Epidemiological Study on the Chances of Cure, Early Detection and Optimized Therapy of Chronic Diseases in the Elderly Population

    The objectives of this study are:
  • The examination and improvement of prevention, early detection and treatment of chronic diseases in older age, e.g. cardiovascular diseases, diabetes, or cancer.
  • Investigation of risk and predictive factors of chronic diseases.
  • Early detection and prognosis of chronic diseases.

Overview

Acronym
ESTHER
Website
ESTHER
Investigators
Dr. Hermann Brenner
German Cancer Research Center
Dr. Ben Schöttker
German Cancer Research Center
Dr. Bernd Holleczek
Saarland Cancer Registry
Contacts
Dr. Hermann Brenner
German Cancer Research Center
Dr. Ben Schöttker
German Cancer Research Center

General Design

Study design
Cohort
Start - End Year
2000 - 2022
General Information on Follow Up (profile, frequency)
Participants have been followed-up after 2, 5, 8, 11, 14, and 17 years so far.
Recruitment Target
  • Individuals
Number of Participants
9,940
Number of Participants with Biological Samples
9,800
Supplementary information about number of participants
Repeated blood samples were collected at the 5-, 8-, 11-, 14- and 17​-year follow-ups.
Supplementary Information
Participants were recruited by their general practitioner in the context of a general health screening examination.

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Marker Paper

Schöttker B, Haug U, Schomburg L, et al. Strong Associations of 25-Hydroxyvitamin D Levels With All-Cause, Cardiovascular, Cancer and Respiratory Disease Mortality in a Large Cohort Study. American Journal of Clinical Nutrition, 2013;97(4):782-793.

PUBMED 23446902

Timeline

Population

ESTHER population
The population consists of adults aged 50-75 years with their first residence in the federal state of Saarland, Germany. This population is a representative cohort for the older german general population.

Selection Criteria

Minimum age
50
Maximum age
75
Countries
  • Germany
Territory
Saarland (federal state)
Other Criteria
Sufficient german language skills

Sample Size

Number of Participants
9,940
Number of Participants with Biological Samples
9,800

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 ESTHER - Baseline
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
  • Urine
  • Other : Stool
2000 2002
1 ESTHER - 2-year follow-up
  • Questionnaires
  • Physical measures
  • Administrative databases
2002 2004
2 ESTHER - 5-year follow-up
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
2005 2007
3 ESTHER - 8-year follow-up
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
2008 2010
4 ESTHER - 11-year follow-up
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
2011 2013
5 ESTHER - 14-year follow-up
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Blood
2014 2016
6 ESTHER - 17-year follow-up
  • Questionnaires
  • Biosamples
  • Administrative databases
  • Blood
2017 2019

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2023-08-10T18:18:32.409