Self-report questionnaires collected information about lifestyle and environmental conditions, dietary habits, quality of life, physical and sexual dysfunction, professional life, psychosocial context and burden, digital media use, medical and family history, occupational history as well as health care utilization.

Participants ungergo screening for impairment of cognitive function using the Mini-Mental State Exam (MMSE), and Clock Drawing Test (CDT).

Anthropometric measures, resting blood pressure measurements, ECG tracings as well as cardiovascular, cognitive and oral health phenotyping, skin screening, pulmonary function test, muscle tests and optical coherence tomography were performed.

Individuals identified at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited to the imaging examination including an MRI examination of the heart and the thoracic aorta and/or brain depending on the target disease.

Blood, urine, saliva as well as tooth fluid and tonsils swabs are collected. Additionally, from a random subset of study participants, skin stanza are collected of which fibroblasts are separated.

Participants are also asked for consent to match their health insurance and pension insurance data with the Hamburg study dataset.

Following the baseline examination, all participants will be mailed a questionnaire annually, which specifically asks participants to report any major medical event, medication, nutrition and lifestyle changes, physical and mental health, sexual dysfunction and overall quality of life as well as health care use. Participants are also asked to provide discharge letters or any kind of further information on their health such as diagnostic findings or images.

The study center is in contact with public authorities and the cancer register about vital status, cause of death and cancer incidence and in contact with involved health and pension insurances to match with related individual routine data.

All participants are mailed a questionnaire annually, which specifically asks to report any major medical event, medication, nutrition and lifestyle changes, physical and mental health, sexual dysfunction and overall quality of life as well as health care use. Participants are also asked to provide discharge letters or any kind of further information on their health such as diagnostic findings or images.

The study center is in contact with public authorities and the cancer register about vital status, cause of death and cancer incidence and in contact with involved health and pension insurances to match with related individual routine data.

All participants are mailed a questionnaire annually, which specifically asks to report any major medical event, medication, nutrition and lifestyle changes, physical and mental health, sexual dysfunction and overall quality of life as well as health care use. Participants are also asked to provide discharge letters or any kind of further information on their health such as diagnostic findings or images.

The study center is in contact with public authorities and the cancer register about vital status, cause of death and cancer incidence and in contact with involved health and pension insurances to match with related individual routine data.

All participants are mailed a questionnaire annually, which specifically asks to report any major medical event, medication, nutrition and lifestyle changes, physical and mental health, sexual dysfunction and overall quality of life as well as health care use. Participants are also asked to provide discharge letters or any kind of further information on their health such as diagnostic findings or images.

The study center is in contact with public authorities and the cancer register about vital status, cause of death and cancer incidence and in contact with involved health and pension insurances to match with related individual routine data.

All participants are mailed a questionnaire annually, which specifically asks to report any major medical event, medication, nutrition and lifestyle changes, physical and mental health, sexual dysfunction and overall quality of life as well as health care use. Participants are also asked to provide discharge letters or any kind of further information on their health such as diagnostic findings or images.

The study center is in contact with public authorities and the cancer register about vital status, cause of death and cancer incidence and in contact with involved health and pension insurances to match with related individual routine data.

After 6 years, all participants are invited to undergo the same examination and procedures as in the baseline visit.

Self-report questionnaires collect information about lifestyle and environmental conditions, dietary habits, quality of life, physical and sexual dysfunction, professional life, psychosocial context and burden, digital media use, medical and family history, occupational history as well as health care utilization.

Participants ungergo screening for impairment of cognitive function using the Mini-Mental State Exam (MMSE), and Clock Drawing Test (CDT).

Anthropometric measures, resting blood pressure measurements, ECG tracings as well as cardiovascular, cognitive and oral health phenotyping, skin screening, pulmonary function test, muscle tests and optical coherence tomography are performed.

Individuals identified at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited to the imaging examination including an MRI examination of the heart and the thoracic aorta and/or brain depending on the target disease.

Blood, urine, saliva as well as tooth fluid and tonsils swabs are collected. Additionally, from a random subset of study participants, skin stanza are collected of which fibroblasts are separated.