Cognitive Function and Ageing Study
The aims of the CFAS study are:
- To find out how common dementia and associated conditions are in England and Wales and also, how many new cases of dementia develop each year in England and Wales;
- To find out if dementia varies around the country;
- To describe the service needs of dementia sufferers and the degree of disability suffered;
- To find out which factors increase the risk of someone developing dementia;
- To investigate the different diseases that cause dementia and how quickly dementia progresses.
Overview
- Acronym
- CFAS
- Website
- CFAS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1989 -
- General Information on Follow Up (profile, frequency)
-
The follow-up has been determined by funding and the design of associated bolt-on studies. CFAS is a group of studies with various follow-up intervals – please see the specific sections below for more detail.
- Recruitment Target
-
- Individuals
- Number of Participants
- 25,504
- Number of Participants with Biological Samples
- 2,670
- Supplementary information about number of participants
-
Additional biological samples will be collected for CFAS II and CFAS Wales.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Brayne C, McCracken C, Matthews FE; Medical Research Council Coginitive Function and Ageing Study (CFAS). Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS). International Journal of Epidemiology, 2006; 35(5): 1140-5.
PUBMED 16980700Timeline
Populations
The population is composed of all those aged 65 years and older on the index date of recruitment, living in the community, including institutions.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United Kingdom
- Territory
-
Liverpool, Cambridgeshire, Gwynedd, Newcastle, Nottingham and Oxford
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Family Health Service Authority (FHSA) lists were used as the sampling frame.
Sample Size
- Number of Participants
- 13,004
- Number of Participants with Biological Samples
- 2,670
- Supplementary information about number of participants
-
Baseline: 13 004 participants
Year 1 follow-up: 920 participants
Year 2 follow-up: 7175 participants
Year 3 follow-up: 590 participants
Year 5 follow-up: 1733 participants
Year 8 follow-up: 389 participants
Year 10 follow-up: 3145 participants
Year 12 follow-up: 188 participants
Year 14 follow-up: 131 participants
Year 16 follow-up: 95 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CFAS I - Baseline |
|
1989 | 1993 | |
| 1 | CFAS I - Year 1 follow-up |
|
1990 | 1994 | |
| 2 | CFAS I - Year 2 follow-up |
|
1991 | 1995 | |
| 3 | CFAS I - Year 3 follow-up |
|
1992 | 1996 | |
| 4 | CFAS I - Year 5 follow-up |
|
|
1994 | 1998 |
| 5 | CFAS I - Year 8 follow-up |
|
1997 | 2001 | |
| 6 | CFAS I - Year 10 follow-up |
|
1999 | 2003 | |
| 7 | CFAS I - Year 12 follow-up |
|
2001 | 2005 | |
| 8 | CFAS I - Year 14 follow-up |
|
2003 | 2007 | |
| 9 | CFAS I - Year 16 follow-up |
|
2005 | 2008 |
The population is composed of all those aged 65 years and older on the index date of recruitment, living in the community, including institutions.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United Kingdom
- Territory
-
Newcastle upon Tyne, Nottingham and Cambridgeshire
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Primary Care Trust (PCT) lists were used as the sampling frame. Any individuals previously included in the CFAS study was available for the new cohort study as this is a complete re-enumeration of the population and the last follow up was completed in 2008.
Sample Size
- Number of Participants
- 7,500
- Supplementary information about number of participants
-
The number above is the target number of participants.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CFAS II - Baseline |
|
2008 | 2011 | |
| 1 | CFAS II - Year 2 follow-up |
|
2011 | 2013 |
The population is composed of all those aged 65 years and older on the index date of recruitment, living in the community, including institutions.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United Kingdom
- Territory
-
Wales (Gwynedd and Swansea)
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Primary Care Trust (PCT) lists were used as the sampling frame.
Sample Size
- Number of Participants
- 5,000
- Supplementary information about number of participants
-
The number above is the target number of participants.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CFAS Wales - Baseline |
|
2010 | 2012 | |
| 1 | CFAS Wales - Year 2 follow-up |
|
2013 | 2016 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|