Genetics of Glucose regulation in Gestation and Growth
The Gen3G study aims to increase the understanding of biological, environmental and genetic determinants of glucose regulation during pregnancy and their impact on fetal development.
Overview
- Acronym
- Gen3G
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2010 -
- General Information on Follow Up (profile, frequency)
-
Data and samples were collected at two time points during pregnancy and at delivery. The first research visit was between 5 and 16 weeks of gestation and the second visit was planned between 24 and 30 weeks. The follow-up of mothers and children 3-5 years postpartum is in process.
- Recruitment Target
-
- Families
- Number of Participants
- 1,888
- Number of Participants with Biological Samples
- 1,300
- Supplementary information about number of participants
-
Mothers: 1,034 participants
Children: 854 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
To get access to data and/or samples an official written request is required. To get the proposal form contact one of the principal investigators.
- By contacting the study representative: Prof Luigi Bouchard (Université de Sherbrooke)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
no personal identification, protected transfer of data, protocol IRB approved by receiving institution, financial support as required, DTA/MTA is also required before any transfer
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
cost depends on extent of work to prepare dataset, and/or samples handling
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Marker Papers
Guillemette L, Allard C, Lacroix M, Patenaude J, Battista MC, Doyon M, Moreau J, Ménard J, Bouchard L, Ardilouze JL, Perron P, Hivert MF. Genetics of Glucose regulation in Gestation and Growth (Gen3G): a prospective prebirth cohort of mother-child pairs in Sherbrooke, Canada. BMJ Open. 2016 Feb 3;6(2):e010031.
PUBMED 26842272Taschereau A, Doyon M,Arguin M,Allard C, Desgagné V, Cote AM, Massé É, Jacques, PE, Perron P, Hivert MF, Bouchard L. Cohort profile: The Genetics of Glucose regulation in Gestation and Growth (Gen3G) - a prospective prebirth cohort of mother–child pairs in Sherbrooke, Canada, 3- and 5-year post-partum follow
PUBMED 40122564Timeline
Populations
Gen3G - Mothers
Pregnant women, aged 18 years and older, were recruited during a visit to the blood sampling in pregnancy clinic in Sherbrooke for their first trimester clinical blood samples.
Selection Criteria
- Sex
-
Women only
- Minimum age
-
18
- Pregnant Women
-
- First trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Eastern Townships region
- Other Criteria
- Women were excluded if they: had known pre-pregnancy diabetes, took medication that influenced glucose tolerance, had glycated haemoglobin (HbA1c) ≥6.5% or 1 h glucose ≥10.3 mmol/L post-50 g GCT, as this was classified as overt diabetes based on 2008 CDA criteria.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
All women were invited to participate if they received prenatal care directly at or in a health center affiliated with the CHUS and planned delivery at the CHUS.
Sample Size
- Number of Participants
- 1,034
- Number of Participants with Biological Samples
- 696
- Supplementary information about number of participants
-
First trimester: 1034 participants
Second trimester: 898 participants
Delivery: 854 participants
3 years follow-up: 448 mother-child dyads
5 years follow-up: 521 mother-child dyads
12 years follow: 430 mother-child dyads and still ongoing
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Gen3G - Mothers - First trimester |
|
|
2010 (January) | 2013 (June) |
| 1 | Gen3G - Mothers - Second trimester |
|
|
2010 (May) | 2013 (October) |
| 2 | Gen3G - Mothers - Delivery |
|
|
2010 (August) | 2014 (January) |
| 3 | Gen3G - Mothers 3 years post delivery |
|
|
2013 (August) | 2017 (March) |
| 4 | Gen3G - Mothers 5 years post delivery |
|
|
2015 (June) | 2019 (March) |
| 5 | Gen3G - Mothers 12 years post delivery |
|
|
2021 (August) | 2025 (December) |
Gen3G - Children
The population is composed of the newborns of the women enrolled in the study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Eastern Townships region
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the women in Gen3G study
Sample Size
- Number of Participants
- 854
- Number of Participants with Biological Samples
- 604
- Supplementary information about number of participants
-
N=662 cord blood samples N= 694 placenta samples
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Gen3G - Children - Delivery |
|
|
2010 (August) | 2014 (January) |
| 1 | Gen3G - Children – 3 years post delivery |
|
|
2013 (August) | 2017 (March) |
| 2 | Gen3G - Children – 5 years post delivery |
|
|
2015 (June) | 2019 (March) |
| 3 | Gen3G - Children – 12 years post delivery |
|
|
2021 (August) | 2025 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2026-07-07T14:50:38.715