Canadian Mother-Child Cohort
The Canadian Mother-Child Cohort is a Canadian initiative bringing together real world data from various provinces to address a critical public health issue facing Canada and the rest of the world: the impact of prescription drug use during pregnancy on long-term health outcomes in both mother and child.
The ultimate goal is to identify serious events associated with gestational medication use in a timely manner, which allows us to take preventive measures in order to avert or minimize them.
The secondary objectives are to:
* Develop and put in place large provincial mother-child longitudinal, population-based cohorts in Canada.
* Develop standardized and harmonized tools (Common Data Models (CDM)/Definitions/Codes/Algorithms) to adequately and similarly identify pregnancy/child cohorts with longitudinal follow-ups.
* Assess use, safety and effectiveness of drug use during pregnancy and in childhood.
* Provide a surveillance system to evaluate and identify safety signals that can be used to rapidly answer queries from policy makers.
* Find cost-effective health strategies and policies improving the health of mothers, children, and the overall Canadian population.
* Develop a Canadian consortium of researchers, highly qualified personnel, and knowledge users that can continue to take an active leadership role in building an international collaborative network.
Overview
- Acronym
- CaMCCo
- Website
- CaMCCo
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1995 - 2022
- General Information on Follow Up (profile, frequency)
-
* The follow-up is continuous through billing, hospital and socio-demographic databases in each province. * Women are followed from 12 months before the beginning of pregnancy, defined as the first day of the last menstrual period, until the end of pregnancy. * The children are followed from birth up to the end of the study.
- Recruitment Target
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- Families
- Number of Participants
- No Limit
- Supplementary information about number of participants
-
In 2022, the study included approximately 4 million Canadian pregnancies and 3.15 million children.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Everyone requesting data access and doing statistical analyses are signing a confidentiality agreement form. All requests need to include at least one CaMCCO investigator to ensure harmonization of reporting. Access requests to CaMCCO for research purposes should be sent to A Bérard, and approved by the Steering Committee and provincial ethics committees.
Marker Papers
Bérard A, Sheehy O. The Quebec Pregnancy Cohort–prevalence of medication use during gestation and pregnancy outcomes. PloS one. 2014; 9(4):e9387
PUBMED 24705674Timeline
Populations
CaMCCo - Mothers
The population is composed of pregnant women from the general population between 15 and 45 years of age from one of the participating provinces.
Selection Criteria
- Sex
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Women only
- Minimum age
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15
- Maximum age
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45
- Pregnant Women
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- First trimester
- Second trimester
- Third trimester
- Countries
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- Canada
- Canadian Provinces
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- Alberta
- British Columbia
- Manitoba
- Ontario
- Quebec
- Saskatchewan
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Pregnant women were recruited from the governmental databases.
Sample Size
- Number of Participants
- No Limit
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CaMCCo - Mothers - Data capture |
|
1995 | 2022 |
CaMCCo - Children
The population is composed of the newborns of mothers recruited for the CAMCCO study.
Selection Criteria
- Newborns
- Countries
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- Canada
- Canadian Provinces
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- Alberta
- British Columbia
- Manitoba
- Ontario
- Quebec
- Saskatchewan
- Other Criteria
- Singleton, and multiples liveborn babies of the women also included in the study.
- Supplementary Information about selection criteria
-
The status of the newborn is obtained via the births and deaths database or by linking the mother-child hospital patient charts.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Newborns of participating mother were recruited from the governmental database.
Sample Size
- Number of Participants
- No Limit
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CaMCCo - Children - Data capture |
|
1995 | 2022 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T12:22:18.668