CHILD Cohort Study
The Canadian Healthy Infant Longitudinal Development Study (CHILD) is designed to address gaps in understanding complex gene-environment interactions during pregnancy and early childhood and provides a platform for study of the development of atopic diseases including asthma, and other non-communicable diseases with early life origins.
Overview
- Acronym
- CHILD
- Website
- CHILD
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2008 -
- General Information on Follow Up (profile, frequency)
-
Measures such as questionnaires, tests and samples were taken from mothers, fathers and children during pregnancy at recruitment (second or third trimester) and 36 weeks, at birth, and 3 months, 6 months, 1 year, 1.5 years, 2 years, 2.5 years, 3 years, 4 years, 5 years and 8 years postpartum.
- Recruitment Target
-
- Families
- Number of Participants
- 9,875
- Number of Participants with Biological Samples
- 9,464
- Supplementary information about number of participants
-
Mothers: 3579 participants
Fathers: 2841 participants
Children: 3455 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: CHILD National Coordinating Centre (McMaster University)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
If an industry partner or private sector researcher are interested in working with the CHILD Cohort study, the study takes a collaborative research approach whereas the industry partner or private sector researcher is linked up with a CHILD Cohort Study Executive or Advisory Board member.
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
All Investigators must apply to access CHILD data and samples, and sign a Materials and Information Transfer Agreement, which includes the conditions for access.
Cost
| Possible Access to Data | Not yet defined |
| Possible Access to Biosamples | Fixed Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
larger sample numbers allow better pricing from analysis labs
Marker Papers
Subbarao P, et al. 2015. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 70(10): 998-1000.
PUBMED 26069286Timeline
Populations
CHILD - Mothers
The population is composed of women aged 18 years and older, in their second or third trimester of pregnancy, and living in four communities across Canada.
Selection Criteria
- Gender
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- Second trimester
- Third trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Ontario
- Territory
- British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)
- Other Criteria
- Second or third trimester of pregnancy
- Supplementary Information about selection criteria
-
Approximately 25% non-Caucasian families
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Parents were recruited at routine antenatal obstetrical ultrasound visits, person to person referrals, social media advertising, at kiosks at community events, malls and baby shows, and in health care locations.
Sample Size
- Number of Participants
- 3,579
- Number of Participants with Biological Samples
- 3,487
- Supplementary Information about selection criteria
-
82 children failed inclusion criteria or met exclusion criteria at birth resulting in 3542 eligible mothers for follow-up.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CHILD - Mothers - 18 weeks gestation |
|
|
2008 (January) | 2012 (December) |
| 1 | CHILD - Mothers - 36 weeks gestation |
|
2008 (May) | 2013 (April) | |
| 2 | CHILD - Mothers - Birth |
|
2008 (May) | 2013 (May) | |
| 3 | CHILD - Mothers - 3 months postpartum |
|
|
2008 (August) | 2013 (August) |
| 4 | CHILD - Mothers - 6 months postpartum |
|
2008 (November) | 2013 (November) | |
| 5 | CHILD - Mothers - 1 year postpartum |
|
|
2009 (May) | 2014 (May) |
| 6 | CHILD - Mothers - 1.5 years postpartum |
|
2009 (November) | 2014 (November) | |
| 7 | CHILD - Mothers - 2 years postpartum |
|
2010 (May) | 2015 (May) | |
| 8 | CHILD - Mothers - 2.5 years postpartum |
|
2010 (November) | 2015 (November) | |
| 9 | CHILD - Mothers - 3 years postpartum |
|
2011 (May) | 2016 (May) | |
| 10 | CHILD - Mothers - 4 years postpartum |
|
2012 (May) | 2017 (May) | |
| 11 | CHILD - Mothers - 5 years postpartum |
|
2013 (May) | 2018 (May) | |
| 12 | CHILD - Mothers - 8 years postpartum |
|
|
2018 (August) | 2020 (December) |
CHILD - Children
The population is composed of the children of the women already included in the study, born at or after 35 weeks at a designated recruitment center participating hospital.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Ontario
- Territory
- British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)
- Health Status
-
- Apparently healthy children
- Other Criteria
- Premature, in vitro and children that were expected to spend less than 80% of their time in the primary home or if there was any expectation to move away from a recruitment center within 1 year were excluded. Children with major congenital abnormalities or respiratory distress syndrome, or children of multiple births were excluded as well.
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of mothers who were participating in the study when they were born.
Sample Size
- Number of Participants
- 3,455
- Number of Participants with Biological Samples
- 3,417
- Supplementary Information about selection criteria
-
The number of participants with biological samples varies depending on the nature of sample and time point for collection (range 2000-3300).
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CHILD - Children - Birth |
|
|
2008 (May) | 2012 (May) |
| 1 | CHILD - Children - 3 months postpartum |
|
|
2008 (August) | 2013 (August) |
| 2 | CHILD - Children - 6 months postpartum |
|
2008 (November) | 2013 (November) | |
| 3 | CHILD - Children - 1 year postpartum |
|
|
2009 (May) | 2014 (May) |
| 4 | CHILD - Children - 1.5 years postpartum |
|
|
2009 (November) | 2014 (November) |
| 5 | CHILD - Children - 2 years postpartum |
|
2010 (May) | 2015 (May) | |
| 6 | CHILD - Children - 2.5 years postpartum |
|
2010 (November) | 2015 (November) | |
| 7 | CHILD - Children - 3 years postpartum |
|
|
2011 (May) | 2016 (May) |
| 8 | CHILD - Children - 4 years postpartum |
|
2012 (May) | 2017 (May) | |
| 9 | CHILD - Children - 5 years postpartum |
|
|
2013 (May) | 2018 (May) |
| 10 | CHILD - Children - 8 years postpartum |
|
|
2018 (August) | 2020 (December) |
CHILD - Fathers
The population is composed of the fathers of the children to be born into the study.
Selection Criteria
- Gender
-
Men only
- Countries
-
- Canada
- Canadian Provinces
-
- Alberta
- British Columbia
- Manitoba
- Ontario
- Territory
- British Columbia (Vancouver), Alberta (Edmonton), Manitoba (Winnipeg, Morden, Winkler), Ontario (Toronto)
Sources of Recruitment
- Specific Population
-
- Other specific population : Partners of the women and fathers of the children who were recruited to participate in the CHILD study.
- Supplementary Information
-
Some fathers participated, however, their participation was not a mandatory requirement. Fathers were eligible to join the study at any time during follow-up.
Parents were recruited at routine antenatal obstetrical ultrasound visits, person to person referrals, social media advertising, at kiosks at community events, malls and baby shows, and in health care locations.
Sample Size
- Number of Participants
- 2,841
- Number of Participants with Biological Samples
- 2,560
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | CHILD - Fathers - 18 weeks gestation |
|
|
2008 (January) | 2012 (December) |
| 1 | CHILD - Fathers - 1 year postpartum |
|
|
2009 (May) | 2014 (May) |
| 2 | CHILD - Fathers - 5 years postpartum |
|
2013 (May) | 2018 (May) | |
| 3 | CHILD - Fathers - 8 years postpartum |
|
|
2018 (August) | 2020 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-07-15T12:48:59.692