Longitudinal study on prevalence, incidence and persistence of SARS-CoV-2 antibodies in health care workers using home blood collection kits and a fully automated ELISA and ECLIA antibody assay
The objectives of this study are:
1. To compare home blood collection kit using a micro-tube or a dried blood spot.
2. To provide rates of previous and new infections with COVID-19 and re-infection rates in health care workers (HCWs). This should help to understand if immunity is durable and provides future resistance to COVID-19 infection.
Overview
- Acronym
- LSPIPSA-HCW
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2020 - 2022
- General Information on Follow Up (profile, frequency)
-
For the longitudinal participants, follow-up questionnaires were completed at 3, 6, 12 and 18 months following the initial assays; and 30 days after the completion of the vaccination. An identical process was followed for the serological testing 3, 6, 12 and 18 months following the initial assays; and 30 days after the completion of vaccination.
- Recruitment Target
-
- Individuals
- Number of Participants
- 1,720
- Number of Participants with Biological Samples
- 1,720
- Supplementary information about number of participants
-
COVID-19 infected: 10 participants
COVID-19 negative and untested: 10 participants
Mount Sinai Hospital: 1200 Participants
Health Science North (Sudbury): 250 Participants
Sault Area Hospital (Sault Ste Marie): 250 Participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Timeline
Populations
LSPIPSA-HCW - COVID-19 infected
The population is composed of COVID-19 positive and recovered patients from Mount Sinai Hospital with a previous COVID-19 positive test by naso-pharyngeal swab.
Selection Criteria
- Countries
-
- Canada
- Territory
- Toronto
- Health Status
-
- COVID-19 positive and recovered
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
COVID-19 positive and recovered patients are recruited from Mount Sinai Hospital patient population. Patients are approached to participate, then they are provided with the consent form and information on how to contact the research coordinator for this study. The COVID-19 infected patients participate in this study after they have recovered from the infection and are no longer infected (not hospitalized patients).
Sample Size
- Number of Participants
- 10
- Number of Participants with Biological Samples
- 10
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LSPIPSA-HCW - COVID-19 infected - ELISA capillary blood samples |
|
|
2020 (September) | Ongoing |
LSPIPSA-HCW - COVID-19 negative and untested
The population is composed of health care workers at the Mount Sinai Hospital, COVID-19 untested or previously negative.
Selection Criteria
- Countries
-
- Canada
- Territory
- Toronto
- Health Status
-
- COVID-19 untested or previously negative
Sources of Recruitment
- Specific Population
-
- Members of an association
- Supplementary Information
-
Participants will be recruited by word of mouth from within the health care workers at the Mount Sinai Hospital.
Sample Size
- Number of Participants
- 10
- Number of Participants with Biological Samples
- 10
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LSPIPSA-HCW - COVID-19 negative and untested - ELISA capillary blood samples |
|
|
2020 (September) | Ongoing |
LSPIPSA-HCW - Longitudinal
The population is composed of Mount Sinai Hospital (MSH), Sault Area Hospital and Health Sciences North (Sudbury) health care workers.
Selection Criteria
- Countries
-
- Canada
- Territory
- Ontario
- Other Criteria
- Exclusion: Present symptoms compatible with COVID-19 infections and for those with confirmed COVID-19 positive had a negative NP swab test for COVID-19 (recovered from COVID-19)
Sources of Recruitment
- Specific Population
-
- Members of an association
- Supplementary Information
-
Information about this study was electronically distributed to the health care workers (HCWs) at the Mount Sinai Hospital, Sault Area Hospital and Health Sciences North (Sudbury). Volunteers will contact the research coordinator and will be eligible to participate in the study if they are able to provide the blood samples and if they are willing to complete the entire 18 months of the study.
Sample Size
- Number of Participants
- 1,700
- Number of Participants with Biological Samples
- 1,700
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | LSPIPSA-HCW - Longitudinal - Blood collection |
|
|
2020 (September) | Ongoing |
| 1 | LSPIPSA-HCW - Longitudinal - 3 months follow-up |
|
|
2020 (December) | Ongoing |
| 2 | LSPIPSA-HCW - Longitudinal - 6 months follow-up |
|
|
2021 (March) | Ongoing |
| 3 | LSPIPSA-HCW - Longitudinal - 12 months follow-up |
|
|
2021 (September) | Ongoing |
| 4 | LSPIPSA-HCW - Longitudinal - 18 months follow-up |
|
|
2022 (March) | 2022 |
| 5 | LSPIPSA-HCW - Longitudinal - 1 month post-vaccination |
|
|
2021 (February) | 2021 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2021-10-19T15:00:04.902