At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, urine sample) were taken as well.

At Testwave 2 (T2), participants from Sample 1 (S1) returned for testing and those samples 2 (S2) and 3 (S3), were randomly selected and invited.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood sample) were taken as well.

At Testwave 3 (T3) participants from Samples S1, S2 and S3 returned for testing while another sample, S4, was randomly selected and invited to participate.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At Testwave 4 (T4) participants from samples S1 and S3 returned for testing while another sample, S5, was randomly selected and invited to participate.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At T5 participants from S1 and S3 returned for testing. At this test wave, another sample, S6, was randomly selected and invited.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At Testwave 6 (T6) participants from S1, S3, and S6 returned for testing.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood, saliva and urine sample) were taken as well.

At each data collection time point, participants came to the Betula lab twice. The first visit consisted primarily of an extensive health examination and the second visit consisted mainly of testing cognitive functions.

The questionnaires collected information about health status, subjective health, physical and mental symptoms (heart pain, back pain, stomach pain, difficulties in sleeping, feelings of loneliness, anxiety), health care consumption, use of prescribed medication, explorations of daily living, leisure activities, critical life events, and other social and economic factors.

The cognitive functions testing included examination of episodic and prospective memory (face and name recognition, action memory, sentence memory, word recall with or without a distractor task, source recall and memory for activities), semantic memory (general knowledge questions, vocabulary test, four-word fluency test) and unconscious forms of memory (one word-stem completion task, four-word fluency test).

Physical measures (blood pressure, pulse rate, sensory function) were taken.

Biosamples collection (blood and urine sample) were taken as well.