Maastricht Ageing Study

Overview

Acronym
MAAS
Website
MAAS
Investigators
  • Pr. Martin van Boxtel
    Maastricht University
  • Pr. Sebastian Köhler
    Maastricht University
Contacts
  • Pr. Sebastian Köhler
    Maastricht University

General Design

Study design
Cohort
Start Year
1992
End Year
2020
General Information on Follow Up (profile, frequency)
The frequency of follow-up depends on actual age, i.e. three, six, nine, twelve and 25 years for subjects aged 50 years and older, and six, nine, twelve and 25-years for younger subjects. The third follow-up (9 years) consists of a full questionnaire survey. The total duration of the follow-up program is 25 years, closing with a full questionnaire survey and the final cognitive assessment in the laboratory.
Recruitment Target
  • Individuals
Number of Participants
1,823
Number of Participants with Biological Samples
954

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Marker Paper

Jolles, J., van Boxtel, M. P. J., Ponds, R. W. H. M., Metsemakers, J. F. M., & Houx, P. J. (1998). De Maastricht Aging Study (MAAS): Het longitudinaal perspectief van cognitieve veroudering. Tijdschrift voor Gerontologie en Geriatrie 29(3): 120-129

PUBMED 9675779

Supplementary Information

Four panel studies (A1-A2-A3-A4) were executed between 1993 and 1995, sharing the same methodology with respect to sample frame, subject inclusion and stratification criteria, and basic measurement protocol. Each A-study includes an independent population sample and a set of specific variables in addition to the set of variables that is constant for all A-studies. Following this cross-sectional phase, panels were assessed in the longitudinal phase of the study.

Timeline

Populations

MAAS - A1

Selection Criteria

Minimum age
24
Maximum age
86
Countries
  • Netherlands
Territory
Province of Limburg
Other Criteria
Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.

Sources of Recruitment

General Population
  • Selected sample
Supplementary Information
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.

Sample Size

Number of Participants
2,043
Supplementary Information
Baseline Postal Survey: 2043 participants
Baseline Test Program: 470 participants
Follow-up 1: 212 participants (50 years old and older only)
Follow-up 2: 330 participants
Follow-up 3: 343 participants
Follow-up 4: 301 participants

Data Collection Events

# Name Description Start End
0 MAAS - A1 - Baseline Postal Survey 1992 (September) 1992 (December)
1 MAAS - A1 - Baseline Test Program 1993 (February) 1993 (October)
2 MAAS - A1 - Follow-up 1 1996 (July) 1996 (December)
3 MAAS - A1 - Follow-up 2 1999 (June) 1999 (December)
4 MAAS - A1 - Follow-up 3 2002 (June) 2002 (December)
5 MAAS - A1 - Follow-up 4 2005 (June) 2005 (December)
MAAS - A2

Selection Criteria

Minimum age
24
Maximum age
86
Countries
  • Netherlands
Territory
Province of Limburg
Other Criteria
Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.

Sample Size

Number of Participants
496
Supplementary Information
Baseline: 496 participants
Follow-up 1: 211 participants
Follow-up 2: 343 participants
Follow-up 3: 339 participants
Follow-up 4: 288 participants

Data Collection Events

# Name Description Start End
0 MAAS - A2 - Baseline 1994 (June) 1994 (December)
1 MAAS - A2 - Follow-up 1 1997 (June) 1997 (December)
2 MAAS - A2 - Follow-up 2 2000 (June) 2000 (December)
3 MAAS - A2 - Follow-up 3 2003 (June) 2003 (December)
4 MAAS - A2 - Follow-up 4 2006 (June) 2006 (December)
MAAS - A3

Selection Criteria

Minimum age
24
Maximum age
86
Countries
  • Netherlands
Territory
Province of Limburg
Other Criteria
Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.

Sample Size

Number of Participants
459
Supplementary Information
Baseline: 459 participants
Follow-up 1: 215 participants
Follow-up 2: 358 participants
Follow-up 3: 345 participants
Follow-up 4: 318 participants

Data Collection Events

# Name Description Start End
0 MAAS - A3 - Baseline 1994 (November) 1995 (June)
1 MAAS - A3 - Follow-up 1 1997 (November) 1998 (May)
2 MAAS - A3 - Follow-up 2 2000 (November) 2001 (May)
3 MAAS - A3 - Follow-up 3 2003 (November) 2004 (May)
4 MAAS - A3 - Follow-up 4 2006 (November) 2007 (May)
MAAS - A4

Selection Criteria

Minimum age
24
Maximum age
86
Countries
  • Netherlands
Territory
Province of Limburg.
Other Criteria
Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.

Sources of Recruitment

Specific Population
  • Clinic patients
Supplementary Information
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.

Sample Size

Number of Participants
436
Supplementary Information
Baseline: 436 participants
Follow-up 1: 200 participants
Follow-up 2: 345 participants
Follow-up 3: 323 participants
Follow-up 4: 280 participants

Data Collection Events

# Name Description Start End
0 MAAS - A4 - Baseline 1995 (May) 1995 (November)
1 MAAS - A4 - Follow-up 1 1998 (May) 1998 (November)
2 MAAS - A4 - Follow-up 2 2001 (May) 2001 (November)
3 MAAS - A4 - Follow-up 3 2004 (May) 2004 (November)
4 MAAS - A4 - Follow-up 4 2007 (May) 2007 (November)

Individual Studies Included

Acronym Name Study design Participants Countries

Harmonization Projects Included

Acronym Name

Networks

Acronym Name Studies

Datasets

Name Type Data Collection Events Variables
Last Update: 2020-02-05 16:07