Genomes for life
The main objective of GCAT is to integrate and to assess the role of genomic, epigenomic, environmental and lifestyle factors in the development of major chronic diseases (e.g. cancer, cardiovascular, respiratory, autoimmune, neurological or metabolic diseases) in Catalonia, Spain. Furthermore, GCAT aimed to assess the prevalence of epidemiological and genetic risk factors associated with the incidence of chronic diseases.
Overview
- Acronym
- GCAT
- Website
- GCAT
- Investigators
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Manuel Perucho
Germans Trias i Pujol Research Institute—IGTP
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Rafael De Cid
Germans Trias i Pujol Research Institute—IGTP
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Victor Moreno
Catalan Institute of Oncology—ICO, IDIBELL and CIBERESP
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David Torrents
Joint BSC-CRG-IRB Research Program in Computational Biolog
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Manolis Kogevinas
Barcelona Institute for Global Health—ISGlobal Barcelona
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Lauro Sumoy
Germans Trias i Pujol Research Institute—IGTP
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Ignacio Blanco
Assessment and Clinical Genetics Program HUGTiP
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Manuel Perucho
- Contacts
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Anna Carreras
Germans Trias i Pujol Research Institute—IGTP
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Anna Carreras
General Design
- Study design
- Cohort
- Start Year
- 2014
- General Information on Follow Up (profile, frequency)
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The active first follow-up through web-based questionnaire began in March 2018 and ended in December 2018. Electronic Health Register linking participants from Public Health Care System begins in January 2019 and will then be followed annually.
- Recruitment Target
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- Individuals
- Number of Participants
- 19,386
- Number of Participants with Biological Samples
- 19,386
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Paper
Obón-Santacana M, Vilardell M, Carreras A, et al. GCAT|Genomes for life: a prospective cohort study of the genomes of Catalonia. BMJ Open 2018 Mar 27;8:e018324.
PUBMED 29593016Supplementary Information
Timeline
Population
The population is composed of residents of Catalonia, Spain, aged 40 to 65 years old. Participants should not have mental or health impairment disorders and should not be planning to leave Catalonia within the 5 years post-recruitment.
Selection Criteria
- Minimum age
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40
- Maximum age
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65
- Countries
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- Spain
- Territory
- Catalonia
- Health Status
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- Participants should not have mental or health impairment disorders that impede giving written informed consent or efficient communication.
- Other Criteria
- Participants should be able to understand at least one of the two official languages (Catalan or Spanish), possess an Individual Health System Identification Card, and be current residents of Catalonia.
- Supplementary Information about Population
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Participants that plan to leave Catalonia within the next 5 years after recruitment are excluded.
Sources of Recruitment
- General Population
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- Volunteer enrolment
- Selected sample
- Supplementary Information
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Participants are mostly enrolled from blood donors invited through the Blood and Tissue Bank (BST), a public agency of the Catalan department of Health. The recruitment procedures include phone call, mail, GCAT web site or in person. Participants have to present themselves at a recruitment centre (11 permanent + additional temporary centres across Catalonia).
Sample Size
- Number of Participants
- 19,386
- Number of Participants with Biological Samples
- 19,386
Data Collection Events
| # | Name | Description | Start | End |
|---|---|---|---|---|
| 0 | GCAT - Baseline | Participants completed electronic computer-based or a paper based questionnaire ... |
2014 (March) | 2018 (March) |
| 1 | GCAT - Active Follow-Up 1 | All enrolled participants were characterized by a computer-based survey for additional ... | 2018 (March) | 2018 (December) |
Individual Studies Included
| Acronym | Name | Study design | Participants | Countries |
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Harmonization Projects Included
| Acronym | Name |
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Networks
| Acronym | Name | Studies |
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Datasets
| Name | Type | Data Collection Events | Variables |
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