50-year-olds in Gothenburg

The objective of the study has been to investigate coronary risk factors and development of coronary heart disease in a group of Swedish urban men of the same age: 50 years. Also, to investigate the risk of cardiovascular diseases among 50-year-old women.

Overview

Acronym
50YMG
Website
50YMG
Investigators
Prof. Per-Olof Hansson
University of Gothenburg
Prof. Kurt Svärdsudd
Uppsala University
Prof. Annika Rosengren
University of Gothenburg
Prof. Lennart Welin
Contacts
Prof. Per-Olof Hansson
University of Gothenburg
Prof. Kurt Svärdsudd
Uppsala University

General Design

Study design
Cohort
Start - End Year
1963 - 2013
General Information on Follow Up (profile, frequency)
Participants born in 1913 participated in the survey when they were 50 years old and were followed up when they were 54, 60, 67, 75 and 80 years old.

All participants were followed up until death or until December 31, 2011.
Recruitment Target
  • Individuals
  • Families
Number of Participants
4,503
Number of Participants with Biological Samples
4,503
Supplementary information about number of participants
Since 1963, the study has been filled with new 50-year-olds, and since 2003 women are also included in the study. New samples of 50-year-old men were drawn in 1973, 1983, 1993-1994, 2003-2004 and 2013-2014.

  • Men born in 1913, 855 participants.
  • Men born in 1923, 226 participants.
  • Men born in 1933, 776 participants.
  • Men born in 1943, 798 participants.
  • Men born in 1953, 595 participants.
  • Men born in 1963, 313 participants.
  • Women born in 1953, 677 participants.
  • Sons to men born in 1913, 263 participants.
  • Access

    Availability of data and biosamples

    Possible Access to Data
    Possible Access to Biosamples
    Other

    Marker Papers

    Zhong Y, Rosengren A, Fu M, et al. Secular changes in cardiovascular risk factors in Swedish 50-year-old men over a 50-year period: The study of men born in 1913, 1923, 1933, 1943, 1953 and 1963. EUR J PREV CARDIOL. 2017 APR;24(6):612-620.

    PUBMED 27794107

    Tibbling G, Aurell E, Hjortzberg-Nordlund H et al. A General Health-examination of a random sample of 50-year-old men in Goteborg. Acta Med Scand. 1965 Jun;177:739-49.

    PUBMED 14334667

    Welin L, Svärdsudd K, Wilhelmsen L et al. Analysis of risk factors for stroke in a cohort of men born in 1913. The New England Journal of Medicine. 1987 Aug;317(9):521-526.

    PUBMED 3614303

    Wilhelmsen L, Svärdsudd K, Korsan-Bengtsen K, et al. Fibrinogen as a risk factor for stroke and myocardial infarction. The New England Journal of Medicine. 1984 Aug;311(8):501-505.

    PUBMED 6749207

    Hansson PO, Welin L, Tibblin G et al. Deep vein thrombosis and pulmonary embolism in the general population. 'The Study of Men Born in 1913'. Arch Intern Med. 1997 Aug 11-25;157(15):1665-70.

    PUBMED 9250227

    Supplementary Information

    Additional paper(s)
    Wilhelmsen L, Svärdsudd K, Eriksson H, et al. Factors associated with reaching 90 years of age: a study of men born in 1913 in Gothenburg, Sweden. J Intern Med. 2011 Apr;269(4):441-51. PUBMED: 21175902

    Persson CU, Collén AC, Rosengren A, et al. Secular trends in cardiovascular risk factors among women aged 45-54 years in Gothenburg, Sweden, from 1980 to 2014. BMC Public Health. 2020 Jul 1;20(1):1042 PUBMED: 32611406

    Timeline

    Populations

    50YMG - Men born 1913
    The population is composed of men who were born in 1913 and were 50 years of age at the time of recruitment and living in Gothenburg, Sweden.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg
    Other Criteria
    Day of birth divisible by three.
    Supplementary Information about selection criteria
    Systematic representative sample based on birth date.

