants |
Baseline: 496 participants |
Data Collection Events
| Name | Description | Start | End |
|---|---|---|---|
| MAAS - A2 - Baseline | Postal questionnaire and test program were... | 1994 (June) | 1994 (December) |
| MAAS - A2 - Follow-up 1 | Only participants 50 years and older were... | 1997 (June) | 1997 (December) |
| MAAS - A2 - Follow-up 2 | All initial participants were again invited to... | 2000 (June) | 2000 (December) |
| MAAS - A2 - Follow-up 3 | The postal survey collected information on... | 2003 (June) | 2003 (December) |
| MAAS - A2 - Follow-up 4 | All initial participants were again invited to... | 2006 (June) | 2006 (December) |
MAAS - A3
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Sources of Recruitment
| Specific Population |
|
|---|---|
| Supplementary Information | Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH. |
Selection Criteria
| Age | Minimum age 24, Maximum age 86 |
|---|---|
| Country | Netherlands |
| Territory | Province of Limburg |
| Other | Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants. |
Sample Size
| Number of Participants |
459 |
|---|---|
| Supplementary Information about Number of Participants |
Baseline: 459 participants |
Data Collection Events
| Name | Description | Start | End |
|---|---|---|---|
| MAAS - A3 - Baseline | Postal questionnaire and test program were... | 1994 (November) | 1995 (June) |
| MAAS - A3 - Follow-up 1 | Only participants 50 years and older were... | 1997 (November) | 1998 (May) |
| MAAS - A3 - Follow-up 2 | All initial participants were again invited to... | 2000 (November) | 2001 (May) |
| MAAS - A3 - Follow-up 3 | The postal survey collected information on... | 2003 (November) | 2004 (May) |
| MAAS - A3 - Follow-up 4 | All initial participants were again invited to... | 2006 (November) | 2007 (May) |
MAAS - A4
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Sources of Recruitment
| Specific Population |
|
|---|---|
| Supplementary Information | Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH. |
Selection Criteria
| Age | Minimum age 24, Maximum age 86 |
|---|---|
| Country | Netherlands |
| Territory | Province of Limburg. |
| Other | Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants. |
Sample Size
| Number of Participants |
436 |
|---|---|
| Supplementary Information about Number of Participants |
Baseline: 436 participants |
Data Collection Events
| Name | Description | Start | End |
|---|---|---|---|
| MAAS - A4 - Baseline | Postal questionnaire and test program were... | 1995 (May) | 1995 (November) |
| MAAS - A4 - Follow-up 1 | Only participants 50 years and older were... | 1998 (May) | 1998 (November) |
| MAAS - A4 - Follow-up 2 | All initial participants were again invited to... | 2001 (May) | 2001 (November) |
| MAAS - A4 - Follow-up 3 | The postal survey collected information on... | 2004 (May) | 2004 (November) |
| MAAS - A4 - Follow-up 4 | All initial participants were again invited to... | 2007 (May) | 2007 (November) |
Mica