Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric exminations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 75 years-old at this time point. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric exminations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 79 years old at this time point. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric exminations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 81 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric exminations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 83 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric exminations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are collected. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 85 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer) and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 88 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer) and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory) and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, electrocardiogram (ECG), lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are at 90 years old at follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are at 92 years old at follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 95 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 97 years old at this point. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. enetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 99 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 100 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), and the Cumulative Illness Rating Scale for Geriatrics. The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), and Mini Mental State Examination. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity are taken. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 75 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 79 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 72 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 76 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 78 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 81 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 81 years old at this follow-up. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine samples are also collected. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 75 years old at this follow-up.The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 79 years old at this follow-up.The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 85 years old at this follow-up.The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 85 years old at this follow-up.The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 75 years old at this time point. Information on urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history, and onset and course of dementia information is collected from close informant. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities, and life events. Medication, self-rated health, and quality of life (ICECAP-O Quality of Life Scale) related information are collected. The psychiatric examinations were performed by psychiatrists and included ratings of psychiatric symptoms and signs with the Comprehensive Psychopathological Rating Scale, Mini-D, Montreal Cognitive Assessment, Alzheimer's Disease Assessment Scale, Clinical Dementia Rating instrument, Gottfries-Bråne-Steen Scale), perceptual speed test (PSIF), Mini Mental State Examination, other signs common in dementia, personality inventories (Cesarec Marke Personality Schedule, Eysenck Personality Questionnaire) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g., hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, brain scans (CT and MRI), lung function, measures of atherosclerosis, body composition (DEXA), Romberg balance test, grip strengths and walking capacity. Blood samples are taken and include e.g., hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum, and plasma are frozen for future analyses. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and, post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV, or DSM-5. Somatic disorders are classified according to established criteria using information from examinations, close informants, and hospital register data.

Information on urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history, and onset and course of dementia information is collected from close informant. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities, and life events. Medication, self-rated health, and quality of life (ICECAP-O Quality of Life Scale) related information are collected. The psychiatric examinations were performed by psychiatrists and included ratings of psychiatric symptoms and signs with the Comprehensive Psychopathological Rating Scale, Mini-D, Montreal Cognitive Assessment, Alzheimer's Disease Assessment Scale, Clinical Dementia Rating instrument, Gottfries-Bråne-Steen Scale), perceptual speed test (PSIF), Mini Mental State Examination, other signs common in dementia, personality inventories (Cesarec Marke Personality Schedule, Eysenck Personality Questionnaire) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g., hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, brain scans (CT and MRI), lung function, measures of atherosclerosis, body composition (DEXA), Romberg balance test, grip strengths and walking capacity. Cerebrospinal fluid samples are taken. Blood samples are taken and include e.g., hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum, and plasma are frozen for future analyses. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and, post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV, or DSM-5. Somatic disorders are classified according to established criteria using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior. Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are aged 95 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are aged 97 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are aged 99 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 100 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 101 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 102 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants are 103 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Participants at this follow-up are 104, 105, 106, 107, 108, and 109 years old. Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.

Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events. Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Mental disorders, sexuality, sleep, and suicidal behavior are assessed during the psychiatric examinations. Somatic examinations include the Cumulative Illness Rating Scale for Geriatrics and the assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer). The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia and the personality inventories (Five Factor Model, EPI). Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton). Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses. Urine and cerebrospinal fluid samples are taken. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar. Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.