Avon Longitudinal Study of Parents and Children

The original aim of ALSPAC was to determine which biological, environmental, social, psychological and psychosocial factors are associated with the survival and optimal health and development of the fetus, infant and child, and the ways in which causal relationships might vary with the genetic composition of mother and/or child.

To identify the complex ways in which environmental features may be associated with the optimal development, health and well-being of the child, will involve a study of the ways in which genes and the environment interact. A child's ability to meet environmental and social challenges is influenced by genetic variation, but the interactions are complex. Genetic susceptibility or resistance to common disorders is likely to be bestowed by one or more genetic polymorphisms, the impact of which will change as various environmental and developmental stresses on the child change. ALSPAC was specifically designed to analyse this interplay between genes and environment with respect to important relatively common health outcomes.

Overview

Acronym
ALSPAC
Website
ALSPAC
Investigators
Prof. Paul Burton
Newcastle University
Prof. George Smith
University of Bristol
Dr Nicholas Timpson
University of Bristol
Contacts
Lynn Molloy
University of Bristol

General Design

Study design
Cohort
Start - End Year
1990 -
General Information on Follow Up (profile, frequency)

During the index pregnancy, most women were sent 3 questionnaires. Since then, over a period of some 25 years, women have been sent 22 additional questionnaires that refer to their own health and well-being. Since 2008, women have attended four focus clinical ssessments

Assessments of the children have been administered frequently, with 64 data collection time points between birth and 24 years of age. These include 34 child-completed questionnaires, 20 focus clinical assessments and 23 questionnaires about the child completed by the mother or other main caregiver.

Partners have been sent 17 questionnaires and have attended 1 focus clinic assessment.

Siblings and grandparents have been recruited.

Recruitment Target
  • Families
Number of Participants
42,710
Number of Participants with Biological Samples
22,000 (No Limit)
Supplementary information about number of participants

ALSPAC recruited 14,541 pregnant women resident in Avon, UK with expected dates of delivery 1st April 1991 to 31st December 1992.  14,541 is the initial number of pregnancies for which the mother enrolled in the ALSPAC study and had either returned at least one questionnaire or attended a “Children in Focus” clinic by 19/07/99. Of these initial pregnancies, there was a total of 14,676 fetuses, resulting in 14,062 live births and 13,988 children who were alive at 1 year of age.

When the oldest children were approximately 7 years of age, an attempt was made to bolster the initial sample with eligible cases who had failed to join the study originally. As a result, when considering variables collected from the age of seven onwards (and potentially abstracted from obstetric notes) there are data available for more than the 14,541 pregnancies mentioned above.

The number of new pregnancies not in the initial sample (known as Phase I enrolment) that are currently represented on the built files and reflecting enrolment status at the age of 18 is 706 (452 and 254 recruited during Phases II and III respectively), resulting in an additional 713 children being enrolled. The phases of enrolment are described in more detail in the cohort profile paper which should be used for referencing purposes: <http://ije.oxfordjournals.org/content/early/2012/04/14/ije.dys064.full.pdf+html>.

 The total sample size for analyses using any data collected after the age of seven is therefore 15,247 pregnancies, resulting in  15,458 fetuses.  Of this total sample of 15,458 fetuses, 14,775 were live births and 14,701 were alive at 1 year of age.

 A 10% sample of the ALSPAC cohort, known as the Children in Focus (CiF) group, attended clinics at the University of Bristol at various time intervals between 4 to 61 months of age. The CiF group were chosen at random from the last 6 months of ALSPAC births (1432 families attended at least one clinic). Excluded were those mothers who had moved out of the area or were lost to follow-up, and those partaking in another study of infant development in Avon.

 

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Marker Papers

Boyd A., Golding J., Macleod J., Lawlor D.A., Fraser A., Henderson J., Molloy L., Ness A., Ring S., Davey Smith G. Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology 2012;1-17

PUBMED 22507743

Timeline

Populations

ALSPAC - Mothers

The population consists of all pregnant women residents in the old administrative county of Avon, in the South West of England, with an expected date of delivery between 1 April 1991 and 31 December 1992.

Selection Criteria

Sex
Women only
Pregnant Women
  • First trimester
  • Second trimester
  • Third trimester
Countries
  • United Kingdom
Territory

Old administrative county of Avon, South West England.

