Long-term Immune Protection in COVID-19 Patients
The overall goal of the study is to identify the mechanism of response of our immune system to the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The specific objectives are to:
* Test patients' ability to neutralize the SARS-CoV-2 by measuring circulating antibodies;
* Study memory immune cells that offer long-term protection; and
* Compare the short and long-term immune responses to SARS-CoV-2 infection and vaccination.
Overview
- Acronym
- LIPiC
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2020 -
- General Information on Follow Up (profile, frequency)
-
For the COVID-19 positive and negative cohorts, paticipant's antibodies are tested approximately 14 days after the onset of symptoms (baseline), 6 months and 1 year later. For the COVID-19 vaccinated cohort, antibody testing will be conducted up to 5 times: baseline (pre-vaccination), 3 weeks after first vacinnation, 3 weeks after second vaccination, 6 months and 12 months post-vaccination.
- Recruitment Target
-
- Individuals
- Number of Participants
- 600
- Number of Participants with Biological Samples
- 600
- Supplementary information about number of participants
-
COVID-19 positive cohort planned to be conducted on approximately 200 patients
COVID-19 negative cohort planned to be conducted on approximately 200 patients
COVID-19 vaccinated cohort planned to be conducted on approximately 200 non-infected participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Timeline
Populations
LIPiC - Positive Cohort
The population is composed of patients who recovered from COVID-19 infection in Hamilton, Ontario, Canada and who were tested as positive from the reverse transcriptase polymerase chain reaction (RT-PCR) test.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton, Ontario
- Health Status
-
- Recovered from COVID-19 infection
- Other Criteria
- Tested as positive from the reverse transcriptase polymerase chain reaction (RT-PCR) test
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Study participants were recruited from patients who recovered from COVID-19 infection and were initially identified by treating physicians, Public Health and through hospital discharge databases that include hospitals in Hamilton, Ontario, Canada (Hamilton General Hospital, Juravinski Hospital, McMaster University Medical Centre, and St. Joseph’s Healthcare).
Sample Size
- Number of Participants
- 200
- Number of Participants with Biological Samples
- 200
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LIPiC - Positive Cohort - Baseline |
|
|
2020 (September) | Ongoing |
| 1 | LIPiC - Positive Cohort - Follow-up 1 |
|
|
2021 (March) | Ongoing |
| 2 | LIPiC - Positive Cohort - Follow-up 2 |
|
|
2021 (September) | Ongoing |
LIPiC - Negative Cohort
The population is composed of patients who recovered from COVID-19 infection in Hamilton, Ontario, Canada and who were tested as negative from the reverse transcriptase polymerase chain reaction (RT-PCR) test.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton, Ontario
- Health Status
-
- Recovered from COVID-19 infection
- Other Criteria
- Tested as negative from the reverse transcriptase polymerase chain reaction (RT-PCR) test
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Study participants were recruited from patients who recovered from COVID-19 infection and were initially identified by treating physicians, Public Health and through hospital discharge databases that include hospitals in Hamilton, Ontario, Canada (Hamilton General Hospital, Juravinski Hospital, McMaster University Medical Centre, and St. Joseph’s Healthcare).
Sample Size
- Number of Participants
- 200
- Number of Participants with Biological Samples
- 200
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LIPiC - Negative Cohort - Baseline |
|
|
2020 (September) | Ongoing |
| 1 | LIPiC - Negative Cohort - Follow-up 1 |
|
|
2021 (March) | Ongoing |
| 2 | LIPiC - Negative Cohort - Follow-up 2 |
|
|
2021 (September) | Ongoing |
LIPiC - Vaccinated Cohort
The population is composed of non-infected individuals who are planning to be vaccinated with the vaccines against SARS-CoV-2.
Selection Criteria
- Countries
-
- Canada
- Canadian Provinces
-
- Ontario
- Territory
- Hamilton, Ontario
- Health Status
-
- Non-infected with COVID-19
- Other Criteria
- Planning to be vaccinated with vaccines against SARS-CoV-2
Sources of Recruitment
- General Population
-
- Selected sample
Sample Size
- Number of Participants
- 200
- Number of Participants with Biological Samples
- 200
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LIPiC - Vaccinated Cohort - Baseline |
|
|
2021 (March) | Ongoing |
| 1 | LIPiC - Vaccinated Cohort - 3 weeks post-vaccination 1 |
|
|
2021 (April) | Ongoing |
| 2 | LIPiC - Vaccinated Cohort - 3 weeks post-vaccination 2 |
|
|
2021 (May) | Ongoing |
| 3 | LIPiC - Vaccinated Cohort - 6 months post-vaccination |
|
|
2021 (September) | Ongoing |
| 4 | LIPiC - Vaccinated Cohort - 12 months post-vaccination |
|
|
2022 (March) | Ongoing |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-04-04T17:12:00.211