Association Between Exposure to Chlorination By-Products and the Fetal Growth Restriction
PART 1
Main objective: Evaluate the relation between maternal exposure to chlorination by-products (CBP) and the risk of delivering a small for-gestational-age neonate.
Secondary objectives:
1. To estimate trihalomethanes and haloacetic acids concentrations in tap water of each participant's residence during each trimester of pregnancy;
2. To assess individual exposure to haloacetic acids from information reported by questionnaire among participants and exposure to trihalomethanes in the water source and consumed by other sources of exposure (dermal, inhalation or ingestion) to during each trimester of pregnancy;
3. To combine for trihalomethanes (chloroform and bromodichloromethane), three routes of exposure (ingestion, dermal, inhalation) into a single measure;
4. To estimate the relative risk of fetal growth restriction associated with the exposure to total trihalomethanes, brominated trihalomethane, and total haloacetic acid for each trimester of pregnancy;
5. To estimate the relative risk of fetal growth restriction associated with the exposure to some CBP specific to trihalomethanes (chloroform and bromodichloromethane) and haloacetic acids (dichloroacetic acids and trichloroacetic acids);
PART 2
Main objective: To evaluate the in utero effects induces by CBP on the risk of fetal growth restriction, to consider the effects of new CBP and some genes and polymorphisms.
Secondary objectives:
1. To evaluate the in utero exposure to new CBP, haloacetaldehydes and haloacetonitriles on the risk of fetal growth restriction;
2.To assess individual exposure to haloactic acids through ingestion and to trihalomethanes through inhalation, dermal exposure and ingestion.
Overview
- Acronym
- FetalGrowth
- Investigators
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- Contacts
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General Design
- Study design
- Case-control
- Start - End Year
- 2006 - 2014
- Recruitment Target
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- Families
- Number of Participants
- 2,647
- Number of Participants with Biological Samples
- 1,719
- Supplementary information about number of participants
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Array A total of 1618 pairs of samples (sample from the mother and her child) 99 samples from the mother only 2 samples from the child only
- Supplementary Information
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Population-based case-control study which the sample contains all singleton live births that occurred in the region of Capitale-Nationale and the territory of Centre de santé and the territory of Centre de santé et des services sociaux du Grand Littoral (City of Lévis) between August 2006 and April 2008 .
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
The concentrations of CBP may be available.
Marker Paper
Levallois P, Gingras S, Marcoux S, Legay C, Catto C, Rodriguez M, et al. Maternal exposure to drinking-water chlorination by-products and small-for-gestational-age neonates. Epidemiology. 2012;23(2):267-76.
PUBMED 22317810Supplementary Information
The data from the questionnaires could be available, but a request to the Ethics Committee will be required.
Timeline
Population
The sample contains all singleton live births that occurred in the region of Capitale-Nationale and the territory of Centre de santé and the territory of Centre de santé et des services sociaux du Grand Littoral (City of Lévis) between August 2006 and April 2008. The selected sample represents approximately 30% of the live births during the study period. For each case of intrauterine growth retardation identified, three controls were matched. To be eligible, women must not have resided in more than 2 residences in the study area during their entire pregnancy and they must not have resided away from their residence for more than a month during their pregnancy.
Selection Criteria
- Sex
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Women only
- Minimum age
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16
- Countries
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- Canada
- Canadian Provinces
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- Quebec
- Territory
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Region of the Capitale-Nationale and territory of Centre de santé et de services sociaux du Grand Littoral (City of Lévis)
Sources of Recruitment
- General Population
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- Volunteer enrolment
- Supplementary Information
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All single live births in the territory studied and the information on the address during pregnancy were identified from the form entitled Declaration of Birth.
Sample Size
- Number of Participants
- 2,647
- Number of Participants with Biological Samples
- 1,719
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | FetalGrowth - Baseline recruitment / initial data collection |
|
|
2006 (April) | 2008 (April) |
| 1 | FetalGrowth - Follow-up |
|
|
2010 | 2012 |
Participating Studies
| Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|