Pre-Eclampsia New Emerging Team
- The objectives of this study were:
- to determine differences in physical and biochemical markers of cardiovascular risk/cardiovascular disease in women who developed pre-eclampsia, compared with those who did not, and
- to prospectively examine whether children of women with a pregnancy affected by severe pre-eclampsia, compared to children of women without a PE-affected pregnancy, have differences in neurodevelopmental performance up to 5 years of age.
Overview
- Acronym
- PE-NET
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2003 - 2010
- General Information on Follow Up (profile, frequency)
-
Participants were followed up for 5 years. Children were followed yearly until age 5 and mothers were followed up 1, 3 and 5 years postpartum.
- Recruitment Target
-
- Families
- Number of Participants
- 470
- Number of Participants with Biological Samples
- 470
- Supplementary information about number of participants
-
Mothers: 235 participants
Children: 235 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: Dr. Graeme Smith (Queen’s University)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
All data to be anonymized and encrypted. All samples to be anonymized. All conditions and restrictions are dependent on each given projects ethics board approval.
Cost
| Possible Access to Data | Not yet defined |
| Possible Access to Biosamples | Not yet defined |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Cost reductions to be considered on a case-by-case basis at the discretion of the primary investigators.
Marker Paper
Smith G.N., Walker M.C, Liu A., Wen S.W., Swansburg M., Ramshaw H., White R.R., Roddy M., Hladunewich M.; Pre-Eclampsia New Emerging Team (PE-NET).2008. A history of preeclampsia identifies women who have underlying cardiovascular risk factors.American Journal of Obstetrics & Gynecology;200(1):58.
PUBMED 18691690Timeline
Populations
PE-NET - Pre-eclampsia Mothers
The population is composed of women who were at more than 20 weeks of gestation at enrolment, diagnosed with pre-eclampsia who live within a 50km radius from the Kingston or Ottawa General Hospitals.
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- Second trimester
- Third trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Other Criteria
- Women with a history of hypertension, diabetes (including development of gestational diabetes in any pregnancy), renal disease, or cardiovascular disease and if they lived beyond a 50 km radius from either the Kingston or Ottawa General Hospitals were excluded.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
All women diagnosed with pre-eclampsia at the time of presentation to clinic or admission/transfer to either the Kingston or Ottawa General Hospitals were approached to participate.
Sample Size
- Number of Participants
- 95
- Number of Participants with Biological Samples
- 95
- Supplementary Information about selection criteria
-
Baseline: 95 participants
1 year postpartum: 66 participants
3 year postpartum: 43 participants
5 year postpartum: 17 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PE-NET - Pre-eclampsia Mothers - Baseline |
|
2003 (September) | 2009 (October) | |
| 1 | PE-NET - Pre-eclampsia Mothers - Birth |
|
|
2004 (January) | 2010 (January) |
| 2 | PE-NET - Pre-eclampsia Mothers - 1 year postpartum |
|
|
2005 (January) | 2010 (January) |
| 3 | PE-NET - Pre-eclampsia Mothers - 3 years postpartum |
|
|
2007 (January) | 2010 (January) |
| 4 | PE-NET - Pre-eclampsia Mothers - 5 years postpartum |
|
|
2009 (January) | 2010 (January) |
PE-NET - Normotensive Mothers
The population is composed of normotensive women who were at more than 20 weeks of gestation at enrolment, and who live within a 50km radius from the Kingston or Ottawa General Hospitals.
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- Second trimester
- Third trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Other Criteria
- Women with a history of hypertension, diabetes (including development of gestational diabetes in any pregnancy), renal disease, or cardiovascular disease and if they lived beyond a 50 km radius from either the Kingston or Ottawa General Hospitals were excluded.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
After each pre-eclampsia subject was recruited, the next normotensive women who matched by parity, maternal age, and race identified in the antenatal clinics or on labor and delivery were approached to participate.
Sample Size
- Number of Participants
- 140
- Number of Participants with Biological Samples
- 140
- Supplementary Information about selection criteria
-
Baseline: 140 participants
1 year postpartum: 121 participants
3 year postpartum: 62 participants
5 year postpartum: 16 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PE-NET - Normotensive Mothers - Baseline |
|
2003 (September) | 2009 (October) | |
| 1 | PE-NET - Normotensive Mothers - Birth |
|
|
2004 (January) | 2010 (January) |
| 2 | PE-NET - Normotensive Mothers - 1 year postpartum |
|
|
2005 (January) | 2010 (January) |
| 3 | PE-NET - Normotensive Mothers - 3 years postpartum |
|
|
2007 (January) | 2010 (January) |
| 4 | PE-NET - Normotensive Mothers - 5 years postpartum |
|
|
2009 (January) | 2010 (January) |
PE-NET - Pre-eclampsia Children
The population consists of the children of mothers diagnosed with pre-eclampsia while pregnant.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of participating mothers
Sample Size
- Number of Participants
- 95
- Number of Participants with Biological Samples
- 95
- Supplementary Information about selection criteria
-
Baseline: 95 participants
1 year postpartum: 66 participants
3 year postpartum: 43 participants
5 year postpartum: 17 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PE-NET - Pre-eclampsia Children - Birth |
|
2004 (January) | 2010 (January) | |
| 1 | PE-NET - Pre-eclampsia Children - 1 year postpartum |
|
|
2005 (January) | 2010 (January) |
| 2 | PE-NET - Pre-eclampsia Children - 2 year postpartum |
|
2006 (January) | 2010 (January) | |
| 3 | PE-NET - Pre-eclampsia Children - 3 year postpartum |
|
|
2007 (January) | 2010 (January) |
| 4 | PE-NET - Pre-eclampsia Children - 4 year postpartum |
|
2008 (January) | 2010 (January) | |
| 5 | PE-NET - Pre-eclampsia Children - 5 year postpartum |
|
|
2009 (January) | 2010 (January) |
PE-NET - Normotensive Children
The population consists of the children of normotensive mothers.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of participating mothers
Sample Size
- Number of Participants
- 140
- Number of Participants with Biological Samples
- 140
- Supplementary Information about selection criteria
-
Baseline: 140 participants
1 year postpartum: 121 participants
3 year postpartum: 62 participants
5 year postpartum: 16 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PE-NET - Normotensive Children - Birth |
|
2004 (January) | 2010 (January) | |
| 1 | PE-NET - Normotensive Children - 1 year postpartum |
|
|
2005 (January) | 2010 (January) |
| 2 | PE-NET - Normotensive Children - 2 year postpartum |
|
2006 (January) | 2010 (January) | |
| 3 | PE-NET - Normotensive Children - 3 year postpartum |
|
|
2007 (January) | 2010 (January) |
| 4 | PE-NET - Normotensive Children - 4 year postpartum |
|
2008 (January) | 2010 (January) | |
| 5 | PE-NET - Normotensive Children - 5 year postpartum |
|
|
2009 (January) | 2010 (January) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T15:31:48.955