Integrative Analysis of Longitudinal Studies of Aging
What is IALSA? The Integrative Analysis of Longitudinal Studies of Aging (IALSA) collaborative network was formally established in 2005 for the coordination of interdisciplinary, cross-national research aimed at the integrative understanding of within-person aging-related changes in cognitive and physical capabilities, health, personality, and well-being. It is comprised of investigators associated with over 80 longitudinal studies on aging. These population-based and longitudinal studies permit the evaluation of how factors across the lifespan determine and moderate the risk and progression of cognitive impairment and provide a basis for early detection of neurodegenerative disorders such as dementia. IALSA undertakes analysis projects which include multiple longitudinal studies to permit the evaluation of the replicability and generalizability of results across cohorts and countries. Explore the IALSA network in the Repository section of our website here.
- IALSA provides core funding for the development of different components of the Maelstrom Platform
- Maelstrom documents IALSA member studies and the variables they collect in the Maelstrom Repository. This work allows the identification of studies with comparable measures and potential for data harmonization and pooling
- IALSA provides support and scientific input for the development of the Harmonization Methods Library
Canadian Partnership for Tomorrow Project
What is CPTP? The Canadian Partnership for Tomorrow Project (CPTP) has endeavored to create the largest population cohort in Canada. CPTP is a network of five regional cohort studies — the Alberta Tomorrow Project, Atlantic PATH, the BC Generations Project, the Ontario Health Study and Quebec’s CARTaGENE — that work together in the aim of recruiting 300 000 Canadians and track them over decades. CPTP aims to build a long-term pan-Canadian data platform which researchers may use to correlate genetic, environmental, occupational, lifestyle and socio-economic factors with disease outcomes in order to identify patterns to explain some of the causes of cancer and related chronic diseases such as diabetes and heart and lung disease. Explore the CPTP network in the Repository section of our website here.
- Maelstrom is responsible for harmonizing the data collected by the five regional cohorts and compiling standard documentation on the harmonization process: harmonization decisions made, data processing algorithms, and data dictionaries for harmonized variables
- Maelstrom is developing a central web portal which will provide a single point of access for harmonized data to external researchers looking to make use of CPTP data
Promoting mental well-being and healthy ageing in cities
What is MINDMAP? The MINDMAP consortium aims to identify the opportunities offered by the urban environment for the promotion of mental wellbeing and cognitive function of older individuals in Europe. This project brings together longitudinal studies across cities in Europe, the US and Canada to explore the causal pathways and multi-level interactions between the urban environment and the social, behavioural, psychosocial and biological determinants of mental health and cognitive function in aging populations. A database of urban cohorts is being created using data harmonization and integration processes developed by Maelstrom.
- Maelstrom participates in the data harmonization activities of the MINDMAP consortium, specifically with regards to harmonizing cohort survey data
- Maelstrom also provides support in establishing an infrastructure for co-analysis of data across population registries and participating cohort studies
Cross-cohort Harmonization Project for Tomorrow
- Project timeline:
07/2015 – 03/2017
What is CHPT? The Cross-cohort Harmonization Project for Tomorrow (CHPT) aims to leverage collaborations across large population-based cohorts and to facilitate interdisciplinary, cross-national research on the determinants and etiology of cancer. The network provides tools and methods supporting data harmonization and integration between the Canadian Partnership for Tomorrow Project (CPTP) and other Canadian and international cohorts. Besides the development of a study catalogue that describes cohorts’ profile and variables collected through each wave, a number of research programs will be conducted to answer questions related to data harmonization.
Canadian Longitudinal Study on Aging
What is CLSA? The Canadian Longitudinal Study on Aging (CLSA) is a large, national, long-term study that will follow approximately 50,000 men and women between the ages of 45 and 85 for at least 20 years. The study will collect information on the changing biological, medical, psychological, social, lifestyle and economic aspects of people’s lives. These factors will be studied in order to understand how, individually and in combination, they have an impact in both maintaining health and in the development of disease and disability as people age. Explore the CLSA study in the Repository section of our website here.
- Maelstrom has customized its Onyx, Opal and Mica software to support CLSA data collection, data management, and data dissemination requirements. The Onyx software is being used in CLSA data collection centre, Opal serves as CLSA's data management platform while CLSA's data portal is powered by Mica
- Maelstrom also works with CLSA to help facilitate data harmonization (both prospective and retrospective) with other large population-based studies around the world
Public Population Project in Genomics and Society
What is P3G? The Public Population Project in Genomics and Society (P3G) is a not-for-profit consortium that provides the international research community with access to expertise, resources and innovative tools for health and social sciences research. P3G works with researchers from around the world to: (1) encourage collaboration between researchers and biobankers; (2) promote harmonization of data; (3) optimize the design, set-up and research activities of studies, biobanks, research databases and other similar health and social research infrastructures; and (4) facilitate the transfer of knowledge.
