Switzerland can rely on a number of high quality prospective cohort studies ranging from population-based to nation-wide patient-based studies, some of which span decades. Following the increasing demand for the implementation of collaborative environments, the Swiss Personalized Health Network (SPHN) developed a harmonized cohort strategy to bring Swiss cohorts forward on both the national and international level. The strategy promotes the enhancement of findability and accessibility of national cohorts, improving research quality and fostering the establishment of international collaborations. SPHN is a national data infrastructure under the responsibility of the Swiss Academy of Medical Sciences (SAMS) in collaboration with the SIB Swiss Institute of Bioinformatics. SPHN makes health data interoperable and shareable for research in Switzerland.