Long-term outcomes following COVID-19 in Pediatrics

The primary objective of the Long-term outcomes following COVID-19 in Pediatrics study is to determine the long-term healthcare resource utilization and health care costs among pediatric survivors of COVID-19 infection. The second objective of this study is to describe and compare the hospitalization characteristics, longitudinal health care utilization, mortality and risk of long-term sequalae between children hospitalized for COVID-19 infections and children hospitalized for other respiratory infections.

Overview

Acronym
POPCORN-LTO
Website
POPCORN-LTO
Investigators
Dr. Karen Choong
McMaster University
Contacts
Dr. Karen Choong
McMaster University

General Design

Study design
Cohort
Start - End Year
2020 - 2024
General Information on Follow Up (profile, frequency)
Participants are followed up 1 to 3 times after the baseline assessment.
Recruitment Target
  • Individuals
Number of Participants
No Limit
Supplementary information about number of participants
Because administrative health databases capture essentially the entire pediatric population covered by provincial insurance, there isn’t a fixed cap on the number of “participants.”
Supplementary Information
This study uses administrative health data that do not have any patient identifiers. Data for this study will be provided by the Canadian Institute for Health Information (CIHI), which contains the National Ambulatory Care Reporting System database (NACRS) and the Discharge Abstract Database (DAD) for all provinces except Quebec. A two-year lookback window from index hospital admission will be used to ascertain for baseline medical complexity of the participant.

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Timeline

Populations

POPCORN-LTO - COVID Cohort
The population is composed of children and youth aged 18 years or younger living in any province and territories of Canada who were infected with COVID-19 and were hospitalized for their infection.

Selection Criteria

Maximum age
18
Countries
  • Canada
Canadian Provinces
  • Alberta
  • British Columbia
  • Manitoba
  • New Brunswick
  • Newfoundland and Labrador
  • Northwest Territories
  • Nova Scotia
  • Nunavut
  • Ontario
  • Prince Edward Island
  • Quebec
  • Saskatchewan
  • Yukon
Health Status
  • Participants hospitalized for COVID-19 are identified using the following codes listed as the Most Responsible Diagnosis (MRDx) for their hospital encounter: * U07.1 for confirmed COVID-19 or * U07.2 for suspected COVID-19 or * U07.3 for Multisystem inflammatory syndrome associated with COVID-19 (MIS-C)

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Participants are identified from the Canadian Institute for Health Information (CIHI) databases such as National Ambulatory Care Reporting System database (NACRS) and Discharge Abstract Database (DAD). Participants from Québec are exclusively identified from the Institute National d’Excellence en Santé et Services Sociaux (INESSS).

Sample Size

Number of Participants
No Limit

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 POPCORN-LTO - COVID Cohort - Baseline
  • Administrative databases
2020 (April) 2023 (March)
1 POPCORN-LTO - COVID Cohort - Follow-up
  • Administrative databases
2023 (April) 2024 (March)
POPCORN-LTO - Matched Cohort
The population is composed of children aged 18 years old or younger living in any province and territories of Canada who were hospitalized for a non-COVID-19 infection affecting the upper or lower respiratory tract.

Selection Criteria

Maximum age
18
Countries
  • Canada
Canadian Provinces
  • Alberta
  • British Columbia
  • Manitoba
  • New Brunswick
  • Newfoundland and Labrador
  • Northwest Territories
  • Nova Scotia
  • Nunavut
  • Ontario
  • Prince Edward Island
  • Quebec
  • Saskatchewan
  • Yukon
Health Status
  • Participants must have been hospitalized and their "Most Responsible Diagnosis" (MRDx) must be an upper or lower respiratory tract infection, such as: * Influenza, parainfluenza * RSV bronchiolitis * Pneumonia * Croup * Infection associated with rhinovirus * Human metapneumovirus * Enterovirus * Other non-COVID-19 coronaviruses
Supplementary Information about selection criteria
Participants are selected to match the COVID cohort based on the following characteristics: * Sex * Month/year of hospitalization (to account for COVID waves) * Province * Deprivation quintile

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Participants are identified from the Canadian Institute for Health Information (CIHI) databases such as National Ambulatory Care Reporting System database (NACRS) and Discharge Abstract Database (DAD). Participants from Québec are exclusively identified from the Institute National d’Excellence en Santé et Services Sociaux (INESSS).

Sample Size

Number of Participants
No Limit

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 POPCORN-LTO - Matched Cohort - Baseline
  • Administrative databases
2020 (April) 2023 (March)
1 POPCORN-LTO - Matched Cohort - Follow-up
  • Administrative databases
2023 (April) 2024 (March)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2026-02-20T15:29:31.228