Epidemiology of Dementia in Central Africa
The objectives of EPIDEMCA are:
1. To estimate and compare the prevalence of dementia and related syndromes in urban and rural areas in Central Africa (Central African Republic and Republic
of Congo), and to study the neuropsychological profiles of demented and non-demented subjects,
2. To investigate factors associated with dementia and cognitive disorders: sociodemographic, environmental factors including vascular, nutritional, lifestyle and biological factors,
3. To determine if genetic variations can modify the risk of dementia in African populations,
4. To create a biobank from native elderly Africans in order to carry out further biological, genotypic and phenotypic researches in the future.
The EPIDEMCA-FU study was then set-up to follow participants identified during EPIDEMCA during 2-3 years only in the Republic of Congo. This study aimed at:
1. Estimating mortality and its predictors among older people with dementia, with MCI and with no cognitive impairment,
2. Estimate the incidence of dementia and conversion rates between different cognitive statuses,
3. Assess a range of risk factors for dementia and cognitive impairment, particularly cardiovascular risk factors (stroke, hypertension, peripheral artery disease, obesity, …),
4. Explore the experiences of people living with dementia and their relatives, including stigma.
Overview
- Acronym
- EPIDEMCA
- Website
- EPIDEMCA
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2011 - 2015
- General Information on Follow Up (profile, frequency)
-
Participants from the Central African Republic and the Congo were first assessed in the cross-sectional two-phase surveys making up EPIDEMCA. Participants in Congo were followed-up annually between 2012 and 2015 (EPIDEMCA-FU).
- Recruitment Target
-
- Individuals
- Number of Participants
- 2,002
- Number of Participants with Biological Samples
- 1,662
- Supplementary information about number of participants
-
EPIDEMCA follow-up: 1029 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Guerchet M., Mbelesso P., Ndamba-Bandzouzi B., Pilleron, S., Desormais, I., Lacroix, P., Aboyans, V., Jésus, P., Desport, J-C, Tchalla, A.E., Marin, B., Lambert, J-C, Clément, J-P, Dartigues, J-F, Preux, P-M and for the EPIDEMCA group. Epidemiology of dementia in Central Africa (EPIDEMCA): protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo. Springerplus. 2014;3:338
PUBMED 25045613Timeline
Populations
EPIDEMCA - Nola
Participants aged 65 years old and over, from the rural area Nola in the Central African Republic.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Central African Republic
- Territory
- Nola (Sangha-Mbaéré region)
- Health Status
-
- Exclusion criteria: The presence of severe disease with short-term high risk of death.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Samples were obtained through a door-to-door knocking carried out in each district constituting the rural catchment area (Nola and villages in a 10km radius).
Sample Size
- Number of Participants
- 473
- Number of Participants with Biological Samples
- 388
- Supplementary information about number of participants
-
P1: 473 Participants
P2: 117 Participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EPIDEMCA - Nola - P1 |
|
|
2011 (November) | 2011 (December) |
| 1 | EPIDEMCA - Nola - P2 |
|
2012 (February) | 2012 (March) |
EPIDEMCA - Bangui
Participants aged 65 years old and over, from the urban area Bangui in the Central African Republic.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Central African Republic
- Territory
- Bangui
- Health Status
-
- Exclusion criteria: The presence of severe disease with short-term high risk of death.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
A random sampling proportional to the size of each main subdivision of the city was realized in order to be representative of Bangui’s diverse population.
Sample Size
- Number of Participants
- 500
- Number of Participants with Biological Samples
- 439
- Supplementary information about number of participants
-
P1: 500 Participants
P2: 115 Participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EPIDEMCA - Bangui - P1 |
|
|
2012 (January) | 2012 (February) |
| 1 | EPIDEMCA - Bangui - P2 |
|
2012 (February) | 2012 (March) |
EPIDEMCA - Gamboma
Participants aged 65 years old and over, from the rural area Gamboma in the Republic of Congo.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Congo
- Territory
- Gamboma (Plateaux region)
- Health Status
-
- Exclusion criteria: The presence of severe disease with short-term high risk of death.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Samples were obtained through a door-to-door knocking carried out in each district constituting the rural catchment area (Gamboma’s main districts).
Sample Size
- Number of Participants
- 529
- Number of Participants with Biological Samples
- 427
- Supplementary information about number of participants
-
P1: 529 Participants
P2: 193 Participants
F1: 325 Participants
F2: 200 Participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EPIDEMCA - Gamboma - P1 |
|
|
2012 (August) | 2012 (September) |
| 1 | EPIDEMCA - Gamboma - P2 |
|
2012 (November) | 2012 (December) | |
| 2 | EPIDEMCA - Gamboma - F1 |
|
2013 (July) | 2013 (August) | |
| 3 | EPIDEMCA - Gamboma - F2 |
|
2014 (July) | 2014 (August) |
EPIDEMCA - Brazzaville
Participants aged 65 years old and over, from the urban area Brazzaville in the Republic of Congo.
Selection Criteria
- Minimum age
-
65
- Countries
-
- Congo
- Territory
- Brazzaville
- Health Status
-
- Exclusion criteria: The presence of severe disease with short-term high risk of death.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
A random sampling proportional to the size of each main subdivision of the city was realized in order to be representative of Brazzaville’s diverse population.
Sample Size
- Number of Participants
- 500
- Number of Participants with Biological Samples
- 408
- Supplementary information about number of participants
-
P1: 500 Participants
P2: 131 Participants
F1: 335 Participants
F2: 276 Participants
F3: 250 Participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | EPIDEMCA - Brazzaville - P1 |
|
|
2012 (September) | 2012 (October) |
| 1 | EPIDEMCA - Brazzaville - P2 |
|
2012 (November) | 2012 (December) | |
| 2 | EPIDEMCA - Brazzaville - F1 |
|
2013 (August) | 2013 (September) | |
| 3 | EPIDEMCA - Brazzaville - F2 |
|
2014 (August) | 2014 (September) | |
| 4 | EPIDEMCA - Brazzaville - F3 |
|
2015 (August) | 2015 (September) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2020-02-05T11:07:35.296