3D Study - Design, Develop, Discover

The main objective of the 3D study is to create a large pregnancy and birth cohort, allowing for the assessment of the effects of combined prenatal exposure on both birth outcomes and longer-term infant and child health. The specific objectives are to: * Determine the effects of pre- and post-natal exposures to environmental contaminants, nutritional factors and psychosocial stress on pregnancy and neurodevelopmental outcomes; * Assess the contribution of social, genetic, epigenetic, nutritional and environmental factors to the etiology and outcomes of IUGR and preterm birth; * Assess the effects of assisted reproductive technologies (ART) on indicators of epigenetic modifications, and the relationship between such epigenetic changes and child neurodevelopmental, cardiovascular, and metabolic outcomes; and * Understand the mechanisms linking children's early development with mental health after the transition to formal school by examining the challenges and available resources during the transition from preschool to school, and evaluating the child’s adjustment to school and his/her new environment (3D-Transition study) .

Overview

Acronym
3D
Website
3D
Investigators
Dr. Nadia Abdelouahab
University Hospital Center of Sherbrooke
Dr. Lise Dubois
University of Ottawa
Dr. Zhong Cheng Luo
Université de Montréal
Dr. Jacques Michaud
Université de Montréal
Dr. Jean-Marie Moutquin
University of Sherbrooke
Dr. Gina Muckle
Université Laval
Dr. Jean Séguin
Université de Montréal
Dr. Margaret Somerville
University of Notre Dame Australia
Dr. Jacquetta Trasler
McGill University
Dr. Richard E. Tremblay
Université de Montréal
Dr. François Audibert
Université de Montréal
Dr. Natalie Castellanos-Ryan
Université de Montréal
Dr. Sophie Parent
Université de Montréal
Dr. Isabelle Archambault
Université de Montréal
Dr. Michel Boivin
Université Laval
Dr. Catherine Herba
Université du Québec à Montréal
Dr. Sonia Lupien
Université de Montréal
Contacts
Corinne Mavungu-Blouin
Centre de recherche Azrieli du CHU Sainte-Justine

General Design

Study design
Cohort
Start - End Year
2010 -
General Information on Follow Up (profile, frequency)
Pregnant women and their partners were recruited during the first trimester of pregnancy (8–14 weeks) and followed up at mid (20–24 weeks) and late (32–35 weeks) pregnancy, and at delivery. Postnatal visits took place at 3 months, 1 year, and 2 years following the birth. From age 4 years onward, both parents and children were followed at 4, 5, 6, 7, 8, 9 and 10 years after birth (3D-Transition Study). Starting in 2023, parents and adolescents (cohort 1 aged 12 years, cohort 2 aged 11 years, and cohort 3 aged 10 years in 2023) are being followed annually until 2029 (3D-Transition ADO follow-up).
Recruitment Target
  • Families
Number of Participants
8,365
Number of Participants with Biological Samples
5,700
Supplementary information about number of participants
Mothers: 2456 participants
Children: 2456 participants
Partners: 2333 participants
Teachers: 1120 participants (623 children have at least one questionnaire completed by a teacher) 3D-Transition study:
Mothers: 939 participants
Partners: 489 participants
Teachers: 606 participants ADO follow-up study:
Parents (mother or father): 714 participants
Children: 571 participants
Supplementary Information

ClinicalTrials registration of both initial and follow-up protocols (respectively):

Clinical trial Initial

Clinical trial Follow-up

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Sector of research

Possible Access to Data Possible Access to Biosamples
Investigators from the public sector
Investigators from the private sector
Investigators from not-for-profit organization

The Ancillary Study Committee of the Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO)

Transfer

Possible Access to Data Possible Access to Biosamples
Can leave the study facility
Can leave the country

Codification, encryption

Cost

Possible Access to Data Variable Cost
Possible Access to Biosamples Variable Cost

Cost reduction for co-analyses

Possible Access to Data
Possible Access to Biosamples

Case by case

Marker Papers

William DF, Shapiro GD, Audibert F, Dubois L, et al. 3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario. Paediatric and Perinatal Epidemiology, 2016;30(6):623-632.

PUBMED 27781295

Rioux C, Parent S, Castellanos-Ryan N, Archambault I, et al. The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design. American Journal of Epidemiology, 2021;190(11):2262-2274.

PUBMED 33987638

Parent S, Lupien S, Herba CM, Dupéré V, et al. Children’s cortisol response to the transition from preschool to formal schooling: A review. Psychoneuroendocrinology, 2019;99:196-205.

