Study of Abnormalities Related to the Development of Self-Consciousness as a Neurodevelopmental Edophenotype of Risk for Schizophrenia, Bipolar Disorder or Recurrent Major Depression

The objectives of the study are: * To determine whether neurodevelopmental abnormalities related to self-consciousness may be candidates as a risk neurodevelopmental endophenotype in children at family risk for major psychiatric disorders (MPDs) namely schizophrenia, bipolar disorder or recurrent major depression, when compared to healthy control children. * To investigate the nature of possible neurodevelopmental abnormalities related to self-awareness to better understand how they might contribute to the psychopathophysiology of these illnesses by linking them to other clinical, cognitive and biological markers.

Overview

Acronym
BasicSx
Website
BasicSx
Investigators
Dr. Michel Maziade
CERVO Brain Research Centre, Université de Laval
Dr. Pierre Marquet
CERVO Brain Research Centre, Université Laval
Contacts
SxdeBase

General Design

Study design
Cohort
Start - End Year
2018 -
General Information on Follow Up (profile, frequency)
After the initial measurement, offsprings are followed at 3 and 6 years and adults are invited to an optional second meeting.
Recruitment Target
  • Individuals
Number of Participants
225
Supplementary information about number of participants
The sample plans to include: * At-risk Offspring: 150 participants * Control Offspring: 150 participants * MPD Adults: 50 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Timeline

Populations

BasicSx - At-risk Children
The population is composed of offspring of at least one biological parent with a documented history of Major Psychiatric Disorder (MPD), including schizophrenia, bipolar disorder, or recurrent major depressive disorder.

Selection Criteria

Minimum age
6
Maximum age
8
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
21

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - At-risk Offspring - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - At-risk Offspring - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - At-risk Offspring - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - At-risk Pre-adolescents
The population is composed of offspring of at least one biological parent with a documented history of Major Psychiatric Disorder (MPD), including schizophrenia, bipolar disorder, or recurrent major depressive disorder.

Selection Criteria

Minimum age
9
Maximum age
15
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
60

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - At-risk Pre-adolescents - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - At-risk Pre-adolescents - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - At-risk Pre-adolescents - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - At-risk Adolescents and Young Adults
The population is composed of offspring of at least one biological parent with a documented history of Major Psychiatric Disorder (MPD), including schizophrenia, bipolar disorder, or recurrent major depressive disorder.

Selection Criteria

Minimum age
16
Maximum age
24
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
14

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - At-risk Adolescents and Young Adults - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - At-risk Adolescents and Young Adults - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - At-risk Adolescents and Young Adults - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - Control Children
The population is composed of children of biological parents and siblings (first- and second-degree family) with no lifetime history of mental illness and have no family history of Major Psychiatric Disorder (MPD) according to DSM-IV or V (Diagnostic and Statistical Manual of Mental Disorders, fourth of fifth edition) in more than 2 individuals in third-degree family (grandparents, uncles, aunts).

Selection Criteria

Minimum age
6
Maximum age
8
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
50

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - Control Children - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - Control Children - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - Control Offspring - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - Control Pre-adolescents
The population is composed of children of biological parents and siblings (first- and second-degree family) with no lifetime history of mental illness and have no family history of Major Psychiatric Disorder (MPD) according to DSM-IV or V (Diagnostic and Statistical Manual of Mental Disorders, fourth of fifth edition) in more than 2 individuals in third-degree family (grandparents, uncles, aunts).

Selection Criteria

Minimum age
9
Maximum age
15
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1) Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
50

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - Control Pre-adolescents - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - Control Pre-adolescents - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - Control Pre-adolescents - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - Control Adolescents and Young Adults
The population is composed of children of biological parents and siblings (first- and second-degree family) with no lifetime history of mental illness and have no family history of Major Psychiatric Disorder (MPD) according to DSM-IV or V (Diagnostic and Statistical Manual of Mental Disorders, fourth of fifth edition) in more than 2 individuals in third-degree family (grandparents, uncles, aunts).

Selection Criteria

Minimum age
16
Maximum age
24
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
50

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - Control Adolescents and Young Adults - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - Control Adolescents and Young Adults - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2021 (November) 2030 (May)
2 BasicSx - Control Adolescents and Young Adults - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2024 (November) 2030 (May)
BasicSx - Control Adults
The population is composed of adults with no lifetime history of diagnosis including but not limited to schizophrenia, bipolar disorder, or recurrent major depressive disorder.

Selection Criteria

Minimum age
18
Maximum age
55
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT – PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
1

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - Control Adults - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - Control Adults - Optional meeting
  • Questionnaires
2018 (November) 2030 (May)
BasicSx - MPD Adults
The population is composed of adults with a primary DSM-IV or V (Diagnostic and Statistical Manual of Mental Disorders, Fourth or Fifth Edition) diagnosis including schizophrenia, bipolar disorder, or recurrent major depressive disorder.

Selection Criteria

Minimum age
18
Maximum age
55
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Intercepting the risk trajectory of cognitive and clinical endophenotypes in the prevention and treatment of schizophrenia and affective disorders (INTERCEPT - PHASE 1)
  • Longitudinal study of the bio-psycho-social functioning of a sample of adults and children from the CIUSSS de la Capitale-Nationale territory according to their personal and family mental health history (Bipso)

Sample Size

Number of Participants
28

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 BasicSx - MPD Adults - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2018 (November) 2030 (May)
1 BasicSx - MPD Adults - Optional meeting
  • Questionnaires
2018 (November) 2030 (May)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2026-02-20T13:38:39.150