Canadian COVID-19 Emergency Department Rapid Response Network: Real-World Vaccine Effectiveness and Duration of Protection in Special Populations
The objective of this registry is to leverage established infrastructure to create a national vaccine evaluation platform in partnership with provincial Public Health Partners.
The specific objectives are to evaluate:
1. The effectiveness of COVID-19 vaccines for preventing severe COVID-19 in priority groups, including in racialized and Indigenous communities, individuals of lower socioeconomic status (SES), those with active comorbidity (e.g., active cancer), at the extremes of ages, in pregnant and breastfeeding women, and in otherwise marginalized groups (e.g., homeless);
2. The effectiveness of COVID-19 vaccines in preventing severe disease, hospitalization and mortality, as delivered in the real-world, including single doses of vaccines authorized as two-dose series, delayed boosters, and receipt of vaccines from different manufacturers; and
3. The duration of vaccine protection from symptomatic COVID-19 in the general population and in specific groups (e.g., elderly with immune senescence), by vaccine type, for single doses of vaccines authorized as two-dose series, and in individuals receiving a delayed booster.
Overview
- Acronym
- CCEDRRN-VE
- Website
- CCEDRRN-VE
- Investigators
-
- Contacts
-
General Design
- Study design
- Registry
- Start - End Year
- 2021 - 2022
- General Information on Follow Up (profile, frequency)
-
Participants are followed up at 60 days, and at 6 and 12 months after visit to the emergency department.
- Recruitment Target
-
- Individuals
- Number of Participants
- 80,000
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Hohl CM, Rosychuk RJ, McRae AD et al. Canadian COVID-19 Emergency Department Rapid Response Network investigators and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study. CMAJ Open.E261-E270.
PUBMED 33731427Timeline
Populations
CCEDRRN-VE - COVID-19 positive
The population is composed of patients who receive care for symptomatic and severe COVID-19, and were inadequately evaluated in or excluded from phase 3 vaccine effectiveness (VE) trials in any of the 50 participating emergency departments (EDs) across 8 provinces ( Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario, Quebec, Saskatchewan).
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- New Brunswick
- Nova Scotia
- Ontario
- Quebec
- Saskatchewan
- Health Status
-
- COVID-19 positive patients with active co-morbidities, with cancer including those receiving treatments for their malignancies, or with autoimmunity including those receiving treatments that may alter their immune response
- Other Criteria
-
Inclusion:
Racialized communities
Indigenous communities
Individuals of lower socioeconomic status, homeless
Individuals with primary or secondary immune defects
Individuals with substance use disorder
Individuals at the extremes of ages
Sources of Recruitment
- Specific Population
-
- Other specific population : Patients who visited participating emergency departments
- Supplementary Information
-
Participants were contacted for participation if they visited any of the 50 participating emergency departments and were tested for COVID -19.
Sample Size
- Number of Participants
- 80,000
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 1 | CCEDRRN-VE - COVID-19 positive - 60 days |
|
2021 (July) | 2021 (July) | |
| 2 | CCEDRRN-VE - COVID-19 positive - 6 months |
|
2021 (November) | 2021 (November) | |
| 3 | CCEDRRN-VE - COVID-19 positive - 12 months |
|
2022 (May) | 2022 (May) |
CCEDRRN-VE - COVID-19 negative
The population is composed of patients who tested negative for COVID-19 in any of the 50 participating emergency departments (EDs) across 8 provinces ( Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario, Quebec, Saskatchewan).
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- New Brunswick
- Nova Scotia
- Ontario
- Quebec
- Saskatchewan
- Health Status
-
- Tested negative for COVID-19 with active co-morbidities, with cancer including those receiving treatments for their malignancies, or with autoimmunity including those receiving treatments that may alter their immune response
- Other Criteria
-
Inclusion:
Racialized communities
Indigenous communities
Individuals of lower socioeconomic status, homeless
Individuals with primary or secondary immune defects
Individuals with substance use disorder
Individuals at the extremes of ages
Sources of Recruitment
- Specific Population
-
- Other specific population : Patients who visited a participating Emergency Department
- Supplementary Information
-
Participants were contacted for participation if they visited any of the 50 participating emergency departments and were tested for COVID -19.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 1 | CCEDRRN-VE - COVID-19 negative - 60 days |
|
2021 (July) | 2021 (July) | |
| 2 | CCEDRRN-VE - COVID-19 negative - 6 months |
|
2021 (November) | 2021 (November) | |
| 3 | CCEDRRN-VE - COVID-19 negative - 12 months |
|
2022 (May) | 2022 (May) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T06:28:34.816