Sources of Recruitment

General Population
  • Volunteer enrolment
Specific Population
  • Clinic patients
Supplementary Information

ALSPAC attempted to make contact with eligible women through media information encouraging study contact and recruitment staff visiting community locations. In parallel, routine antenatal and maternity health services were used to promote the study and distribute an ‘expression of interest’ card. Through returning this card, women were able to request further information on the study or to decline participation. Completed cards contained sufficient detail to allow ALSPAC staff to determine eligibility.

Posters were printed for display in a variety of different places - including chemist shops, libraries, mother and toddler groups, and pre-school playgroups, general practitioner waiting-rooms, antenatal clinics and any other area where a mother in early pregnancy was likely to be. In addition, there was considerable local and national coverage in the press, radio and television.

Sample Size

Number of Participants
14,541
Number of Participants with Biological Samples
10,000 (No Limit)

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Mothers - Biosample collection 1990 to 1992
  • Biosamples
  • Blood
  • Urine
1990 (July) 1992 (March)
1 ALSPAC - Mothers - 8 to 42 weeks gestation
  • Questionnaires
  • Physical measures
  • Administrative databases
  • Other : Obstetric clinical records
1990 (September) 1992 (October)
2 ALSPAC - Mothers - 18 weeks gestation
  • Questionnaires
  • Administrative databases
1990 (November) 1992 (September)
3 ALSPAC - Mothers - 12 weeks gestation
  • Questionnaires
  • Administrative databases
1990 (November) 1993 (August)
4 ALSPAC - Mothers - 32 weeks gestation
  • Questionnaires
  • Administrative databases
1991 (March) 1993 (January)
5 ALSPAC - Mothers - 8 weeks
  • Questionnaires
  • Administrative databases
  • Other : Obstetric medical records
1991 (May) 1993 (April)
6 ALSPAC - Mothers - 8 months
  • Questionnaires
  • Administrative databases
1992 (April) 1993 (October)
7 ALSPAC - Mothers - 21 months
  • Questionnaires
  • Administrative databases
1992 (September) 1994 (November)
8 ALSPAC - Mothers - 33 months
  • Questionnaires
  • Administrative databases
1993 (October) 1995 (November)
9 ALSPAC - Mothers - Biosample collection 1993
  • Biosamples
  • Hair
  • Nail
1993 (November) 1993 (November)
10 ALSPAC - Mothers - 47 months
  • Questionnaires
  • Administrative databases
1994 (November) 1997 (January)
11 ALSPAC - Mothers - 61 months
  • Questionnaires
  • Administrative databases
1996 (January) 1998 (March)
12 ALSPAC - Mothers - 73 months
  • Questionnaires
  • Administrative databases
1997 (February) 1999 (March)
13 ALSPAC - Mothers - 85 months
  • Questionnaires
  • Administrative databases
1998 (August) 2000 (March)
14 ALSPAC - Mothers - 97 months
  • Questionnaires
  • Administrative databases
1999 (September) 2001 (May)
15 ALSPAC - Mothers - 110 months
  • Questionnaires
  • Administrative databases
2000 (October) 2002 (April)
16 ALSPAC - Mothers - 122 months
  • Questionnaires
  • Administrative databases
2001 (August) 2003 (April)
17 ALSPAC - Mothers - 134 months
  • Questionnaires
  • Administrative databases
2002 (July) 2004 (May)
18 ALSPAC - Mothers - 145 months
  • Questionnaires
  • Administrative databases
2003 (May) 2005 (May)
19 ALSPAC - Mothers - Biosample collection 2004 to 2008
  • Biosamples
  • Blood
  • Urine
2004 2008
20 ALSPAC - Mothers - 156 months
  • Questionnaires
  • Administrative databases
2004 (May) 2004 (October)
21 ALSPAC - Mothers - Focus on mothers 1
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
2008 (December) 2011 (July)
22 ALSPAC - Mothers - 18 years
  • Questionnaires
  • Administrative databases
2009 (May) 2010 (September)
23 ALSPAC - Mothers - Focus on mothers 2
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
2011 (July) 2013 (June)
24 ALSPAC - Mothers - 20 years
  • Questionnaires
  • Administrative databases
2011 (September) 2012 (February)
25 ALSPAC - Mothers - 22 years
  • Questionnaires
  • Administrative databases
2012 (September) 2014 (December)
26 ALSPAC - Mothers - Focus on mothers 3
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
2013 (March) 2014 (March)
27 ALSPAC - Mothers - Focus on mothers 4
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
2014 (April) 2015 (March)
ALSPAC - Partners

The population consists of partners; whether it is the biological fathers or those who take on the role of a parent of the children enrolled in the study.