PUBMED 30253327

Timeline

Populations

3D - Children
The population is composed of the children of mothers recruited for the 3D study.

Selection Criteria

Newborns
Countries
  • Canada
Canadian Provinces
  • Quebec

Sources of Recruitment

Specific Population
  • Other specific population : Newborn children of the women enrolled in the study

Sample Size

Number of Participants
2,456
Number of Participants with Biological Samples
1,010
Supplementary information about number of participants
3D-Transition study: 939 participants 3D-Transition-Ado follow up: 608 participants

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 3D - Children - Delivery and immediate postpartum
  • Biosamples
  • Other : Medical records
  • Hair
  • Cord blood
  • Tissues : Placenta
  • Other :

    Meconium and umbilical cord

2010 (November) 2013 (March)
1 3D - Children - 3 months postpartum
  • Questionnaires
  • Physical measures
2011 (March) 2013 (July)
2 3D - Children - 12 months postpartum
  • Questionnaires
  • Cognitive measures
  • Physical measures
2011 (December) 2014 (March)
3 3D - Children - 24 months postpartum
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
2013 (March) 2015 (March)
4 3D - Children - Spring prekindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Saliva
2017 (March) 2018 (August)
5 3D - Children - Spring kindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Saliva
2017 (March) 2019 (August)
6 3D - Children - Fall kindergarten
  • Questionnaires
  • Biosamples
  • Saliva
2017 (September) 2018 (December)
7 3D - Children - Fall grade 1
  • Questionnaires
  • Biosamples
  • Saliva
2017 (September) 2019 (December)
8 3D - Children - Spring grade 1
  • Questionnaires
  • Cognitive measures
  • Physical measures
2018 (March) 2020 (August)
9 3D - Children - Spring grade 2
  • Questionnaires
2019 (March) 2021 (August)
10 3D - Children - Spring grade 3
  • Questionnaires
2020 (March) 2021 (August)
11 3D - Children - Spring grade 4
  • Questionnaires
2021 (March) 2021 (August)
12 3D - Children - Spring grade 5
  • Questionnaires
2022 (March) 2022 (August)
13 3D - Children - C1 ADO follow-up 1
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2023 2023
14 3D - Children - C2 ADO follow-up 1
  • Questionnaires
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2023 2023
15 3D - Children - C3 ADO follow-up 1
  • Questionnaires
  • Biosamples
  • Other : Home observation
  • Hair
2023 2023
16 3D - Children - C1 ADO follow-up 2
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2024 2024
17 3D - Children - C2 ADO follow-up 2
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2024 2024
18 3D - Children - C3 ADO follow-up 2
  • Questionnaires
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2024 2024
19 3D - Children - C1 ADO follow-up 3
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2025 2025
20 3D - Children - C2 ADO follow-up 3
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2025 2025
21 3D - Children - C3 ADO follow-up 3
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2025 2025
22 3D - Children - C1 ADO follow-up 4
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2026 2026
23 3D - Children - C2 ADO follow-up 4
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2026 2026
24 3D - Children - C3 ADO follow-up 4
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School results
  • Hair
2026 2026
25 3D - Children - C1 ADO follow-up 5
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2027 2027
26 3D - Children - C2 ADO follow-up 5
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2027 2027
27 3D - Children - C3 ADO follow-up 5
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2027 2027
28 3D - Children - C1 ADO follow-up 6
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation, School records
  • Hair
2028 2028
29 3D - Children - C2 ADO follow-up 6
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2028 2028
30 3D - Children - C3 ADO follow-up 6
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2028 2028
31 3D - Children - C3 ADO follow-up 7
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Other : Home observation
  • Hair
2029 2029
3D - Mothers
The population is composed of 8 to 14 weeks pregnant women from the general population between 18 and 47 years of age, who are fluent in French or English, who were attending prenatal clinics (ultrasound, midwife and/or doctor’s clinics) during the first trimester of pregnancy and who plan to deliver in a study hospital.

Selection Criteria

Sex
Women only
Minimum age
18
Maximum age
47
Pregnant Women
  • First trimester
Countries
  • Canada
Canadian Provinces
  • Quebec
Other Criteria
Exclusion criteria: Multiple pregnancies, intention to donate or bank cord blood, intravenous drug users, or if the woman has any one or more of the following conditions: HIV+ status, renal disease with altered renal function, any collagen vascular disease requiring active treatment (e.g. lupus, scleroderma), epilepsy, cardiovascular disease, serious pulmonary disease, cancer, or severe hematologic disorder.

