CHILD Cohort Study

Overview

Acronym
CHILD
Website
CHILD
Investigators
  • Dr. Padmaja Subbarao

    The Hospital for Sick Children, University of Toronto

  • Dr. Sonia Anand

    Mcmaster University

  • Dr. Meghan Azad

    University of Manitoba

  • Dr. Jeff Brook

    Universit of Toronto

  • Dr. Michael Kobor

    University of British Columbia

  • Dr. Wendy Lou

    University of Toronto

  • Dr. Piush Mandhane

    University of Alberta

  • Dr. Stuart Turvey

    BC Children's Hospital

  • Dr. Theo Moraes

    The Hospital for Sick Children

  • Dr. Elinor Simons

    University of Manitoba

Contacts
  • Dr. Padmaja Subbarao

    The Hospital for Sick Children, University of Toronto

  • Aimée Dubeau

    CHILD National Coordinating Centre

General Design

Study design
Cohort
Start Year
2008
General Information on Follow Up (profile, frequency)
Measures such as questionnaires, tests and samples were taken from mothers, fathers and children during pregnancy at recruitment (second or third trimester) and 36 weeks, at birth, and 3 months, 6 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 8 years postpartum.
Recruitment Target
  • Families
Number of Participants
9,875
Number of Participants with Biological Samples
9,464
Supplementary information about number of participants
Mothers: 3579 participants
Fathers: 2841 participants
Children: 3455 participants

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Sector of research

Possible Access to Data Possible Access to Biosamples
Investigators from the public sector
Investigators from the private sector
Investigators from not-for-profit organization

If an industry partner or private sector researcher are interested in working with the CHILD Cohort study, the study takes a collaborative research approach whereas the industry partner or private sector researcher is linked up with a CHILD Cohort Study Executive or Advisory Board member.

Transfer

Possible Access to Data Possible Access to Biosamples
Can leave the study facility
Can leave the country

All Investigators must apply to access CHILD data and samples, and sign a Materials and Information Transfer Agreement, which includes the conditions for access.

Cost

Possible Access to Data Not yet defined
Possible Access to Biosamples Fixed Cost

Cost reduction for co-analyses

Possible Access to Data
Possible Access to Biosamples

larger sample numbers allow better pricing from analysis labs

Marker Paper

Subbarao P, et al. 2015. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 70(10): 998-1000.

PUBMED 26069286

Timeline

Populations

CHILD - Mothers

Selection Criteria

Gender
Women only
Minimum age
18
Pregnant Women
  • Second trimester
  • Third trimester
Countries
  • Canada
Territory
British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)
Other Criteria
Second or third trimester of pregnancy
Supplementary Information
Approximately 25% non-Caucasian families

Sources of Recruitment

General Population
  • Volunteer enrolment
Specific Population
  • Clinic patients
Supplementary Information
Parents were recruited at routine antenatal obstetrical ultrasound visits, person to person referrals, social media advertising, at kiosks at community events, malls and baby shows, and in health care locations.

Sample Size

Number of Participants
3,579
Number of Participants with Biological Samples
3,487
Supplementary Information
82 children failed inclusion criteria or met exclusion criteria at birth resulting in 3542 eligible mothers for follow-up.

Data Collection Events

# Name Description Start End
0 CHILD - Mothers - 18 weeks gestation 2008 (January) 2012 (December)
1 CHILD - Mothers - 36 weeks gestation 2008 (May) 2013 (April)
2 CHILD - Mothers - Birth 2008 (May) 2013 (May)
3 CHILD - Mothers - 3 months postpartum 2008 (August) 2013 (August)
4 CHILD - Mothers - 6 months postpartum 2008 (November) 2013 (November)
5 CHILD - Mothers - 1 year postpartum 2009 (May) 2014 (May)
6 CHILD - Mothers - 1.5 years postpartum 2009 (November) 2014 (November)
7 CHILD - Mothers - 2 years postpartum 2010 (May) 2015 (May)
8 CHILD - Mothers - 2.5 years postpartum 2010 (November) 2015 (November)
9 CHILD - Mothers - 3 years postpartum 2011 (May) 2016 (May)
10 CHILD - Mothers - 4 years postpartum 2012 (May) 2017 (May)
11 CHILD - Mothers - 5 years postpartum 2013 (May) 2018 (May)
12 CHILD - Mothers - 8 years postpartum 2018 (August) 2020 (December)
CHILD - Children

Selection Criteria

Newborns
Countries
  • Canada
Territory
British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)
Health Status
  • Apparently healthy children
Other Criteria
Premature, in vitro and children that were expected to spend less than 80% of their time in the primary home or if there was any expectation to move away from a recruitment center within 1 year were excluded. Children with major congenital abnormalities or respiratory distress syndrome, or children of multiple births were excluded as well.

Sources of Recruitment

Specific Population
  • Other specific population : Children of mothers who were participating in the study when they were born.

Sample Size

Number of Participants
3,455
Number of Participants with Biological Samples
3,417
Supplementary Information
The number of participants with biological samples varies depending on the nature of sample and time point for collection (range 2000-3300).

Data Collection Events

# Name Description Start End
0 CHILD - Children - Birth 2008 (May) 2012 (May)
1 CHILD - Children - 3 months postpartum 2008 (August) 2013 (August)
2 CHILD - Children - 6 months postpartum 2008 (November) 2013 (November)
3 CHILD - Children - 1 year postpartum 2009 (May) 2014 (May)
4 CHILD - Children - 1.5 years postpartum 2009 (November) 2014 (November)
5 CHILD - Children - 2 years postpartum 2010 (May) 2015 (May)
6 CHILD - Children - 2.5 years postpartum 2010 (November) 2015 (November)
7 CHILD - Children - 3 years postpartum 2011 (May) 2016 (May)
8 CHILD - Children - 4 years postpartum 2012 (May) 2017 (May)
9 CHILD - Children - 5 years postpartum 2013 (May) 2018 (May)
10 CHILD - Children - 8 years postpartum 2018 (August) 2020 (December)
CHILD - Fathers

Selection Criteria

Gender
Men only
Countries
  • Canada
Territory
British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)

Sources of Recruitment

Specific Population
  • Other specific population : Partners of the women and fathers of the children who were recruited to participate in the CHILD study.
Supplementary Information
Some fathers participated, however, their participation was not a mandatory requirement. Fathers were eligible to join the study at any time during follow-up.
Parents were recruited at routine antenatal obstetrical ultrasound visits, person to person referrals, social media advertising, at kiosks at community events, malls and baby shows, and in health care locations.

Sample Size

Number of Participants
2,841
Number of Participants with Biological Samples
2,560

Data Collection Events

# Name Description Start End
0 CHILD - Fathers - 18 weeks gestation 2008 (January) 2012 (December)
1 CHILD - Fathers - 1 year postpartum 2009 (May) 2014 (May)
2 CHILD - Fathers - 5 years postpartum 2013 (May) 2018 (May)
3 CHILD - Fathers - 8 years postpartum 2018 (August) 2020 (December)

Individual Studies Included

Acronym Name Study design Participants Countries

Harmonization Projects Included

Acronym Name

Networks

Acronym Name Studies

Datasets

Name Type Data Collection Events Variables
Last Update: 2021-09-02 21:11