Selection Criteria

Countries
  • United Kingdom
Territory

Old administrative county of Avon.

Sources of Recruitment

Specific Population
  • Other specific population :

    Mothers’ partners or fathers of the children recruited in ALSPAC.

Sample Size

Number of Participants
10,207
Number of Participants with Biological Samples
1,000
Supplementary information about number of participants

Partners of the mothers were invited to complete self completion questionnaires from pregnancy onwards by the mother.

Fathers were then enrolled into the study in their own right - 3000 were enrolled in 2010 and were invited to attend a hands-on clinical assessment and complete further questionnaries.

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Partners - 18 weeks gestation
  • Questionnaires
1990 (November) 1992 (September)
1 ALSPAC - Partners - 12 weeks gestation
  • Questionnaires
1990 (November) 1993 (August)
2 ALSPAC - Partners - 8 weeks
  • Questionnaires
1991 (May) 1993 (April)
3 ALSPAC - Partners - 8 months
  • Questionnaires
1992 (April) 1993 (October)
4 ALSPAC - Partners - 21 months
  • Questionnaires
1992 (September) 1994 (November)
5 ALSPAC - Partners - 33 months
  • Questionnaires
1993 (October) 1995 (November)
6 ALSPAC - Partners - Biosample collection 1993
  • Biosamples
  • Hair
  • Nail
1993 (November) 1993 (November)
7 ALSPAC - Partners - 47 months
  • Questionnaires
1994 (November) 1997 (January)
8 ALSPAC - Partners - 61 months
  • Questionnaires
1996 (January) 1998 (March)
9 ALSPAC - Partners - 73 months
  • Questionnaires
1997 (February) 1999 (March)
10 ALSPAC - Partners - 85 months
  • Questionnaires
1998 (August) 2000 (March)
11 ALSPAC - Partners - 97 months
  • Questionnaires
1999 (September) 2001 (May)
12 ALSPAC - Partners - 110 months
  • Questionnaires
2000 (October) 2002 (April)
13 ALSPAC - Partners - 122 months
  • Questionnaires
2001 (August) 2003 (April)
14 ALSPAC - Partners - 134 months
  • Questionnaires
2002 (July) 2004 (May)
15 ALSPAC - Partners - 145 months
  • Questionnaires
2003 (May) 2005 (May)
16 ALSPAC - Partners - Biosample collection 2004-2008
  • Biosamples
  • Blood
2004 (January) 2008 (December)
17 ALSPAC - Partners - 156 months
  • Questionnaires
2004 (May) 2004 (October)
18 ALSPAC - Partners - Biosample collection 2010
  • Biosamples
  • Blood
2010 (May) 2010 (May)
19 ALSPAC - Partners - 20 years
  • Questionnaires
2011 (January) 2012 (December)
20 ALSPAC - Partners - 21/22 years
  • Questionnaires
2011 (September) 2013 (February)
21 ALSPAC - Partners - Focus on father 1
  • Physical measures
2011 (September) 2013 (February)
ALSPAC - Children

The population consists of any resulting child from all pregnant women residents in the old administrative county of Avon if their estimated delivery date fell between 1 April 1991 and 31 December 1992.

Selection Criteria

Newborns
Countries
  • United Kingdom
Territory

Old administrative county of Avon, South West England.

Sources of Recruitment

Specific Population
  • Other specific population :

    Children of the mothers recruited in ALSPAC.

Sample Size

Number of Participants
14,062
Number of Participants with Biological Samples
10,000 (No Limit)

