Italian Project on the Epidemiology of Alzheimer's Disease
The main objectives of IPREA were to define the prevalence, incidence, and risk factors of the preclinical phase of dementia (including Alzheimer's disease), analyzing also the transition to dementia and the predictive value of an extensive neuropsychological battery and of biological and instrumental markers.
Overview
- Acronym
- IPREA
- Website
- IPREA
- Investigators
-
Prof. Emanuele ScafatoIstituto Superiore Sanità (ISS) - National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS)
- Contacts
-
Dr. Lucia GalluzzoIstituto Superiore Sanità (ISS) - National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS)
General Design
- Study design
- Cohort
- Start - End Year
- 2003 - 2013
- General Information on Follow Up (profile, frequency)
-
The baseline recruitment started 2003 and the follow-up took place one year later. A 10-year follow-up of mortality from national death records is also available.
- Recruitment Target
-
- Individuals
- Number of Participants
- 4,785
- Number of Participants with Biological Samples
- 2,324
- Supplementary information about number of participants
-
IPREA has been supported by the Italian Ministry of Health (“Progetti strategici di ricerca finalizzata sulla malattia di Alzheimer” - D.Lgs. 502/92 and D.Lgs. 229/99; RF-2009-1539347, grant no. 287/2011).
- Supplementary Information
-
The baseline recruitment started 2003 and the follow-up took place one year later. A 10-year follow-up of mortality from national death records is also available.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Scafato E, Gandin C, Galluzzo L, Ghirini S, Cacciatore F, Capurso A, Solfrizzi V, Panza F, Cocchi A, Consoli D, Enzi G, Frisoni GB, Gandolfo C, Giampaoli S, Inzitari D, Maggi S, Crepaldi G, Mariotti S, Mecocci P, Motta M, Negrini R, Postacchini D, Rengo F, Farchi G; I.PR.E.A. Working Group (Italian PRoject on Epidemiology of Alzheimer’s disease). Prevalence of Aging-Associated Cognitive Decline - AACD in an Italian elderly population: results from the cross sectional phase of the Italian PRoject on theEpidemiology of Alzheimer's disease (I.PR.E.A.). Aging Clin Exp Res 2010;22(5-6):440-9
PUBMED 20383053Timeline
Population
IPREA - Population
The study population was composed of individuals aged 65-84 years, both community dwelling and institutionalized and living in 12 municipalities located across Italy.
Selection Criteria
- Minimum age
-
65
- Maximum age
-
84
- Countries
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- Italy
- Territory
- Rubano-Selvazzano (Padua, Veneto), Genoa (Liguria), Crevalcore (Bologna, Emilia Romagna), Impruneta (Florence, Tuscany), Bastia (Perugia, Umbria), Fermo (Marche), Tuscania (Viterbo, Lazio), Larino (Campobasso, Molise), Telese (Benevento, Campania), Casamassima (Bari, Puglia), Vibo Valentia (Calabria), Acicastello (Catania, Sicily)
- Health Status
-
- Absence of previous diagnosis of: severe dementia, terminal diseases, severe sensory impairment, psychoses, mental retardation
- Supplementary Information about selection criteria
-
At the end of the cross-sectional phase, complete information was available and a diagnostic conclusion reached for 2985 subjects; 420 of them underwent also a brain MRI scan. Biological specimens were also drawn from a subsample of 2324 participants. All subjects identified at baseline as affected by cognitive impairment without dementia (n=1387) were eligible for the longitudinal phase conducted after one year (total number of participants=1103).
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
All people aged 65-84 listed in the population registers of the 12 Italian participating towns as resident and alive on the 31.12.2002. The community based random sample was stratified by gender and 5-year age classes following an equal allocation strategy.
Sample Size
- Number of Participants
- 4,785
- Number of Participants with Biological Samples
- 2,324
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | IPREA - Mortality Follow-up |
|
2003 | 2012 | |
| 1 | IPREA - Baseline |
|
|
2003 (January) | 2004 (May) |
| 2 | IPREA - Follow-up |
|
2004 (May) | 2005 (May) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2023-08-10T18:19:02.145