Betula Study
- The main objectives of Betula study are:
- To study how memory functions change during adult life and old age;
- To identify risk factors for dementia;
- To identify early preclinical signs of dementia.
Overview
- Acronym
- Betula
- Website
- Betula
- Investigators
-
-
Prof. Lars Nyberg
Umeå universitet
-
Dr. Anna Sundström
Umeå universitet
-
Dr. Michael Rönnlund
Umeå universitet
-
Pr. Rolf Adolfsson
Umeå universitet
-
Prof. Lars Nyberg
- Contacts
-
-
Mikael Stiernstedt
Umeå universitet
-
Mikael Stiernstedt
General Design
- Study design
- Cohort
- Start Year
- 1988
- End Year
- 2014
- General Information on Follow Up (profile, frequency)
- The participants were assessed at 6 different time points every 5 years: in 1988-1990, 1993-1995, 1998-2000, 2003-2005, 2008-2010 and 2013-2014.
- Recruitment Target
-
- Individuals
- Number of Participants
- 4,425
- Number of Participants with Biological Samples
- 4,300
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
1. Zimbardo Time Perspective Inventory Based on: (ZTPI) Zimbardo o. Boyds skala (Zimbardo, P., and Boyd, J. N. (1999). Used in Betula: Carelli, M. G., Wiberg, B., & Wiberg, M. (2011). Development and Construct Validation of the Swedish Zimbardo Time Perspective Inventory. European Journal of Psychological Assessment, 27(4), 220–227. https://doi.org/10.1027/1015-5759/a000076
2. Patient Health Questionnaire-9 Based on: Kroenke, K., Spitzer, RL. & Willimas, JB. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x Used in Betula: translated version.
3. Perceived Stress Questionnaire Based on: Levenstein S, Prantera C, Varvo V, Scribano ML, Berto E, Luzi C, Andreoli A. Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. J Psychosom Res 1993;37:19–32. https://doi.org/10.1016/0022-3999(93)90120-5.
Bergdahl, J., and Bergdahl, M. (2002). Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. Stress Health 18, 235–241. doi: 10.1002/smi.946 Used in Betula: translated version.
4. Seasonal Pattern Assessment Questionnaire Based on: Rosenthal, NE., Sack, DA., Gillin, JC., Lewy AJ., Goodwin, FK., Davenport, Y., Mueller, PS., Newsome, DA. & Wehr, TA. (1984). Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry, 41(1), 72-80. https://doi.org/10.1001/archpsyc.1984.01790120076010 Used in Betula: translated version
Marker Paper
Nilsson L-G, Adolfsson R, Bäckman L, de Frias C, Molander B, Nyberg L. Betula: A Prospective Cohort Study on Memory, Health and Aging. Aging, Neuropsychology and Cognition,2004; 11 (2-3), 134-148.
Supplementary Information
Nilsson, L.-Gör., Bäckman, L., Erngrund, K., et al. The Betula Prospective Cohort Study: Memory, Health, and Aging. Aging, Neuropsychology, and Cognition,1997; 4(1), 1–32.
Timeline
Populations
Selection Criteria
- Minimum age
-
35
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. The study began with including 1000 randomly selected individuals from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 1,000
- Supplementary Information
-
T1: 1000 participants
T2: 875 participants
T3: 729 participants
T4: 591 participants
T5: 403 participants
T6: 249 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 1 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
1988 (November) | 1991 (April) |
| 1 | Betula - Cohort 1 - T2 | At Testwave 2 (T2), participants from Sample 1 (S1) returned for testing and those ... |
1993 (September) | 1995 (September) |
| 2 | Betula - Cohort 1 - T3 | At Testwave 3 (T3) participants from Samples S1, S2 and S3 returned for testing ... |
1998 (September) | 2001 (March) |
| 3 | Betula - Cohort 1 - T4 | At Testwave 4 (T4) participants from samples S1 and S3 returned for testing while ... |
2003 (September) | 2005 (November) |
| 4 | Betula - Cohort 1 - T5 | At T5 participants from S1 and S3 returned for testing. At this test wave, another ... |
2008 (October) | 2010 (March) |
| 5 | Betula - Cohort 1 - T6 | At Testwave 6 (T6) participants from S1, S3, and S6 returned for testing. ... |
2013 (September) | 2014 (July) |
Selection Criteria
- Minimum age
-
35
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 994
- Supplementary Information
-
T1: 994 participants
T2: 681 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 2 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
1993 (September) | 1995 (September) |
| 1 | Betula - Cohort 2 - T2 | At each data collection time point, participants came to the Betula lab twice. The ... |
1998 (September) | 2001 (March) |
Selection Criteria
- Minimum age
-
40
- Maximum age
-
84
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 1000 randomly selected individuals were recruited from the Umeå municipality in the age groups 40, 45, 50, 55, 60, 65, 70, 75, 80 and 85 years. In each age group, roughly 100 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 963
- Supplementary Information
-
T1: 963 participants
T2: 826 participants
T3: 689 participants
T4: 440 participants
T5: 259 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 3 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
1993 (September) | 1995 (September) |
| 1 | Betula - Cohort 3 - T2 | At each data collection time point, participants came to the Betula lab twice. The ... |
1998 (September) | 2001 (March) |
| 2 | Betula - Cohort 3 - T3 | At each data collection time point, participants came to the Betula lab twice. The ... |
2003 (September) | 2005 (November) |
| 3 | Betula - Cohort 3 - T4 | At each data collection time point, participants came to the Betula lab twice. The ... |
2008 (October) | 2010 (March) |
| 4 | Betula - Cohort 3 - T5 | At each data collection time point, participants came to the Betula lab twice. The ... |
2013 (September) | 2014 (July) |
Selection Criteria
- Minimum age
-
35
- Maximum age
-
90
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 and 90 years. In each age group, roughly 50 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 553
- Supplementary Information
- T1: 553 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 4 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
1998 (September) | 2001 (March) |
Selection Criteria
- Minimum age
-
35
- Maximum age
-
95
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 600 randomly selected individuals were recruited from the Umeå municipality in the age groups 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90 and 95 years. In each age group, roughly 45 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population
Sample Size
- Number of Participants
- 558
- Supplementary Information
- T1: 558 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 5 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
2003 (September) | 2005 (November) |
Selection Criteria
- Minimum age
-
25
- Maximum age
-
80
- Countries
-
- Sweden
- Territory
- Municipality of Umeå, Västerbotten
- Other Criteria
- When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
- Recruitment of participants was done by randomly obtaining names from the population registry in Umeå, Sweden. At inclusion, close to 360 randomly selected individuals were recruited from the Umeå municipality in the age groups 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75 and 80 years. In each age group, 30 participants were selected. The gender distribution at inclusion was aimed to reflect the proportion of males and females in each age cohort of the general population.
Sample Size
- Number of Participants
- 357
- Supplementary Information
-
T1: 357 participants
T2: 66 participants
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | Betula - Cohort 6 - T1 | At each data collection time point, participants came to the Betula lab twice. The ... |
2008 (October) | 2010 (March) |
| 1 | Betula - Cohort 6 - T2 | At each data collection time point, participants came to the Betula lab twice. The ... |
2013 (September) | 2014 (July) |
Individual Studies Included
| Acronym | Name | Study design | Participants | Countries |
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Harmonization Projects Included
| Acronym | Name |
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Networks
| Acronym | Name | Studies |
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Datasets
| Name | Type | Data Collection Events | Variables |
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