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Children - Biosample collection birth
  • Biosamples
  • Blood
  • Tissues : cord slices
  • Other : placenta
1991 (April) 1992 (December)
1 ALSPAC - Children - 4 weeks
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages, Obstetric clinical records
1991 (April) 1993 (April)
2 ALSPAC - Children - 6 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1991 (July) 1993 (August)
3 ALSPAC - Children - Biosample collection 6 to 18 months
  • Biosamples
  • Hair
  • Nail
1991 (October) 1994 (June)
4 ALSPAC - Children - 15 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1992 (August) 1994 (May)
5 ALSPAC - Children - Children in focus 4 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
1992 (October) 1993 (April)
6 ALSPAC - Children - 18 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1992 (October) 1994 (August)
7 ALSPAC - Children - 24 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1993 (January) 1995 (February)
8 ALSPAC - Children - Children in focus 8 months
  • Questionnaires
  • Physical measures
1993 (February) 1993 (August)
9 ALSPAC - Children - Children in focus 12 months
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
1993 (June) 1993 (December)
10 ALSPAC - Children - Children in focus 18 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
1993 (December) 1994 (June)
11 ALSPAC - Children - 30 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1994 (January) 1995 (August)
12 ALSPAC - Children - 38 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1994 (March) 1996 (April)
13 ALSPAC - Children - Biosample collection 3 years
  • Biosamples
  • Hair
  • Nail
1994 (April) 1995 (December)
14 ALSPAC - Children - Children in focus 25 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
1994 (July) 1995 (January)
15 ALSPAC - Children - 42 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1994 (July) 1996 (October)
16 ALSPAC - Children - Children in focus 31 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
1995 (January) 1995 (July)
17 ALSPAC - Children - Biosample collection 4 years
  • Biosamples
  • Hair
  • Nail
1995 (April) 1996 (December)
18 ALSPAC - Children - Children in focus 37 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
1995 (July) 1996 (January)
19 ALSPAC - Children - 54 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
1995 (July) 1997 (August)
20 ALSPAC - Children - Children in focus 43 months
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
1996 (January) 1996 (July)
21 ALSPAC - Children - 57 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1996 (January) 1997 (November)
22 ALSPAC - Children - Biosample collection 5 to 7 years
  • Biosamples
  • Other : Teeth
1996 (April) 1999 (December)
23 ALSPAC - Children - Children in focus 49 months
  • Cognitive measures
  • Physical measures
1996 (July) 1997 (January)
24 ALSPAC - Children - 65 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
1996 (October) 1998 (July)
25 ALSPAC - Children - 69 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1997 (February) 1998 (December)
26 ALSPAC - Children - 73 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
1997 (February) 1999 (March)
27 ALSPAC - Children - Children in focus 61 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
1997 (July) 1998 (April)
28 ALSPAC - Children - 77 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
1997 (November) 1999 (July)
29 ALSPAC - Children - 81 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1998 (March) 1999 (November)
30 ALSPAC - Children - Biosample collection 7 to 8 years
  • Biosamples
  • Blood
  • Urine
1998 (April) 2000 (December)
31 ALSPAC - Children - 91 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
1998 (July) 2000 (October)
32 ALSPAC - Children - 85 months
  • Questionnaires
1998 (August) 2000 (March)
33 ALSPAC - Children - Children in focus 7 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
1998 (September) 2000 (September)
34 ALSPAC - Children - 97 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
1999 (September) 2001 (May)
35 ALSPAC - Children - Children in focus 8 years
  • Questionnaires
  • Physical measures
1999 (October) 2001 (December)
36 ALSPAC - Children - 103 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2000 (May) 2001 (September)
37 ALSPAC - Children - 110 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2000 (October) 2002 (April)
38 ALSPAC - Children - Children in focus 9 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
2001 (January) 2003 (January)
39 ALSPAC - Children - 115 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
2001 (February) 2002 (November)
40 ALSPAC - Children - 122 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2001 (November) 2003 (April)
41 ALSPAC - Children - Children in focus 10 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
  • Saliva
2002 (February) 2003 (October)
42 ALSPAC - Children - 128 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
2002 (February) 2003 (November)
43 ALSPAC - Children - 134 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2002 (July) 2004 (May)
44 ALSPAC - Children - 140 months
  • Questionnaires
  • Cognitive measures
  • Administrative databases
  • Other : Geo-spatial linkages
2002 (December) 2004 (November)
45 ALSPAC - Children - Children in focus 11 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Saliva
2003 (January) 2005 (January)
46 ALSPAC - Children - 145 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2003 (May) 2005 (May)
47 ALSPAC - Children - Teen in focus 12 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
  • Saliva
2004 (February) 2005 (November)
48 ALSPAC - Children - 157 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2004 (May) 2006 (April)
49 ALSPAC - Children - Teen in focus 13 years
  • Questionnaires
  • Physical measures
  • Biosamples
  • Blood
  • Urine
2005 (January) 2006 (September)
50 ALSPAC - Children - 166 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2005 (July) 2006 (December)
51 ALSPAC - Children - 167 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2005 (September) 2007 (January)
52 ALSPAC - Children - 169 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2006 (January) 2007 (March)
53 ALSPAC - Children - Teen in focus 15 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
  • Saliva
  • Hair
2006 (October) 2008 (November)
54 ALSPAC - Children - 192 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2007 (March) 2009 (February)
55 ALSPAC - Children - Biosample collection 17 years
  • Biosamples
  • Blood
  • Urine
  • Hair
2008 (April) 2009 (December)
56 ALSPAC - Children - 17 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2008 (April) 2010 (December)
57 ALSPAC - Children - 198 months
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2008 (October) 2009 (September)
58 ALSPAC - Children - Teen in focus 17 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
  • Saliva
  • Hair
2008 (December) 2011 (June)
59 ALSPAC - Children - 18 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2010 (September) 2011 (May)
60 ALSPAC - Children - 19 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2011 (October) 2012 (January)
61 ALSPAC - Children - Biosample collection 21 to 22 years
  • Biosamples
  • Blood
  • Urine
2012 (April) 2014 (December)
62 ALSPAC - Children - 20 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2012 (September) 2013 (July)
63 ALSPAC - Children - 21 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2013 (December) 2014 (October)
64 ALSPAC - Children - 22 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2014 (November) 2015 (October)
65 ALSPAC - Children - Biosample collection 24 to 25 years
  • Biosamples
  • Blood
  • Urine
2015 (April) 2017 (December)
66 ALSPAC - Children - Children in focus 24 years
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Blood
  • Urine
2015 (June) 2017 (September)
67 ALSPAC - Children - 23 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2015 (December) 2016 (September)
68 ALSPAC - Children - 24 years
  • Questionnaires
  • Administrative databases
  • Other : Geo-spatial linkages
2016 (November) 2017 (August)
69 ALSPAC - Children - 25 years
  • Questionnaires
2017 (November) 2018 (July)
70 ALSPAC - Children - 26 years
  • Questionnaires
2018 (November) 2019 (September)
71 ALSPAC - Children - 27 years
  • Questionnaires
2019 (November) 2020 (July)
ALSPAC - Generation 2