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    In 1963, a sample was drawn from the Swedish population register consisting of all the men born in 1913 on a day divisible by three (e.g. the third, sixth, ninth day, and so on, of each month) and living in the city of Gothenburg.
    These criteria were met by 973 men, of whom 855 (87.9%) participated in the study.
    In addition, new cross-sectional samples of men born in 1913 and living in the city of Gothenburg were selected in 1973, 1980, 1988 and 1993 using the same criteria as in 1963.

    Sample Size

    Number of Participants
    855
    Number of Participants with Biological Samples
    855

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1913 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1963 (January) 1963 (December)
    1 50YMG - Men born 1913 - Follow-up 1
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1967 (January) 1967 (December)
    2 50YMG - Men born 1913 - Follow-up 2
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1973 (January) 1973 (December)
    3 50YMG - Men born 1913 - Follow-up 3
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1980 (January) 1980 (December)
    4 50YMG - Men born 1913 - Follow-up 4
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1988 (January) 1988 (December)
    5 50YMG - Men born 1913 - Follow-up 5
    • Questionnaires
    • Physical measures
    • Biosamples
    • Administrative databases
    • Other : Journal reviews.
    • Blood
    1993 (January) 1993 (December)
    7 50YMG - Men born 1913 - Follow-up 6
    • Administrative databases
    2011 (January) 2011 (December)
    50YMG - Women born 1953
    The population is composed of women born in 1953 and 50 years of age at the time of recruitment and living in Gothenburg, Sweden.

    Selection Criteria

    Sex
    Women only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    In 2003 every third of all women born in 1953 were invited to participate in the study.

    Sample Size

    Number of Participants
    667
    Number of Participants with Biological Samples
    667

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Women born 1953 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    2003 2003
    1 50YMG - Women born 1953 - Follow-up 1
    • Administrative databases
    2021 2021
    50YMG - Sons of men born 1913
    The population consits on men aged 30 and living in Gothenburg, sons to men born in 1913 recruited in the study in 1963.

    Selection Criteria

    Sex
    Men only
    Minimum age
    30
    Countries
    • Sweden
    Territory
    Gothenburg
    Other Criteria
    Individuals are the sons to men born 1913 in Gothenburg and recruited to the study in 1963.

    Sources of Recruitment

    Specific Population
    • Other specific population : 30-year-old sons to men born in 1913 and living in Gothenburg.
    Supplementary Information
    In 1973, 30-year-old sons to the 50YMG - born 1913 population recruited in 1963, were asked to participate in a baseline examination. Only 263 subjects met the age selection criteria and were included in the study. In 1980, a new sample of 30-year-old sons to men born in 1913 were recruited via the National Board of Health and Welfare's register.

    Sample Size

    Number of Participants
    33,263
    Number of Participants with Biological Samples
    33,263
    Supplementary information about number of participants
  • 263 participants recruited in 1973
  • 33000 participants recruited in 1980
  • Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    1 50YMG - Sons of men born 1913 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1973 (January) 1980 (December)
    2 50YMG - Sons of men born 1913 - Follow-up 1
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1988 (January) 1988 (December)
    2 50YMG - Sons of men born 1913 - Follow-up 2
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1993 (January) 1993 (December)
    3 50YMG - Sons of men born 1913 - Follow-up 3
    • Administrative databases
    2011 (January) 2011 (December)
    4 50YMG - Sons of men born 1913 - Follow-up 4
    • Administrative databases
    2021 (January) 2021 (December)
    50YMG - Men born 1923
    The population consists of men born in 1923, aged 50 and living in the city of Gothenburg.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg
    Other Criteria
    Day of birth divisible by nine.

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    Systematic representative sample based on birth date. Participation rate 77.4%

    Sample Size

    Number of Participants
    226
    Number of Participants with Biological Samples
    226

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1923 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1973 (January) 1973 (December)
    1 50YMG - Men born 1923 - Follow-up 1
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1980 (January) 1980 (December)
    2 50YMG - Men born 1923 - Follow-up 2
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1988 (January) 1988 (December)
    3 50YMG - Men born 1923 - Follow-up 3
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1993 (January) 1993 (December)
    4 50YMG - Men born 1923 - Follow-up 4
    • Administrative databases
    2011 (January) 2011 (December)
    5 50YMG - Men born 1923 - Follow-up 5
    • Administrative databases
    2021 (January) 2021 (December)
    50YMG - Men born 1933
    The population consists of men born in 1933, aged 50, and living in the city of Gothenburg.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg

    Sources of Recruitment

    General Population
    • Selected sample
    Supplementary Information
    Randomly selected population sample. Participation rate 76.4%.