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Women were recruited between May 25, 2010 and August 30, 2012 at one of nine study centres during routine first-trimester prenatal visits to study hospitals and infertility clinics.

Sample Size

Number of Participants
2,456
Number of Participants with Biological Samples
2,357
Supplementary information about number of participants
3D-Transition study: 939 participants

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 3D - Mothers - Prenatal visit 1 (8 to 14 weeks)
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Urine
  • Other : Vaginal secretions
2010 (June) 2012 (September)
1 3D - Mothers - Prenatal visit 2 (20 to 24 weeks)
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Urine
  • Other : Vaginal secretions
2010 (August) 2012 (November)
2 3D - Mothers - Prenatal visit 3 (32 to 35 weeks)
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Urine
  • Nail
2010 (October) 2013 (February)
3 3D - Mothers - Delivery and immediate postpartum
  • Questionnaires
  • Biosamples
  • Other : Medical records
  • Blood
  • Hair
  • Tissues : Placenta
2010 (November) 2013 (March)
4 3D - Mothers - 3 months postpartum
  • Questionnaires
2011 (March) 2013 (July)
5 3D - Mothers - 12 months postpartum
  • Questionnaires
2011 (December) 2014 (March)
6 3D - Mothers - 24 months postpartum
  • Questionnaires
2013 (March) 2015 (March)
7 3D - Mothers - Spring prekindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
2017 (March) 2018 (August)
8 3D - Mothers - Spring kindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
2017 (March) 2019 (August)
9 3D - Mothers - Fall kindergarten
  • Questionnaires
2017 (September) 2018 (December)
10 3D - Mothers - Fall grade 1
  • Questionnaires
2017 (September) 2019 (December)
11 3D - Mothers - Spring grade 1
  • Questionnaires
  • Cognitive measures
  • Physical measures
2018 (March) 2020 (August)
12 3D - Mothers - Spring grade 2
  • Questionnaires
2019 (March) 2021 (August)
13 3D - Mothers - Spring grade 3
  • Questionnaires
2020 (March) 2021 (August)
14 3D - Mothers - Spring grade 4
  • Questionnaires
2021 (March) 2021 (August)
15 3D - Mothers - Spring grade 5
  • Questionnaires
2022 (March) 2022 (August)
16 3D - Mothers - C1 ADO follow-up 1
  • Questionnaires
2023 2023
17 3D - Mothers - C2 ADO follow-up 1
  • Questionnaires
2023 2023
18 3D - Mothers - C3 ADO follow-up 1
  • Questionnaires
2023 2023
19 3D - Mothers - C1 ADO follow-up 2
  • Questionnaires
2024 2024
20 3D - Mothers - C2 ADO follow-up 2
  • Questionnaires
2024 2024
21 3D - Mothers - C3 ADO follow-up 2
  • Questionnaires
2024 2024
22 3D - Mothers - C1 ADO follow-up 3
  • Questionnaires
2025 2025
23 3D - Mothers - C2 ADO follow-up 3
  • Questionnaires
2025 2025
24 3D - Mothers - C3 ADO follow-up 3
  • Questionnaires
2025 2025
25 3D - Mothers - C1 ADO follow-up 4
  • Questionnaires
2026 2026
26 3D - Mothers - C2 ADO follow-up 4
  • Questionnaires
2026 2026
27 3D - Mothers - C3 ADO follow-up 4
  • Questionnaires
2026 2026
28 3D - Mothers - C1 ADO follow-up 5
  • Questionnaires
2027 2027
29 3D - Mothers - C2 ADO follow-up 5
  • Questionnaires
2027 2027
30 3D - Mothers - C3 ADO follow-up 5
  • Questionnaires
2027 2027
31 3D - Mothers - C1 ADO follow-up 6
  • Questionnaires
2028 2028
32 3D - Mothers - C2 ADO follow-up 6
  • Questionnaires
2028 2028
33 3D - Mothers - C3 ADO follow-up 6
  • Questionnaires
2028 2028
3D - Partners
The population is composed of the partners of the mothers recruited for the 3D study.

Selection Criteria

Countries
  • Canada
Canadian Provinces
  • Quebec

Sources of Recruitment

Specific Population
  • Other specific population : Partners of the mothers recruited
Supplementary Information
Women and their partners were recruited between May 25, 2010 and August 30, 2012 at one of nine study centres during routine first-trimester prenatal visits to study hospitals and infertility clinics.

