The main objective of GCAT is to integrate and to assess the role of genomic, epigenomic, environmental and lifestyle factors in the development of major chronic diseases (e.g. cancer, cardiovascular, respiratory, autoimmune, neurological or metabolic diseases) in Catalonia, Spain. Furthermore, GCAT aimed to assess the prevalence of epidemiological and genetic risk factors associated with the incidence of chronic diseases.

Study Design

Study Design Cohort
General Information on Follow Up (profile, frequency)

The active first follow-up through web-based questionnaire began in March 2018 and ended in December 2018. Electronic Health Register linking participants from Public Health Care System begins in January 2019 and will then be followed annually.

Recruitment Target
  • Individuals
Number of Participants

19,386

Number of Participants with Biosamples

19,386

Access

Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)

Biosamples

Marker Paper

Obón-Santacana M, Vilardell M, Carreras A, et al. GCAT|Genomes for life: a prospective cohort study of the genomes of Catalonia. BMJ Open 2018 Mar 27;8:e018324.

PUBMED 29593016

Supplementary Information

Galván-Femenía I, Obón-Santacana M, Piñeyro D, Guindo-Martinez M, Duran X, Carreras A, Pluvinet R, Velasco J, Ramos L, Aussó S, Mercader JM, Puig L, Perucho M, Torrents D, Moreno V, Sumoy L, de Cid R. Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort. Journal of Medical Genetics 2018;55:765-77. PMID 30166351

Study Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.

Populations

GCAT Population

The population is composed of residents of Catalonia, Spain, aged 40 to 65 years old. Participants should not have mental or health impairment disorders and should not be planning to leave Catalonia within the 5 years post-recruitment.

Sources of Recruitment

General Population
  • Volunteer enrolment
  • Selected sample
Supplementary Information Participants are mostly enrolled from blood donors invited through the Blood and Tissue Bank (BST), a public agency of the Catalan department of Health. The recruitment procedures include phone call, mail, GCAT web site or in person. Participants have to present themselves at a recruitment centre (11 permanent + additional temporary centres across Catalonia).

Selection Criteria

Age Minimum age 40, Maximum age 65
Country Spain
Territory Catalonia
Health Status Participants should not have mental or health impairment disorders that impede giving written informed consent or efficient communication.
Other Participants should be able to understand at least one of the two official languages (Catalan or Spanish), possess an Individual Health System Identification Card, and be current residents of Catalonia.
Supplementary Information Participants that plan to leave Catalonia within the next 5 years after recruitment are excluded.

Sample Size

Number of Participants

19,386

Number of Participants with Biosamples

19,386

Data Collection Events

NameDescriptionStartEnd
GCAT - Baseline

Participants completed electronic computer...

2014 (March)2018 (March)
GCAT - Active Follow-Up 1

All enrolled participants were characterized by...

2018 (March)2018 (December)
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Variable Classification