    Sample Size

    Number of Participants
    776
    Number of Participants with Biological Samples
    776

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1933 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1983 (January) 1984 (December)
    1 50YMG - Men born 1933 - Follow-up 1
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1991 (January) 1992 (December)
    50YMG - Men born 1943
    The population consists of men born in 1943, aged 50, and living in the city of Gothenburg.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    Random population sample. Participation rate 54.5%

    Sample Size

    Number of Participants
    798
    Number of Participants with Biological Samples
    798

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1943 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    1993 (January) 1994 (December)
    1 50YMG - Men born 1943 - Follow-up 1
    • Questionnaires
    • Physical measures
    • Biosamples
    • Administrative databases
    • Blood
    2003 (January) 2003 (December)
    2 50YMG - Men born 1943 - Follow-up 2
    • Questionnaires
    • Physical measures
    • Biosamples
    • Administrative databases
    • Blood
    2014 (January) 2014 (December)
    3 50YMG - Men born 1943 - Follow-up 3
    • Administrative databases
    2021 (January) 2021 (December)
    50YMG - Men born 1953
    The population consists of men born in 1953, aged 50, and living in the city of Gothenburg.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    Random population sample. Participation rate 59.9%

    Sample Size

    Number of Participants
    677
    Number of Participants with Biological Samples
    677

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1953 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    2003 (January) 2004 (December)
    1 50YMG - Men born 1953 - Follow-up
    • Administrative databases
    2021 (January) 2021 (December)
    50YMG - Men born 1963
    The population consists of men born in 1963, aged 50, and living in the city of Gothenburg.

    Selection Criteria

    Sex
    Men only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    Random population sample. Participation rate 48.2%

    Sample Size

    Number of Participants
    313
    Number of Participants with Biological Samples
    313

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Men born 1963 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    2013 (January) 2014 (December)
    1 50YMG - Men born 1963 - Follow-up
    • Administrative databases
    2021 (January) 2021 (December)
    50YMG - Women born 1963
    The population consists of 50-year-old women born in 1963 and living in the city of Gothenburg, Sweden.

    Selection Criteria

    Sex
    Women only
    Minimum age
    50
    Countries
    • Sweden
    Territory
    Gothenburg
    Other Criteria
    Every fifth woman born in 1963.

    Sources of Recruitment

    General Population
    • Volunteer enrolment
    Supplementary Information
    Participation rate 53%.

    Sample Size

    Number of Participants
    343
    Number of Participants with Biological Samples
    343

    Data Collection Events

    # Name Data sources Data sources - Biosamples Start End
    0 50YMG - Women - born 1963 - Baseline
    • Questionnaires
    • Physical measures
    • Biosamples
    • Blood
    2013 (October) 2014 (April)

    Participating Studies

    Acronym Name Study design Countries

    Harmonization Initiatives Included

    Acronym Name

    Datasets

    Name Data Collection Events Variables

    Areas of Information Collected

    Socio-demographic and economic characteristics
    Death
    Lifestyle and behaviours
    Physical measures and assessments
    Birth, pregnancy and reproductive health history
    Laboratory measures
    Perception of health, quality of life, development and functional limitations
    Cognition, personality and psychological measures and assessments
    Diseases
    Life events, life plans, beliefs and values
    Symptoms and signs
    Preschool, school and work life
    Medication and supplements
    Social environment and relationships
    Non-pharmacological interventions
    Physical environment
    Health and community care services utilization
    Administrative information

    Variables Content Summary

    Areas of Information Collected
    No Areas of Information Collected
    No Scales Collected
    Areas of Information Collected per per Population and Data Collection Event
    No Areas of Information Collected
    No Scales Collected

    Networks

    Acronym Name Harmonization Initiatives Individual Studies
    Last Update: 2023-08-10T18:18:34.748