Longevity Genes Project
The main purpose of the Longevity Genes Project (LGP) is to identify and characterize factors, biological markers and mechanisms leading to exceptionally long life span in healthy Ashkenazi Jews.
The LPG study is divided into two phases: phase 1 intends to explain the longevity phenotype of this specific population (how Ashkenazi Jews escape or delay many age-related diseases such as cancer, cardiovascular diseases, dementia and infections); whereas phase 2 (LonGenity) serves as a prospective validation cohort to confirm the findings from LGP.
Overview
- Acronym
- LGP
- Investigators
-
- Contacts
-
General Design
- Study design
- Case-control
- Start - End Year
- 1998 -
- General Information on Follow Up (profile, frequency)
-
Phase 1 participants were visited once by a member of the Einstein Institute for aging research and were not followed-up. Phase 2 participants were followed annually.
- Recruitment Target
-
- Families
- Number of Participants
- 2,680
- Supplementary information about number of participants
-
Most super agers were recruited as family units.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Papers
Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR. 2014. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA; 290(15):2030-40.
PUBMED 14559957Timeline
Populations
LGP - Offspring of super agers
Members of the offspring group were of Ashkenazi Jewish descent, and had at least one parent who lived to be 95 years or older.
Selection Criteria
- Countries
-
- United States of America
- Ethnic Origin
-
- Ashkenazi Jews
- Other Criteria
- Participants were excluded if they had a diagnosis of dementia, severe visual or hearing impairments.
Sources of Recruitment
- Specific Population
-
- Other specific population : Offspring of the super agers enrolled in the study.
- Supplementary Information
-
LGP offspring of super agers were recruited between 1998-2007.
Sample Size
- Number of Participants
- 700
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LGP - Offspring of Super Agers - 2006 |
|
|
1998 | 2007 |
LGP - Offspring of those with typical survival
This control group is composed of the Ashkenazi spouses of the super agers' offspring and age-matched Ashkenazi Jews recruited from the Einstein Aging Study, neither of which are known to have a family history of exceptional longevity or to carry longevity genes or phenotypes.
Selection Criteria
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Supplementary Information about selection criteria
-
Participants were excluded if they had a diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Sources of Recruitment
- Specific Population
-
- Other specific population : Spouses of the Super Agers offspring already enrolled in the study.
- Participants from Existing Studies
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- Einstein Aging Study
- Supplementary Information
-
The spouses were recruited via the super agers' offspring. The other participants were recruited from the Einstein Aging Study.
Sample Size
- Number of Participants
- 280
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LGP - Offspring of those with typical survival - 2006 |
|
|
1998 | 2007 |
LGP - Super agers
The participants selected were Ashkenazi Jews, aged 95 years or older at the time of recruitment and who lived independently.
Selection Criteria
- Minimum age
-
95
- Countries
-
- United States of America
- Territory
- New York area
- Ethnic Origin
-
- Ashkenazi Jews
- Other Criteria
- To be eligible, participants were required to be living independently at age 95, as a reflection of good health, although at the time of recruitment they could be at any level of dependency.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Participants from Existing Studies
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- Some participants were from LonGenity study when they turned 95.
- Supplementary Information
-
Subjects were recruited by word of mouth and through advertisements in Jewish aging centers and homes. They were recruited from 1998 and are still being recruited.
Sample Size
- Number of Participants
- 600
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LGP - Super Agers - 1998 |
|
|
1998 | 2017 |
LGP - LonGenity offspring of super agers
The participants were the offspring of parents with exceptional longevity (OPEL). Genetic findings from the super agers were validated with this cohort.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Supplementary Information about selection criteria
-
Exclusion criterion included diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Sources of Recruitment
- Specific Population
-
- Other specific population : Ashkenazi Jews (your family was originally from Eastern Europe: Germany, Russia, Poland, Hungary, Czechoslovakia, Rumania, etc.)
- Participants from Existing Studies
-
- Longevity Genes Project
- Einstein Aging study
- Supplementary Information
-
Participants were recruited from 2008 and are still being recruited. They were recruited using public records such as voter registration lists, contacts at synagogues, community organizations, and advertisements in Jewish newspapers. Some offspring from LGP are included, although this is a minority of subjects.
Sample Size
- Number of Participants
- 530
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LGP - LonGenity offspring of super agers - Assessment 1 |
|
|
2008 | 2017 |
| 1 | LGP - LonGenity offspring of super agers - Assessment 2 |
|
2009 | 2017 | |
| 2 | LGP - LonGenity offspring of super agers - Assessment 3 |
|
|
2010 | 2017 |
| 3 | LGP - LonGenity offspring of super agers - Assessment 4 |
|
2011 | 2017 | |
| 4 | LGP - LonGenity offspring of super agers - Assessment 5 |
|
|
2012 | 2017 |
| 5 | LGP - LonGenity offspring of super agers - Assessment 6 |
|
2013 | 2017 | |
| 6 | LGP - LonGenity offspring of super agers - Assessment 7 |
|
|
2014 | 2017 |
| 7 | LGP - LonGenity offspring of super agers - Assessment 8 |
|
2015 | 2017 | |
| 8 | LGP - LonGenity offspring of super agers - Assessment 9 |
|
|
2016 | 2017 |
| 9 | LGP - LonGenity offspring of super agers - Assessment 10 |
|
2017 | 2017 |
LGP - LonGenity offspring of those with typical survival
Participants were the offspring of parents with usual survival (OPUS). They were the control group in the LonGenity study.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Territory
- New York
- Ethnic Origin
-
- Ashkenazi Jews
- Supplementary Information about selection criteria
-
Exclusion criterion included diagnosis of dementia, severe visual or hearing impairments as well as having a sibling already enrolled in the study.
Sources of Recruitment
- Specific Population
-
- Other specific population : Other specific population Ashkenazi Jews (your family was originally from Eastern Europe: Germany, Russia, Poland, Hungary, Czechoslovakia, Rumania, etc.)
- Participants from Existing Studies
-
- Einstein Aging Study
- Supplementary Information
-
Participants were recruited from 2008 and are still being recruited. They were recruited using public records such as voter registration lists, contacts at synagogues, community organizations, and advertisements in Jewish newspapers.Some offspring from LGP are included, although this is a minority of subjects.
Sample Size
- Number of Participants
- 570
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LGP - LonGenity offspring of those with typical survival - Assessment 1 |
|
|
2008 | 2017 |
| 1 | LGP - LonGenity offspring of those with typical survival - Assessment 2 |
|
2009 | 2017 | |
| 2 | LGP - LonGenity offspring of those with typical survival - Assessment 3 |
|
|
2010 | 2017 |
| 3 | LGP - LonGenity offspring of those with typical survival - Assessment 4 |
|
2011 | 2017 | |
| 4 | LGP - LonGenity offspring of those with typical survival - Assessment 5 |
|
|
2012 | 2017 |
| 5 | LGP - LonGenity offspring of those with typical survival - Assessment 6 |
|
2013 | 2017 | |
| 6 | LGP - LonGenity offspring of those with typical survival - Assessment 7 |
|
|
2014 | 2017 |
| 7 | LGP - LonGenity offspring of those with typical survival - Assessment 8 |
|
2015 | 2017 | |
| 8 | LGP - LonGenity offspring of those with typical survival - Assessment 9 |
|
|
2016 | 2017 |
| 9 | LGP - LonGenity offspring of those with typical survival - Assessment 10 |
|
2017 | 2017 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2023-05-03T11:13:55.607