Longitudinal Study of the Bio-Psycho-Social Functioning of a Sample of Adults and Children from the CIUSSS de la Capitale-Nationale Territory According to Their Personal and Family Mental Health History
The primary objective of the study is to longitudinally characterize, in terms of bio-psycho-social functioning, the largest possible sample of patients with Major Psychiatric Disorders (MPDs) and their at-risk children in the CIUSSS-CN (Health and Social Services Centre of the Capitale-Nationale region).
The secondary objectives are related to the developmental trajectory of the participants, mapped using a combination of bio-psycho-social protective and risk factors of the sample.
The aims are:
* To gain a more profound understanding of the prevalence of MPDs within the population that is under the responsibility of the CIUSSS-CN, and to trace the bio-psycho-social developmental trajectory of children with or without a family history of MPDs.
* To understand and model the relative contribution of bio-psycho-social protective and risk factors and their interaction on the occurrence of MPDs in children once they reach the age of incidence, and to detect potential risk endophenotypes.
* To identify critical periods when the intervention of protective and/or bio-psycho-social risk factors may prevent, delay or precipitate the onset of MPDs at the age of incidence.
* To identify families with or without a history of MPDs in the CIUSSS de la Capitale-Nationale area who might be interested in collaborating on other research projects in our network.
Overview
- Acronym
- Bipso
- Website
- Bipso
- Investigators
-
- Contacts
General Design
- Study design
- Cohort
- Start - End Year
- 2022 -
- General Information on Follow Up (profile, frequency)
-
After the inclusion phase, offsprings are followed up at three and six years.
- Recruitment Target
-
- Families
- Number of Participants
- 416
- Supplementary information about number of participants
-
The sample plans to include: * 150 children with a family history of MPDs (major psychiatric disorders) * 150 children without a family history of MPDs * 100 MPD parents (proband or index case) * 100 parents without MPDs * 50 MPD patients without children
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Metadata
Timeline
Populations
Bipso - At-risk Children
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
6
- Maximum age
-
11
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
Sources of Recruitment
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
- Supplementary Information
-
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.
Sample Size
- Number of Participants
- 18
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - At-risk Children - Study inclusion |
|
2022 (February) | 2030 (February) | |
| 1 | Bipso - At-risk Children - 3-year follow-up |
|
2025 (February) | 2030 (February) | |
| 2 | Bipso - At-risk Children - 6-year follow-up |
|
2028 (February) | 2030 (February) |
Bipso - At-risk Adolescent
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
12
- Maximum age
-
17
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
- Supplementary Information
-
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.
Sample Size
- Number of Participants
- 29
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - At-risk Adolescent - Study inclusion |
|
2022 (February) | 2030 (February) | |
| 1 | Bipso - At-risk Adolescent - 3-year follow-up |
|
2025 (February) | 2030 (February) | |
| 2 | Bipso - At-risk Adolescent - 6-year follow-up |
|
2022 (February) | 2030 (February) |
Bipso - At-risk Adults
The population is composed of offspring with at least one biological parent who has a documented history of a major psychiatric disorder such as schizophrenia, bipolar disorder, or major depression, and requires ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
18
- Maximum age
-
24
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
Sources of Recruitment
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
- Supplementary Information
-
Participants are also recruited through the Perinatal Psychiatry Clinic of the Quebec University Institute of Mental Health.
Sample Size
- Number of Participants
- 8
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - At-risk Children - Study inclusion |
|
2022 (February) | 2030 (February) | |
| 1 | Bipso - At-risk Children - 3-year follow-up |
|
2025 (February) | 2030 (February) | |
| 2 | Bipso - At-risk Children - 6-year follow-up |
|
2028 (February) | 2030 (February) |
Bipso - Control Children
The population is composed of children who biological parents have no documented history of mental illness such as schizophrenia, bipolar disorder, or major depression but who require psychiatric follow-up.
Selection Criteria
- Minimum age
-
6
- Maximum age
-
24
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
- Supplementary Information about selection criteria
-
Because of the particularities of different age groups, the assessments are broken down by age subgroup to suit each one. The age subgroups are as follows: * Children: ages 6 to 11 inclusive * Adolescents: ages 12 to 17 inclusive * Adolescents and adults: 18 to 24 inclusive
Sources of Recruitment
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
Sample Size
- Number of Participants
- 150
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - Control Children - Study inclusion |
|
2022 (February) | 2030 (February) | |
| 1 | Bipso - Control Children - 3-years follow-up |
|
2025 (February) | 2030 (February) | |
| 2 | Bipso - Control Children - 6-years follow-up |
|
2028 (February) | 2030 (February) |
Bipso - MPD Parents
The population is composed of parents (proband or index case) who have a primary diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders (Fourth or Fifth Edition), including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
18
- Maximum age
-
65
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
- Validation of a biomarker for bipolar disorder using fibroblast cultures.
- Supplementary Information
-
Participants are also recruited if they were previously followed perinatal clinics.
Sample Size
- Number of Participants
- 100
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - MPD Parents - Study inclusion |
|
2022 (February) | 2030 (February) |
Bipso - Control Parents
The population is composed of adults who have no lifetime history of psychiatric diagnoses, including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
18
- Maximum age
-
65
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
- Supplementary Information about selection criteria
-
The study basically enrolled the controls of index case (adult without MPD) as a family, with an average of 1.5 children in the family enrolled in the study, bringing the estimated number of controls 6-24 years old enrolled to 150 with 100 controls of index recruited.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
Sample Size
- Number of Participants
- 100
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - Control Parents - Study inclusion |
|
2022 (February) | 2030 (February) |
Bipso - MPD Adults
The population is composed of adults with primary who have a primary diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders (fourth or fifth edition), including but not limited to schizophrenia, bipolar disorder, or major depression, and who require ongoing psychiatric follow-up.
Selection Criteria
- Minimum age
-
18
- Maximum age
-
65
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Capitale-Nationale
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Participants from Existing Studies
-
- Study of abnormalities related to the development of self-consciousness as a neurodevelopmental endophenotype of risk for schizophrenia, bipolar disorder or recurrent major depression.
- Validation of a biomarker for bipolar disorder using fibroblast cultures.
Sample Size
- Number of Participants
- 11
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Bipso - MPD Adults - Study inclusion |
|
2022 (February) | 2030 (February) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2025-06-19T13:25:38.680