LifeLines Cohort Study & Biobank
Overall aim of the LifeLines study is to unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait. The primary objectives are to establish which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime, and how are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual. Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiology, renal diseases, pulmonary and musculoskeletal diseases, and psychopathology. Secondary objectives include the assessment of the prevalence and incidence of multifactorial diseases and their risk factors in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.
Overview
- Acronym
- LifeLines
- Investigators
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- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2007 -
- General Information on Follow Up (profile, frequency)
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The participants are followed for at least thirty years and are invited every five years for a medical examination. In the years in-between (every 1.5 years) the participants recieve follow-up questionnaires.
- Recruitment Target
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- Individuals
- Families
- Number of Participants
- 165,000
- Number of Participants with Biological Samples
- 165,000
- Supplementary information about number of participants
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45 000 probands who invite their family members (30000 partners, 55000 parents (including in laws) and 35000 children).
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Papers
Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74.
PUBMED 18075776Supplementary Information
Funding Agencies: Governement, 3 northern provinces of The Netherlands (80%), University Med Center Groningen/ University of Groningen (15%), The Netherlands Organization for Scientific Research (NWO) (5%), Dutch Diabetes Research Foundation and Dutch Kidney Foundation
Timeline
Population
The study population consists of a representative sample of the population of the northern provinces of the Netherlands, covering three generations. The LifeLines project will include 165.000 participants: anticipated to consist of approximately45.000 probands, 30.000 partners, 55.000 parents-(in law) and 35.000 children. Based on the age of the participant, he or she is included in the children’s cohort (0-18 years), the adult cohort (18-65 years) or the elderly cohort (>65 years).
Selection Criteria
- Countries
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- Netherlands
- Territory
- Groningen, Friesland and Drenthe
- Health Status
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- Severe psychiatric or physical illness are excluded
Sources of Recruitment
- General Population
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- Volunteer enrolment
Sample Size
- Number of Participants
- 165,000
- Number of Participants with Biological Samples
- 165,000
- Supplementary information about number of participants
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155000 participants as of 19 Sept 2013
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | Lifelines - Preparation phase/pilot | 2004 | 2006 | ||
| 1 | Lifelines - Baseline visit |
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2007 | 2013 |
| 2 | Lifelines - Follow-up questionnaire 1 |
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2010 | 2014 | |
| 3 | Lifelines - Follow-up questionnaire 2 |
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2012 | 2015 | |
| 4 | Lifelines - Follow-up visit 1 |
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2014 | 2017 |
| 5 | Lifelines - Follow-up questionnaire 3 |
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2014 | 2017 |
Participating Studies
| Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
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Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
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