The general aim of the study is to assess a wide range of modifiable lifestyle factors (diet, dietary supplements, physical activity, smoking, alcohol, body weight and other anthropometric measures, etc.) and genetic factors in a large population-based longitudinal cohort of Swedish middle-aged and elderly men.

  • Extensive questionnaire-based data on diet and other lifestyle factors enables studies of relevance for primary and secondary prevention of cancer (common and rare types), cardiovascular diseases, type 2 diabetes, osteoporosis, neurodegenerative diseases, age-related cataract, rheumatoid arthritis, lower urinary tract symptoms, chronic obstructive pulmonary disease, obesity etc.
  • Extensive register-based information on health status facilitates studies of multimorbidity, polypharmacy, ageing, and overall and cause-specific mortality.
  • Biorepository with a broad spectrum of samples (saliva, blood, urine, adipose tissue, faeces), complemented with clinical data, enables studies of genetic factors and other factors of relevance for detection of biomarkers for early diagnosis and progression.

Study Design

Study Design Cohort
General Information on Follow Up (profile, frequency)

After the baseline, the participants were followed-up twice for updated exposure information, in 2008 and 2009.
Information on health status is updated every year by linkage to registries.

Recruitment Target
  • Individuals
Number of Participants

48,850

Number of Participants with Biosamples

32,194

Supplementary Information about Number of Participants

Saliva sample: 31 162 participants
Clinical subcohort samples: ~3,500 (June 2016; ongoing)

Access

Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)

Biosamples

Marker Paper

Harris H, Håkansson N, Olofsson C, Stackelberg O, Julin B, Åkesson A, et al. The Swedish mammography cohort and the cohort of Swedish men: study design and characteristics of two population-based longitudinal cohorts. OA Epidemiology 2013 Oct 01;1(2):16.

Study Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.

Population

COSM population

The cohort is composed of men born between 1918 and 1952 and residing in Central Sweden (Västmanland and Örebro Counties) at the time of recruitment.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information All men born between 1918 and 1952 were invited to participate.

Selection Criteria

Gender Men only
Age Minimum age 45, Maximum age 79
Country Sweden
Territory Västmanland and Örebro Counties (central Sweden)

Sample Size

Number of Participants

48,850

Number of Participants with Biosamples

32,194

Supplementary Information about Number of Participants

1997: 48 850 participants
2008: 29 503 participants
2009: 26 156 participants
Saliva sample: 31 162 participants
Clinical subcohort samples: ~3,500 (June 2016; ongoing)

Data Collection Events

NameDescriptionStartEnd
COSM - 1997 (baseline)

The questionnaire was self-administered and...

1997 (September)1997 (December)
COSM - Registries

Information from health registries is updated...

1997 (September)2016 (December)
COSM - Saliva

Saliva was collected at different time points...

2005 (January)2008 (December)
COSM - 2008 (2nd (a) follow-up)

The 2008 questionnaire collected information...

2008 (September)2008 (December)
COSM - 2009 (2nd (b) follow-up)

The third questionnaire collected information...

2009 (April)2009 (December)
COSM - Clinical examination

Participants from Västerås were invited to...

2010 (April)2016 (December)
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Variable Classification