- Maelstrom Research was created as an independent research program of the Public Population Project in Genomics and Society (P3G) in 2012. The different components of the Maelstrom Platform were initially developed under the P3G consortium
Biobanking and Biomolecular Resources Research Infrastructure – Large Prospective Cohorts
What is BBMRI-LPC? Biobanking and Biomolecular Resources Research Infrastructure - Large Prospective (BBMRI-LPC) is one of the largest biobanking networks in Europe aiming to facilitate scientists’ access to large prospective study datasets on human health and disease. BBMRI-LPC aims to facilitate multinational research projects and increase the utilization of large sample collections in research on human health by improving harmonization, providing solutions for transnational access and networking.
- Under the leadership of the International Agency for research on Cancer (IARC), the BBMRI-LPC network is creating an inventory of data collected by member studies using Mica
- IARC/BBMRI-LPC also conducted a formal evaluation of Maelstrom software for data harmonization projects
a global initiative on diabetes gene-environment interaction
What is InterConnect? The overall goal of InterConnect is to establish a global network that will facilitate the co-ordination of population research on the interaction between genetic and environmental factors in the aetiology of obesity and diabetes. InterConnect aims to establish mechanisms for identification and classification of studies and the data that they hold and create a forum for harmonization of methods as a foundation for optimizing the use of existing data for the study of gene-environment interaction. This project will create the foundation for research to explain the difference in the risk of type 1 diabetes, type 2 diabetes and obesity between populations and, in particular, what explains the excess risk of diabetes in certain specific high risk populations.
- Maelstrom helps the InterConnect network document studies participating in its network through a standardized study catalogue powered by Mica
- Based on research questions identified by the consortium, Maelstrom will help InterConnect researchers harmonize data using Opal and set up a federated data infrastructure to securely co-analyze harmonized datasets across participating studies through DataSHIELD
Sino-Quebec Perinatal Initiative in Research and Information Technology
- Project timeline:
04/2014 – 03/2017
What is SPIRIT? The Sino-Quebec Perinatal Initiative in Research and Information Technology (SPIRIT) is a collaborative network for research about intra-uterine determinants of child health and development and perinatal health services in Quebec and Shanghai, China. The overall aims of this network are to harmonize pregnancy and birth cohort data for the 3D ((Découvrir, Développer, Devenir) study, the Maternal-Infant Research on Environmental Chemicals (MIREC) study and Shanghai Birth Cohort (SBC); to establish a collaborative research network on the topic of intra-uterine determinants of child health and development and on perinatal health services in Quebec and Shanghai (China); to establish an infrastructure of knowledge transfer and application between the partners and users of the network leading to updated guidelines, health policies and knowledge transfer activities in clinical practice; and to reinforce the strategic positioning of academic and industrial partners in Quebec, China and internationally for providing access to new markets and expertise. Explore the SPIRIT network in the Repository section of our website here.
- Maelstrom provides support to SPIRIT through development of a standardized study catalogue using the Mica software and through the implementation of a harmonization and federated data analysis platform using Opal and DataSHIELD
Canadian Data Integration Centre
What is CDIC? The Canadian Data Integration Centre is a strategic partnership between CARTaGENE, Maelstrom Research, and the Ontario Institute for Cancer Research. CDIC provides bioinformatics support to genomic researchers by providing the software and analytic systems to collect and harmonize data, analyze it and electronically publish the results. Among its services, CDIC assists in the design, collection and analysis of human genomic, clinical and phenomic data, harmonization of data from multiple sources, and development of integrative data portals to permit researchers and other clients to effectively mine the data. It works with other large-scale projects, delivering client-oriented data transfer services that are customizable to researchers’ needs.
- CDIC permits to develop Maelstrom Research tools to better support harmonization and co-analysis of genomic data.
- Maelstrom Research provides data harmonization and integration services to CDIC clients.
What are External Users? Additional studies, projects or organizations are currently using, or have used, software developed by our team to support their activities.
Individual studies using software to collect, manage, or disseminate information about data and samples collected:
- IMPPC (Institute de Medicina Predictiva i Personalitzada del Cancer) Biobank (Spain).
- Cartagene (Canada).
Organizations using software to manage or harmonize data:
- Ontario Brain Institue (Canada)
- Ontario Institute for Cancer Research (Canada)
- NeuroDevNet (Canada)
Organizations using software to offer data management, harmonization or dissemination services:
- Biskit (United Kingdom)
- The hyve (The Netherlands)
- WESTAT (United States)