The population consists of the children of the children enrolled in the first generation of the study.

Selection Criteria

Countries
  • United Kingdom
Territory

Old administrative county of Avon.

Sources of Recruitment

Specific Population
  • Other specific population :

    Children of the children recruited in ALSPAC.

Sample Size

Number of Participants
1,100
Number of Participants with Biological Samples
1,000

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Generation 2 - Birth
  • Physical measures
  • Biosamples
  • Tissues : Placenta, cord
  • Other : meconium
2012 2019
1 ALSPAC - Generation 2 - 7 to 15 days
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Cord blood
  • Tissues : Placenta
  • Other : Meconium, stool
2012 2019
2 ALSPAC - Generation 2 - 6 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Stools
2012 2019
3 ALSPAC - Generation 2 - 12 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Stools
2013 2019
4 ALSPAC - Generation 2 - 24 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Administrative databases
2014 2019
5 ALSPAC - Generation 2 - 36 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Saliva
2015 2019
6 ALSPAC - Generation 2 - 48 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Administrative databases
2016 2019
7 ALSPAC - Generation 2 - 60 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Stools
2017 2019
8 ALSPAC - Generation 2 - 72 months
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Saliva
2018 2019
9 ALSPAC - Generation 2 - 84 months
  • Questionnaires
  • Physical measures
  • Administrative databases
2019 2019
ALSPAC - Siblings

The population consists of the siblings of the children enrolled in the ALSPAC study .

Selection Criteria

Countries
  • United Kingdom
Territory

Old administrative county of Avon.

Sources of Recruitment

Specific Population
  • Other specific population :

    Siblings of the children recruited in ALSPAC.

Sample Size

Number of Participants
1,800 (No Limit)
Supplementary information about number of participants

Initial target is 1800 (but not limited to this)

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Siblings - Recruitment
  • Questionnaires
  • Biosamples
  • Saliva
2014 2015
ALSPAC - Grandparents

The population consists of the grandparents of the children enrolled in the ALSPAC study.

Selection Criteria

Countries
  • United Kingdom
Territory

Old administrative county of Avon.

Sources of Recruitment

Specific Population
  • Other specific population :

    Grandparents of the children recruited in ALSPAC.

Sample Size

Number of Participants
1,000
Supplementary information about number of participants

Initital target for einrollment is 1000 (but not limited to this)

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ALSPAC - Grandparents - Recruitment
  • Questionnaires
  • Biosamples
  • Saliva
2014 (September) 2015

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2025-06-26T15:22:52.181