Sample Size

Number of Participants
2,333
Number of Participants with Biological Samples
2,333
Supplementary information about number of participants
3D-Transition study: 939 participants

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 3D - Partners - Prenatal visit 1 (8 to 14 weeks)
  • Questionnaires
  • Biosamples
  • Blood
  • Urine
2010 (June) 2012 (September)
1 3D - Partners - 3 months postpartum
  • Questionnaires
2011 (March) 2013 (July)
2 3D - Partners - 12 months postpartum
  • Questionnaires
2011 (December) 2014 (March)
3 3D - Partners - 24 months postpartum
  • Questionnaires
2013 (March) 2015 (March)
4 3D - Partners - Spring prekindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
2017 (March) 2018 (August)
5 3D - Partners - Spring kindergarten
  • Questionnaires
  • Cognitive measures
  • Physical measures
2017 (March) 2019 (August)
6 3D - Partners - Fall kindergarten
  • Questionnaires
2017 (September) 2018 (December)
7 3D - Partners - Fall grade 1
  • Questionnaires
2017 (September) 2019 (December)
8 3D - Partners - Spring grade 1
  • Questionnaires
  • Cognitive measures
  • Physical measures
2018 (March) 2020 (August)
9 3D - Partners - Spring grade 2
  • Questionnaires
2019 (March) 2021 (August)
10 3D - Partners - Spring grade 3
  • Questionnaires
2020 (March) 2021 (August)
11 3D - Partners - Spring grade 4
  • Questionnaires
2021 (March) 2021 (August)
12 3D - Partners - Spring grade 5
  • Questionnaires
2022 (March) 2022 (August)
13 3D - Partners - C1 ADO follow-up 1
  • Questionnaires
2023 2023
14 3D - Partners - C2 ADO follow-up 1
  • Questionnaires
2023 2023
15 3D - Partners - C3 ADO follow-up 1
  • Questionnaires
2023 2023
16 3D - Partners - C1 ADO follow-up 2
  • Questionnaires
2024 2024
17 3D - Partners - C2 ADO follow-up 2
  • Questionnaires
2024 2024
18 3D - Partners - C3 ADO follow-up 2
  • Questionnaires
2024 2024
19 3D - Partners - C1 ADO follow-up 3
  • Questionnaires
2025 2025
20 3D - Partners - C2 ADO follow-up 3
  • Questionnaires
2025 2025
21 3D - Partners - C3 ADO follow-up 3
  • Questionnaires
2025 2025
22 3D - Partners - C1 ADO follow-up 4
  • Questionnaires
2026 2026
23 3D - Partners - C2 ADO follow-up 4
  • Questionnaires
2026 2026
24 3D - Partners - C3 ADO follow-up 4
  • Questionnaires
2026 2026
25 3D - Partners - C1 ADO follow-up 5
  • Questionnaires
2027 2027
26 3D - Partners - C2 ADO follow-up 5
  • Questionnaires
2027 2027
27 3D - Partners - C3 ADO follow-up 5
  • Questionnaires
2027 2027
28 3D - Partners - C1 ADO follow-up 6
  • Questionnaires
2028 2028
29 3D - Partners - C2 ADO follow-up 6
  • Questionnaires
2028 2028
30 3D - Partners - C3 ADO follow-up 6
  • Questionnaires
2028 2028
3D - Teachers
The population is composed of the main teachers of the children recruited for the 3D study.

Selection Criteria

Countries
  • Canada
Canadian Provinces
  • Quebec
Other Criteria
Occupation as teachers

Sources of Recruitment

Specific Population
  • Members of an association

Sample Size

Number of Participants
1,120
Supplementary information about number of participants
623 children have at least one questionnaire completed by a teacher

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 3D - Teachers - Spring prekindergarten
  • Questionnaires
2017 (March) 2018 (August)
1 3D - Teachers - Spring kindergarten
  • Questionnaires
2017 (March) 2019 (August)
2 3D - Teachers - Fall kindergarten
  • Questionnaires
2017 (September) 2018 (December)
3 3D - Teachers - Fall grade 1
  • Questionnaires
2017 (September) 2019 (December)
4 3D - Teachers - Spring grade 1
  • Questionnaires
2018 (March) 2020 (August)
5 3D - Teachers - Spring grade 2
  • Questionnaires
2019 (March) 2021 (August)
6 3D - Teachers - Spring grade 3
  • Questionnaires
2020 (March) 2021 (August)
7 3D - Teachers - Spring grade 4
  • Questionnaires
2021 (March) 2021 (August)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2026-01-26T11:40:35.708