Betula Study
- The main objectives of Betula study are:
- To study how memory functions change during adult life and old age;
- To identify risk factors for dementia;
- To identify early preclinical signs of dementia.
Overview
- Acronym
- Betula
- Website
- Betula
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1988 - 2014
- General Information on Follow Up (profile, frequency)
-
The participants were assessed at 6 different time points every 5 years: in 1988-1990, 1993-1995, 1998-2000, 2003-2005, 2008-2010 and 2013-2014.
- Recruitment Target
-
- Individuals
- Number of Participants
- 4,425
- Number of Participants with Biological Samples
- 4,300
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
A sub-sample of participants underwent MRI brain scanning at test wave 5 (2009-2010) and 6 (2013-2014).
1. Zimbardo Time Perspective Inventory Based on: (ZTPI) Zimbardo o. Boyds skala (Zimbardo, P., and Boyd, J. N. (1999). Used in Betula: Carelli, M. G., Wiberg, B., & Wiberg, M. (2011). Development and Construct Validation of the Swedish Zimbardo Time Perspective Inventory. European Journal of Psychological Assessment, 27(4), 220–227. https://doi.org/10.1027/1015-5759/a000076
2. Patient Health Questionnaire-9 Based on: Kroenke, K., Spitzer, RL. & Willimas, JB. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x Used in Betula: translated version.
3. Perceived Stress Questionnaire Based on: Levenstein S, Prantera C, Varvo V, Scribano ML, Berto E, Luzi C, Andreoli A. Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. J Psychosom Res 1993;37:19–32. https://doi.org/10.1016/0022-3999(93)90120-5.
Bergdahl, J., and Bergdahl, M. (2002). Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. Stress Health 18, 235–241. doi: 10.1002/smi.946 Used in Betula: translated version.
4. Seasonal Pattern Assessment Questionnaire Based on: Rosenthal, NE., Sack, DA., Gillin, JC., Lewy AJ., Goodwin, FK., Davenport, Y., Mueller, PS., Newsome, DA. & Wehr, TA. (1984). Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry, 41(1), 72-80. https://doi.org/10.1001/archpsyc.1984.01790120076010 Used in Betula: translated version
Marker Paper
Nilsson L-G, Adolfsson R, Bäckman L, de Frias C, Molander B, Nyberg L. Betula: A Prospective Cohort Study on Memory, Health and Aging. Aging, Neuropsychology and Cognition,2004; 11 (2-3), 134-148.
Supplementary Information
Nilsson, L.-Gör., Bäckman, L., Erngrund, K., et al. The Betula Prospective Cohort Study: Memory, Health, and Aging. Aging, Neuropsychology, and Cognition,1997; 4(1), 1–32.
Timeline
Populations
Betula - Cohort 1
The population consists of randomly selected individuals aged from 35 to 80 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
35
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. The study began with including 1000 randomly selected individuals from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 1,000
- Supplementary Information about selection criteria
-
T1: 1000 participants
T2: 875 participants
T3: 729 participants
T4: 591 participants
T5: 403 participants
T6: 249 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 1 - T1 |
|
|
1988 (November) | 1991 (April) |
| 1 | Betula - Cohort 1 - T2 |
|
|
1993 (September) | 1995 (September) |
| 2 | Betula - Cohort 1 - T3 |
|
|
1998 (September) | 2001 (March) |
| 3 | Betula - Cohort 1 - T4 |
|
|
2003 (September) | 2005 (November) |
| 4 | Betula - Cohort 1 - T5 |
|
|
2008 (October) | 2010 (March) |
| 5 | Betula - Cohort 1 - T6 |
|
|
2013 (September) | 2014 (July) |
Betula - Cohort 2
The population consists of randomly selected individuals aged from 35 to 80 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
35
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 994
- Supplementary Information about selection criteria
-
T1: 994 participants
T2: 681 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 2 - T1 |
|
|
1993 (September) | 1995 (September) |
| 1 | Betula - Cohort 2 - T2 |
|
|
1998 (September) | 2001 (March) |
Betula - Cohort 3
The population consists of randomly selected individuals aged from 40 to 85 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
40
- Maximum age
-
84
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 40, 45, 50, 55, 60, 65, 70, 75, 80 and 85 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 963
- Supplementary Information about selection criteria
-
T1: 963 participants
T2: 826 participants
T3: 689 participants
T4: 440 participants
T5: 259 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 3 - T1 |
|
|
1993 (September) | 1995 (September) |
| 1 | Betula - Cohort 3 - T2 |
|
|
1998 (September) | 2001 (March) |
| 2 | Betula - Cohort 3 - T3 |
|
|
2003 (September) | 2005 (November) |
| 3 | Betula - Cohort 3 - T4 |
|
|
2008 (October) | 2010 (March) |
| 4 | Betula - Cohort 3 - T5 |
|
|
2013 (September) | 2014 (July) |
Betula - Cohort 4
The population consists of randomly selected individuals aged from 35 to 90 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
35
- Maximum age
-
90
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 and 90 years. In each age group, roughly 50 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 553
- Supplementary Information about selection criteria
-
T1: 553 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 4 - T1 |
|
|
1998 (September) | 2001 (March) |
Betula - Cohort 5
The population consists of randomly selected individuals aged from 35 to 95 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
35
- Maximum age
-
95
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90 and 95 years. In each age group, roughly 45 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population
Sample Size
- Number of Participants
- 558
- Supplementary Information about selection criteria
-
T1: 558 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 5 - T1 |
|
|
2003 (September) | 2005 (November) |
Betula - Cohort 6
The population consists of randomly selected individuals aged from 25 to 80 years, from the municipality of Umeå, northern Sweden. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Selection Criteria
- Minimum age
-
25
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 360 randomly selected individuals were recruited from the Umeå municipality in the age groups 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 30 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 357
- Supplementary Information about selection criteria
-
T1: 357 participants
T2: 66 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Betula - Cohort 6 - T1 |
|
|
2008 (October) | 2010 (March) |
| 1 | Betula - Cohort 6 - T2 |
|
|
2013 (September) | 2014 (July) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2021-07-26T16:33:32.517