Children and COVID-19: seroprevalence study
Overview
- Acronym
- EnCORE
- Website
- EnCORE
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2020 -
- General Information on Follow Up (profile, frequency)
-
EnCORE is an open cohort and welcomed new children during the longitudinal follow-up. * Round 2 is the first follow up for the children enrolled in Round 1. * Round 3 is the second follow-up for the children that enrolled at Round 1 and the first follow-up for the children that enrolled at Round 2. * Round 4 is the first follow-up for the children enrolled in Round 3, the second follow-up for the children enrolled in Round 2 and the third follow-up for children enrolled in Round 1. * Round 5 is the first follow-up for the children enrolled in Round 4, the second follow-up for the children enrolled in Round 3, the third follow-up for children enrolled in Round 2, and the fourth follow-up for children enrolled in Round 1.
- Recruitment Target
-
- Individuals
- Number of Participants
- 6,671
- Number of Participants with Biological Samples
- 5,300
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Papers
Zinszer K, McKinnon B, Bourque N, et al. Seroprevalence of SARS-CoV-2 Antibodies Among Children in School and Day Care in Montreal, Canada. JAMA Netw Open. 2021 Nov 1;4(11):e2135975. doi: 10.1001/jamanetworkopen.2021.35975.
PUBMED 34812845Zinszer K, McKinnon B, Bourque N, et al. Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: protocol for a cohort study in Montreal, Canada. BMJ Open. 2021 Jul 8;11(7):e053245. doi: 10.1136/bmjopen-2021-053245.
PUBMED 34244288Zinszer K, Charland K, Pierce L, et al. Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montréal, Canada. Int J Infect Dis. 2023 Jun;131:119-126. doi: 10.1016/j.ijid.2023.03.036.
PUBMED 36963656Timeline
Populations
Selection Criteria
- Minimum age
-
2
- Maximum age
-
17
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Health Status
-
- Exclusion: chronic disease or other health conditions that preclude participation in the study
- Supplementary Information about Population
-
The sentinel neighbourhoods are: West Island, Hochelaga-Maisonneuve Montréal-Nord, and Plateau.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
First, sentinel neighbourhoods from Montreal were selected.
Then different school boards that operate within the selected neighbourhoods as well as with the different daycare associations were contacted.
Once school approval was received, an invitation email from the director of the school was sent to all parents and guardians of currently enrolled students. The invitation email included a short description of the project as well as a link to the study website. On the study website, students, parents, guardians, and personnel found more details about the study, describing details on how to contact the research team in addition to a video capsule that introduced the study team and study.
In addition to the letter of invitation, they also recruited participants through social media by: posting information on the school or daycare’s Facebook page when possible, Facebook ads for their study, that would be able to direct the recruitment ad to Facebook users that live in the study neighbourhoods.
Sample Size
- Number of Participants
- 4,916
- Number of Participants with Biological Samples
- 4,916
- Supplementary Information about Population
-
All participants who previously participated in the first round were invited to participate in the following rounds. For example, a participant of round 1 can also participate in round 2, 3, 4 and 5.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EnCORE - Children - Round 1 |
|
|
2020 (October) | 2021 (April) |
| 2 | EnCORE - Children - Round 2 |
|
|
2021 (May) | 2021 (September) |
| 3 | EnCORE - Children - Round 3 |
|
|
2021 (November) | 2022 (February) |
| 3 | EnCORE - Children - Round 4 |
|
|
2022 (May) | 2022 (October) |
| 4 | EnCORE - Children - Round 5 |
|
|
2023 (February) | 2023 (May) |
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
- Health Status
-
- Exclusion: chronic disease or other health conditions that preclude participation in the study
Sources of Recruitment
- Specific Population
-
- Other specific population : Personnel from the children's daycare and school
- Supplementary Information
-
Different school boards that operate within the selected neighbourhoods as well as with the different daycare associations were contacted.
Once school approval was received, an invitation email from the director of the school was sent. The invitation email included a short description of the project as well as a link to the study website. On the study website, personnel found more details about the study, describing details on how to contact the research team in addition to a video capsule that introduced the study team and study.
In addition to the letter of invitation, they also recruited participants through social media by: posting information on the school or daycare’s Facebook page when possible, Facebook ads for their study, that would be able to direct the recruitment ad to Facebook users that live in the study neighbourhoods.
All daycare and school personnel in the selected daycares and schools were eligible and were asked to participate.
Sample Size
- Number of Participants
- 382
- Number of Participants with Biological Samples
- 363
- Supplementary Information about Population
-
95% of participants provided a blood sample for serology analysis.
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EnCORE - Daycare and school personnel - Data collection |
|
|
2021 (March) | 2021 (August) |
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Participants are recruited from the children household from the study.
Sample Size
- Number of Participants
- 1,373
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EnCORE - Household - Questionnaire |
|
2021 (June) | 2021 (October) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|