British Columbia Multiple Sclerosis Historical Database
The objective of this study was to gather information about patients with suspected or diagnosed Multiple Sclerosis and related disorders, to find innovative ways to diagnose and treat patients, and to support patient treatment, education and future research.
Overview
- Acronym
- BCMS
- Website
- BCMS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1980 - 2009
- General Information on Follow Up (profile, frequency)
-
Frequency of follow-up is at the discretion of the neurologist and varied over time for each individual. Yearly clinic visits were common but patients could be seen more or less frequently, as needed.
- Recruitment Target
-
- Individuals
- Number of Participants
- 10,000
- Supplementary information about number of participants
-
Approximately 80% of people living with multiple sclerosis in British Columbia during the study period are included in this sample.
- Supplementary Information
-
Data is extracted prospectively from a collated clinical database and extensive chart reviews were performed to create the BCMS historical database, suitable for research purposes.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
Tremlett H, Zhao Y, Devonshire V. Natural history of secondary-progressive multiple sclerosis. Multiple Sclerosis, 2008; 14: 314-324.
PUBMED 18208898Supplementary Information
Other websites:
Pharmacoepidemiology in MS Research group's website'/Tremlett lab/ investigator websiteFor information on the current UBC Hospital MS Clinic Registry website
Other articles:
Wijnands JMA, Kingwell E, Zhu F, et al. Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort study. Lancet Neurol, 2017; Jun 16(6): 445-451.
Shirani, A, Zhao Y, Karim M, et al. Association between use of beta-interferon and progression of disability in patients with relapsing-remitting multiple sclerosis. Journal of the American Medical Association (JAMA), 2012; Jul 18; 308(3): 247-256.
Tremlett H, Paty D, Devonshire V. Disability progression in MS is slower than previously reported. Neurology, 2006; 66: 172-177.
Zhang T, Tremlett H, Zhu F, Kingwell E, Fisk J, Bhan V, Campbell T, Stadnyk K, Carruthers R, Wolfson C, Warren S, Marrie RA for the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis. Effects of physical comorbidities on disability progression in multiple sclerosis. Neurology. 2018; Jan 30;90(5):e419-e427.
Kowalec K, McKay K, Patten S, Fisk J, Evans C, Tremlett H, Marrie RA, for the CIHR Team in Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS).Comorbidity increases the risk of relapse in multiple sclerosis: A prospective study. Neurology. 2017; 12;89(24):2455-2461.
McKay K, Tremlett H, Fisk J, Zhang T, Patten S, Kastrukoff L, Campbell T, Marrie RA; CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis. Psychiatric comorbidity is associated with disability progression in multiple sclerosis. Neurology. 2018 Apr 10;90(15):e1316-e1323
Timeline
Population
BCMS population
The population consisted of persons who visited a Multiple Sclerosis clinic in British Columbia, Canada and were diagnosed by a neurologist as having MS using internationally recognized criteria (Poser or McDonald).
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- British Columbia
- Health Status
-
- Multiple sclerosis status must be "definite", "probable", or "possible".
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Pariticants are recruited in four multiple sclerosis clinics across British Columbia.
Sample Size
- Number of Participants
- 10,000
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | BCMS - Enrollment |
|
1980 (January) | 2004 (December) | |
| 1 | BCMS - Follow-up 1 |
|
1981 (January) | 1982 (December) | |
| 2 | BCMS - Follow-up 2 |
|
1982 (January) | 1983 (December) | |
| 3 | BCMS - Follow-up 3 |
|
1983 (January) | 1984 (December) | |
| 4 | BCMS - Follow-up 4 |
|
1984 (January) | 1985 (December) | |
| 5 | BCMS - Follow-up 5 |
|
1985 (January) | 1986 (December) | |
| 6 | BCMS - Follow-up 6 |
|
1986 (January) | 1987 (December) | |
| 7 | BCMS - Follow-up 7 |
|
1987 (January) | 1988 (December) | |
| 8 | BCMS - Follow-up 8 |
|
1988 (January) | 1989 (December) | |
| 9 | BCMS - Follow-up 9 |
|
1989 (January) | 1990 (December) | |
| 10 | BCMS - Follow-up 10 |
|
1990 (January) | 1991 (December) | |
| 11 | BCMS - Follow-up 11 |
|
1991 (January) | 1992 (December) | |
| 12 | BCMS - Follow-up 12 |
|
1992 (January) | 1993 (December) | |
| 13 | BCMS - Follow-up 13 |
|
1993 (January) | 1994 (December) | |
| 14 | BCMS - Follow-up 14 |
|
1994 (January) | 1995 (December) | |
| 15 | BCMS - Follow-up 15 |
|
1995 (January) | 1996 (December) | |
| 16 | BCMS - Follow-up 16 |
|
1996 (January) | 1997 (December) | |
| 17 | BCMS - Follow-up 17 |
|
1997 (January) | 1998 (December) | |
| 18 | BCMS - Follow-up 18 |
|
1998 (January) | 1999 (December) | |
| 19 | BCMS - Follow-up 19 |
|
1999 (January) | 2000 (December) | |
| 20 | BCMS - Follow-up 20 |
|
2000 (January) | 2001 (December) | |
| 21 | BCMS - Follow-up 21 |
|
2001 (January) | 2002 (December) | |
| 22 | BCMS - Follow-up 22 |
|
2002 (January) | 2003 (December) | |
| 23 | BCMS - Follow-up 23 |
|
2003 (January) | 2004 (December) | |
| 24 | BCMS - Follow-up 24 |
|
2004 (January) | 2005 (December) | |
| 25 | BCMS - Follow-up 25 |
|
2005 (January) | 2006 (December) | |
| 26 | BCMS - Follow-up 26 |
|
2006 (January) | 2007 (December) | |
| 27 | BCMS - Follow-up 27 |
|
2007 (January) | 2008 (December) | |
| 28 | BCMS - Follow-up 28 |
|
2008 (January) | 2009 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-03-18T15:00:12.957