Betula Study

Overview

Acronym
Betula
Website
Betula
Investigators
  • Prof. Lars Nyberg

    Umeå universitet

  • Dr. Anna Sundström

    Umeå universitet

  • Dr. Michael Rönnlund

    Umeå universitet

  • Pr. Rolf Adolfsson

    Umeå universitet

Contacts
  • Mikael Stiernstedt

    Umeå universitet

General Design

Study design
Cohort
Start Year
1988
End Year
2014
General Information on Follow Up (profile, frequency)
The participants were assessed at 6 different time points every 5 years: in 1988-1990, 1993-1995, 1998-2000, 2003-2005, 2008-2010 and 2013-2014.
Recruitment Target
  • Individuals
Number of Participants
4,425
Number of Participants with Biological Samples
4,300

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

1. Zimbardo Time Perspective Inventory Based on: (ZTPI) Zimbardo o. Boyds skala (Zimbardo, P., and Boyd, J. N. (1999). Used in Betula: Carelli, M. G., Wiberg, B., & Wiberg, M. (2011). Development and Construct Validation of the Swedish Zimbardo Time Perspective Inventory. European Journal of Psychological Assessment, 27(4), 220–227. https://doi.org/10.1027/1015-5759/a000076

2. Patient Health Questionnaire-9 Based on: Kroenke, K., Spitzer, RL. & Willimas, JB. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x Used in Betula: translated version.

3. Perceived Stress Questionnaire Based on: Levenstein S, Prantera C, Varvo V, Scribano ML, Berto E, Luzi C, Andreoli A. Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. J Psychosom Res 1993;37:19–32. https://doi.org/10.1016/0022-3999(93)90120-5.

Bergdahl, J., and Bergdahl, M. (2002). Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. Stress Health 18, 235–241. doi: 10.1002/smi.946 Used in Betula: translated version.

4. Seasonal Pattern Assessment Questionnaire Based on: Rosenthal, NE., Sack, DA., Gillin, JC., Lewy AJ., Goodwin, FK., Davenport, Y., Mueller, PS., Newsome, DA. & Wehr, TA. (1984). Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry, 41(1), 72-80. https://doi.org/10.1001/archpsyc.1984.01790120076010 Used in Betula: translated version

Marker Paper

Nilsson L-G, Adolfsson R, Bäckman L, de Frias C, Molander B, Nyberg L. Betula: A Prospective Cohort Study on Memory, Health and Aging. Aging, Neuropsychology and Cognition,2004; 11 (2-3), 134-148.

Supplementary Information

Nilsson, L.-Gör., Bäckman, L., Erngrund, K., et al. The Betula Prospective Cohort Study: Memory, Health, and Aging. Aging, Neuropsychology, and Cognition,1997; 4(1), 1–32.

Timeline

Populations

Betula - Cohort 1

Selection Criteria

Minimum age
35
Maximum age
80
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. The study began with including 1000 randomly selected individuals from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.

Sample Size

Number of Participants
1,000
Supplementary Information
T1: 1000 participants
T2: 875 participants
T3: 729 participants
T4: 591 participants
T5: 403 participants
T6: 249 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 1 - T1 1988 (November) 1991 (April)
1 Betula - Cohort 1 - T2 1993 (September) 1995 (September)
2 Betula - Cohort 1 - T3 1998 (September) 2001 (March)
3 Betula - Cohort 1 - T4 2003 (September) 2005 (November)
4 Betula - Cohort 1 - T5 2008 (October) 2010 (March)
5 Betula - Cohort 1 - T6 2013 (September) 2014 (July)
Betula - Cohort 2

Selection Criteria

Minimum age
35
Maximum age
80
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.

Sample Size

Number of Participants
994
Supplementary Information
T1: 994 participants
T2: 681 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 2 - T1 1993 (September) 1995 (September)
1 Betula - Cohort 2 - T2 1998 (September) 2001 (March)
Betula - Cohort 3

Selection Criteria

Minimum age
40
Maximum age
84
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 40, 45, 50, 55, 60, 65, 70, 75, 80 and 85 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.

Sample Size

Number of Participants
963
Supplementary Information
T1: 963 participants
T2: 826 participants
T3: 689 participants
T4: 440 participants
T5: 259 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 3 - T1 1993 (September) 1995 (September)
1 Betula - Cohort 3 - T2 1998 (September) 2001 (March)
2 Betula - Cohort 3 - T3 2003 (September) 2005 (November)
3 Betula - Cohort 3 - T4 2008 (October) 2010 (March)
4 Betula - Cohort 3 - T5 2013 (September) 2014 (July)
Betula - Cohort 4

Selection Criteria

Minimum age
35
Maximum age
90
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 and 90 years. In each age group, roughly 50 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.

Sample Size

Number of Participants
553
Supplementary Information
T1: 553 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 4 - T1 1998 (September) 2001 (March)
Betula - Cohort 5

Selection Criteria

Minimum age
35
Maximum age
95
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90 and 95 years. In each age group, roughly 45 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population

Sample Size

Number of Participants
558
Supplementary Information
T1: 558 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 5 - T1 2003 (September) 2005 (November)
Betula - Cohort 6

Selection Criteria

Minimum age
25
Maximum age
80
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Other Criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 360 randomly selected individuals were recruited from the Umeå municipality in the age groups 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 30 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.

Sample Size

Number of Participants
357
Supplementary Information
T1: 357 participants
T2: 66 participants

Data Collection Events

# Name Description Start End
0 Betula - Cohort 6 - T1 2008 (October) 2010 (March)
1 Betula - Cohort 6 - T2 2013 (September) 2014 (July)

Individual Studies Included

Acronym Name Study design Participants Countries

Harmonization Projects Included

Acronym Name

Networks

Acronym Name Studies

Datasets

Name Type Data Collection Events Variables
Last Update: 2021-07-26 20:33