Study on Nutrition and Cardiovascular Risk in Spain

ENRICA is a multipurpose cohort aiming to examine the associations between lifestyle and healthy aging in older adults. Among lifestyle risk factors, the focus is on diet, physical activity, sedentary behavior, and alcohol drinking patterns. As regards to the outcome variables, the main focus is health-related quality of life, the frailty syndrome and physical functioning.

Overview

Acronym
Seniors-ENRICA
Website
Seniors-ENRICA
Investigators
Dr. Adrián Carballo Casla
Aging Research Center, Karolinska Institutet
Dr. Mercedes Sotos Prieto
Universidad Autónoma de Madrid
Dr. Rosario Ortolá
Universidad Autónoma de Madrid
Prof. Fernando Rodríguez Artalejo
Universidad Autonoma de Madrid
Dr. José R. Banegas
Universidad Autónoma de Madrid
Dr. Graciani Pérez-Regadera
Universidad Autónoma de Madrid
Dr. Esther Garcia-Esquinas
National Center for Epidemiology, Instituto de Salud Carlos III
Contacts
Dr. Rosario Ortolá
Universidad Autónoma de Madrid
Dr. Mercedes Sotos Prieto
Universidad Autónoma de Madrid
Prof. Fernando Rodríguez Artalejo
Universidad Autonoma de Madrid

General Design

Study design
Cohort
Start - End Year
2008 - 2022
General Information on Follow Up (profile, frequency)
Partipants were recruited between 2008 and 2010. They were then followed-up in 2012, 2015 and 2017 for the first phase (Seniors-ENRICA-1). The second phase (Seniors-ENRICA-2) participants were recruited between 2015 and 2017, and were then followed-up in 2019 and between 2022 and 2023.
Recruitment Target
  • Individuals
Number of Participants
5,890
Number of Participants with Biological Samples
5,890
Supplementary information about number of participants
Seniors-ENRICA-1 : 2614 participants Seniors-ENRICA-2 : 3276 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Marker Papers

Rodríguez-Artalejo F, Graciani A, Guallar-Castillón P, et al. Justificación y métodos del estudio sobre nutrición y riesgo cardiovascular en España (ENRICA) [Rationale and methods of the study on nutrition and cardiovascular risk in Spain (ENRICA)]. Rev Esp Cardiol. 2011 Oct;64(10):876-82. Spanish. doi: 10.1016/j.recesp.2011.05.019. Epub 2011 Aug 6.

PUBMED 21821340

León-Muñoz LM, García-Esquinas E, López-García E, et al. Major dietary patterns and risk of frailty in older adults: a prospective cohort study. BMC Med. 2015 Jan 20;13:11. doi: 10.1186/s12916-014-0255-6.

PUBMED 25601152

Sánchez-Sánchez JL, Ortolá R, Banegas JR, Lucia A, et al. Association between physical activity and sedentary behaviour and changes in intrinsic capacity in Spanish older adults (Seniors-ENRICA-2): a prospective population-based study. Lancet Healthy Longev. 2025 May;6(5):100681. doi: 10.1016/j.lanhl.2024.100681. Epub 2025 May 22.

PUBMED 40414228

Maroto-Rodriguez J, Delgado-Velandia M, Ortolá R, García-Esquinas E, Martinez-Gomez D, Struijk EA, Lopez-Garcia E, Rodríguez-Artalejo F, Sotos-Prieto M. A Mediterranean Lifestyle and Frailty Incidence in Older Adults: The Seniors-ENRICA-1 Cohort. J Gerontol A Biol Sci Med Sci. 2022 Sep 1;77(9):1845-1852. doi: 10.1093/gerona/glab292. PMID: 34614144.

PUBMED 34614144

Timeline

Populations

Seniors-ENRICA-1
The population is composed of non-institutionalized individuals aged 60 years and older and living across Spain.

Selection Criteria

Minimum age
60
Countries
  • Spain
Ethnic Origin
  • Caucasian
Other Criteria
Inclusion criteria: ENRICA-2: * Participants must be aged 65 to 94 years and living in the city of Madrid (Spain) or in four surrounding large towns (Getafe, Torrejón de Ardoz, Alcorcón, and Alcalá de Henares).

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Participants were selected by stratified cluster sampling of the non-institutionalized adult population of Spain. The sample was first stratified by province and municipality size. Clusters were then randomly selected in two stages: municipalities and census sections. Finally, households within each section were selected by random telephone dialing. Individuals within households were selected proportionally to the age and sex distribution of the Spanish population.

Sample Size

Number of Participants
2,614

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Senior-ENRICA-1 - Baseline
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
  • Urine
2008 (October) 2010 (June)
1 Senior-ENRICA-1 - Follow-up 1
  • Questionnaires
  • Physical measures
2012 (March) 2012 (December)
2 Senior-ENRICA-1 - Follow-up 2
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
2015 (January) 2015 (June)
3 Seniors-ENRICA-1 - Follow-up 3
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
2017 2017
Seniors-ENRICA-2

The population is composed of non-institutionalized individuals aged 65 years and older and living in the city of Madrid, Spain, or in four surrounding large towns: Getafe, Torrejón de Ardoz, Alcorcón, and Alcalá de Henares.

Selection Criteria

Minimum age
65
Countries
  • Spain
Territory
Madrid, Spain, or in four surrounding large towns: Getafe, Torrejón de Ardoz, Alcorcón, and Alcalá de Henares.

Sources of Recruitment

General Population
  • Selected sample
  • Random digit dialing
Supplementary Information
Participants were recruited through sex-stratified and district-stratified random sampling of all individuals holding a national health-care card.

Sample Size

Number of Participants
3,276

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Seniors-ENRICA-2 - Baseline
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
2015 (December) 2017 (November)
1 Seniors-ENRICA-2 - Follow-up 1
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
2018 (September) 2019 (November)
2 Seniors-ENRICA-2 - Follow-up 2
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
2021 (November) 2023 (March)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2026-06-26T23:26:56.401