Women’s Genome Health Study
The primary aim of the WGHS is to create a comprehensive, fully searchable genome-wide database of more than 360 000 single nucleotide polymorphisms among at least 25 000 initially healthy American women participating in the ongoing Women's Health Study.
Investigations within the WGHS seek to identify relevant patterns of genetic polymorphism that relate to multiple intermediate phenotypes and will also allow exploration of gene-environment and gene-gene interactions as they relate to incident disease states.
Overview
- Acronym
- WGHS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2006 -
- General Information on Follow Up (profile, frequency)
-
Ongoing DNA analyses from the participants' blood sample provided at baseline (1992-1995) of the WHS study.
- Recruitment Target
-
- Individuals
- Number of Participants
- 28,345
- Number of Participants with Biological Samples
- 28,345
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Ridker PM, Chasman DI, Zee RY, Parker A, et al. Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women. Clinical Chemistry, 2008; 54(2): 249-55.
PUBMED 18070814Timeline
Population
The cohort is composed of participants of the WHS study. The WHS included initially healthy American women, aged 45 years and older, with no previous history of cardiovascular disease, cancer or other major chronic illnesses at baseline in 1992-1995.
Selection Criteria
- Sex
-
Women only
- Minimum age
-
45
- Countries
-
- United States of America
Sources of Recruitment
- Participants from Existing Studies
-
- Women's Health Study
- Supplementary Information
-
All members of the WGHS cohort were participants in the WHS who provided an adequate baseline blood sample for plasma and DNA analysis and who gave consent for blood-based analyses and long-term follow-up.
Sample Size
- Number of Participants
- 28,345
- Number of Participants with Biological Samples
- 28,345
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | WGHS analyses |
|
|
2006 (October) | 2014 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|