Family Atherosclerosis Monitoring in Early Life
The main objective of the Family Atherosclerosis Monitoring In earLY life study (FAMILY) is to identify the environmental, genetic, and biochemical factors important in the development of obesity, cardiovascular risk factors (dysglycemia, dyslipidemia, and hypertension), and atherosclerosis in childhood.
Overview
- Acronym
- FAMILY
- Website
- FAMILY
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2004 -
- General Information on Follow Up (profile, frequency)
-
Participants are followed-up until children are 10 years old. For the index child, questionnaires and physical measures are conducted at birth, 1, 2, 3, 5, 7 and 10 years. For mothers, after the baseline visit in pregnancy questionnaires/case report forms are completed at all follow-up visits of the children. Physical measures are conducted in mothers 3 times at visits when their child is 1, 5 and 10 years old. Partners have questionnaires/CRFs completed at baseline and at the 2, 5, 7 and 10 year time and physical measures at baseline and 5 year visit. Siblings have questionnaires/CRFs completed at baseline, 5 and 10 year visits and physical measures only at baseline and 5 year visit.
- Recruitment Target
-
- Families
- Number of Participants
- 2,552
- Number of Participants with Biological Samples
- 2,334
- Supplementary information about number of participants
-
Mothers: 857 participants
Fathers: 530 participants
Children: 901 participants
Siblings: 264 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: PI/Professor Koon Teo (PHRI, McMaster University)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
Anonymization, encryption using a secure tunnel file transfer protocol and with no attempt to re-identify the subjects. Transfer must also respect the policies of PHRI, and the protocol and informed consents of subjects.
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | N/A |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Data will be shared for purposes of a defined research project which will acknowledged the source of data and include owners of data in any publication as per a formal Access Agreement.
Marker Paper
Morrison KM, Atkinson SA, Yusuf S, Bourgeois J, McDonald S, McQueen MJ, Persadie R, Hunter B, Pogue J, Teo K; FAMILY investigators. 2009. The Family Atherosclerosis Monitoring In earLY life (FAMILY) study: rationale, design, and baseline data of a study examining the early determinants of atherosclerosis. American heart journal; 158(4): 533-9.
PUBMED 19781411Timeline
Populations
FAMILY - Mothers
The mothers population in the FAMILY study is composed of Canadian women living in the Hamilton region, in Ontario. They were recruited during their third trimester of pregnancy (gestational age of 21-39 weeks).
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- Second trimester
- Third trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton and Burlington
- Other Criteria
- Women were recruited between 21 to 39 weeks of pregnancy
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Recruitment occurred at physician offices and ultrasound clinics of 3 hospitals in Hamilton and Burlington (Hamilton Health Sciences, St Joseph's Health Center, and Joseph Brant Memorial Hospital in Burlington)
Sample Size
- Number of Participants
- 857
- Number of Participants with Biological Samples
- 857
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | FAMILY - Mothers - 21-39 weeks of pregnancy |
|
|
2004 | 2009 |
| 1 | FAMILY - Mothers - Birth |
|
2004 | 2009 | |
| 2 | FAMILY - Mothers - 1 year |
|
|
2005 | 2010 |
| 3 | FAMILY - Mothers - 2 years |
|
2006 | 2011 | |
| 4 | FAMILY - Mothers - 5 years |
|
|
2009 | 2014 |
| 5 | FAMILY - Mothers - 7-8 years |
|
2011 | 2017 | |
| 6 | FAMILY - Mothers - 10 years |
|
2014 | 2019 |
FAMILY - Fathers
The partners population in the FAMILY study is composed of Canadian living in the Hamilton region, in Ontario. They were recruited during their pregnant partners third trimester of pregnancy (gestational age of 21-39 weeks).
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton and Burlington
Sources of Recruitment
- Specific Population
-
- Other specific population : Partners of the women included in the study.
Sample Size
- Number of Participants
- 530
- Number of Participants with Biological Samples
- 530
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | FAMILY - Fathers - 21-39 weeks of pregnancy |
|
|
2004 | 2009 |
| 1 | FAMILY - Fathers - 1 year |
|
2005 | 2010 | |
| 2 | FAMILY - Fathers - 2 years |
|
2006 | 2011 | |
| 3 | FAMILY - Fathers - 5 years |
|
|
2009 | 2014 |
| 4 | FAMILY - Fathers - 7-8 years |
|
2011 | 2017 | |
| 5 | FAMILY - Fathers - 10 years |
|
2014 | 2019 |
FAMILY - Children
The children population in the FAMILY study is composed of Canadian babies born in the Hamilton region, in Ontario, between 2005 and 2009.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton and Burlington
Sources of Recruitment
- Specific Population
-
- Other specific population : Babies of the pregnant women already included in the study.
Sample Size
- Number of Participants
- 901
- Number of Participants with Biological Samples
- 683
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | FAMILY - Children - Birth |
|
|
2004 | 2009 |
| 1 | FAMILY - Children - 6 months |
|
2004 | 2010 | |
| 2 | FAMILY - Children - 1 year |
|
|
2005 | 2010 |
| 3 | FAMILY - Children - 2 years |
|
2006 | 2011 | |
| 4 | FAMILY - Children - 3 years |
|
|
2007 | 2012 |
| 5 | FAMILY - Children - 5 years |
|
|
2009 | 2014 |
| 6 | FAMILY - Children - 7-8 years |
|
|
2011 | 2017 |
| 7 | FAMILY - Children - 10 years |
|
|
2014 | 2019 |
FAMILY - Siblings
The siblings population is composed of the older full siblings of the children to be born into the study.
Selection Criteria
- Maximum age
-
18
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton and Burlington
Sources of Recruitment
- Specific Population
-
- Other specific population : Older full siblings of the children included in the study.
Sample Size
- Number of Participants
- 264
- Number of Participants with Biological Samples
- 264
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | FAMILY - Siblings - 21-39 weeks of pregnancy |
|
|
2004 | 2009 |
| 1 | FAMILY - Siblings - 5 years |
|
|
2009 | 2014 |
| 2 | FAMILY - Siblings - 7-8 years |
|
|
2011 | 2017 |
| 3 | FAMILY - Siblings - 10 years |
|
|
2014 | 2019 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T14:08:55.944