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  3. Bipso

Longitudinal Study of the Bio-Psycho-Social Functioning of a Sample of Adults and Children from the CIUSSS de la Capitale-Nationale Territory According to Their Personal and Family Mental Health History

The primary objective of the study is to longitudinally characterize, in terms of bio-psycho-social functioning, the largest possible sample of patients with Major Psychiatric Disorders (MPDs) and their at-risk children in the CIUSSS-CN (Health and Social Services Centre of the Capitale-Nationale region). The secondary objectives are related to the developmental trajectory of the participants, mapped using a combination of bio-psycho-social protective and risk factors of the sample. The aims are: * To gain a more profound understanding of the prevalence of MPDs within the population that is under the responsibility of the CIUSSS-CN, and to trace the bio-psycho-social developmental trajectory of children with or without a family history of MPDs. * To understand and model the relative contribution of bio-psycho-social protective and risk factors and their interaction on the occurrence of MPDs in children once they reach the age of incidence, and to detect potential risk endophenotypes. * To identify critical periods when the intervention of protective and/or bio-psycho-social risk factors may prevent, delay or precipitate the onset of MPDs at the age of incidence. * To identify families with or without a history of MPDs in the CIUSSS de la Capitale-Nationale area who might be interested in collaborating on other research projects in our network.

Overview

Acronym
Bipso
Website
Bipso
Investigators
Dr. Pierre Marquet
CERVO Brain Research Centre, Université Laval
Dr. Marc Hébert
CERVO Brain Research Centre, Université Laval
Dr. Chantal Mérette
CERVO Brain Research Centre, Université de Laval
Dr. Martin Roy
CERVO Brain Research Centre
Contacts
Bipso

General Design

Study design
Cohort
Start - End Year
2022 -
General Information on Follow Up (profile, frequency)
After the inclusion phase, offsprings are followed up at three and six years.
Recruitment Target
  • Families
Number of Participants
416
Supplementary information about number of participants
The sample plans to include: * 150 children with a family history of MPDs (major psychiatric disorders) * 150 children without a family history of MPDs * 100 MPD parents (proband or index case) * 100 parents without MPDs * 50 MPD patients without children

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Metadata

Yes
No
Not applicable
Don't know

Timeline

Populations

Bipso - At-risk Children
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.

Selection Criteria

Minimum age
6
Maximum age
11
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
Supplementary Information
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.

Sample Size

Number of Participants
18

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - At-risk Children - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2022 (February) 2030 (February)
1 Bipso - At-risk Children - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2025 (February) 2030 (February)
2 Bipso - At-risk Children - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2028 (February) 2030 (February)
Bipso - At-risk Adolescent
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.

Selection Criteria

Minimum age
12
Maximum age
17
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

Specific Population
  • Clinic patients
Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
Supplementary Information
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.

Sample Size

Number of Participants
29

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - At-risk Adolescent - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2022 (February) 2030 (February)
1 Bipso - At-risk Adolescent - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2025 (February) 2030 (February)
2 Bipso - At-risk Adolescent - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2022 (February) 2030 (February)
Bipso - At-risk Adults
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.

Selection Criteria

Minimum age
18
Maximum age
24
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
Supplementary Information
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.

Sample Size

Number of Participants
8

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - At-risk Children - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2022 (February) 2030 (February)
1 Bipso - At-risk Children - 3-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2025 (February) 2030 (February)
2 Bipso - At-risk Children - 6-year follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2028 (February) 2030 (February)
Bipso - Control Children
The population is composed of children who biological parents have no documented history of mental illness such as schizophrenia, bipolar disorder, or major depression but who require psychiatric follow-up.

Selection Criteria

Minimum age
6
Maximum age
24
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale
Supplementary Information about selection criteria
Because of the particularities of different age groups, the assessments are broken down by age subgroup to suit each one. The age subgroups are as follows: * Children: ages 6 to 11 inclusive * Adolescents: ages 12 to 17 inclusive * Adolescents and adults: 18 to 24 inclusive

Sources of Recruitment

Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.

Sample Size

Number of Participants
150

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - Control Children - Study inclusion
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2022 (February) 2030 (February)
1 Bipso - Control Children - 3-years follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2025 (February) 2030 (February)
2 Bipso - Control Children - 6-years follow-up
  • Questionnaires
  • Administrative databases
  • Other : Academic records
2028 (February) 2030 (February)
Bipso - MPD Parents
The population is composed of parents (proband or index case) who have a primary diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders (Fourth or Fifth Edition), including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.

Selection Criteria

Minimum age
18
Maximum age
65
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

Specific Population
  • Clinic patients
Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
  • Validation of a biomarker for bipolar disorder using fibroblast cultures.
Supplementary Information
Participants are also recruited if they were previously followed perinatal clinics.

Sample Size

Number of Participants
100

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - MPD Parents - Study inclusion
  • Questionnaires
  • Administrative databases
2022 (February) 2030 (February)
Bipso - Control Parents
The population is composed of adults who have no lifetime history of psychiatric diagnoses, including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.

Selection Criteria

Minimum age
18
Maximum age
65
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale
Supplementary Information about selection criteria
The study basically enrolled the controls of index case (adult without MPD) as a family, with an average of 1.5 children in the family enrolled in the study, bringing the estimated number of controls 6-24 years old enrolled to 150 with 100 controls of index recruited.

Sources of Recruitment

General Population
  • Volunteer enrolment
Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.

Sample Size

Number of Participants
100

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - Control Parents - Study inclusion
  • Questionnaires
  • Administrative databases
2022 (February) 2030 (February)
Bipso - MPD Adults
The population is composed of adults with primary who have a primary diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders (fourth or fifth edition), including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.

Selection Criteria

Minimum age
18
Maximum age
65
Countries
  • Canada
Canadian Provinces
  • Quebec
Territory
Capitale-Nationale

Sources of Recruitment

Specific Population
  • Clinic patients
Participants from Existing Studies
  • Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
  • Validation of a biomarker for bipolar disorder using fibroblast cultures.

Sample Size

Number of Participants
11

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 Bipso - MPD Adults - Study inclusion
  • Questionnaires
  • Administrative databases
2022 (February) 2030 (February)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2026-02-20T13:56:33.374