Maastricht Ageing Study
A major objective of this study is to find determinants of cognitive deterioration with age, and to estimate their relative impact. The aim of MAAS is to relate various factors (biological, medical, psychological and social) in an integrative study of cognitive aging.
Overview
- Acronym
- MAAS
- Website
- MAAS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1992 - 2020
- General Information on Follow Up (profile, frequency)
-
The frequency of follow-up depends on actual age, i.e. three, six, nine, twelve and 25 years for subjects aged 50 years and older, and six, nine, twelve and 25-years for younger subjects. The third follow-up (9 years) consists of a full questionnaire survey. The total duration of the follow-up program is 25 years, closing with a full questionnaire survey and the final cognitive assessment in the laboratory.
- Recruitment Target
-
- Individuals
- Number of Participants
- 1,823
- Number of Participants with Biological Samples
- 954
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Jolles, J., van Boxtel, M. P. J., Ponds, R. W. H. M., Metsemakers, J. F. M., & Houx, P. J. (1998). De Maastricht Aging Study (MAAS): Het longitudinaal perspectief van cognitieve veroudering. Tijdschrift voor Gerontologie en Geriatrie 29(3): 120-129
PUBMED 9675779Supplementary Information
Four panel studies (A1-A2-A3-A4) were executed between 1993 and 1995, sharing the same methodology with respect to sample frame, subject inclusion and stratification criteria, and basic measurement protocol. Each A-study includes an independent population sample and a set of specific variables in addition to the set of variables that is constant for all A-studies.
Following this cross-sectional phase, panels were assessed in the longitudinal phase of the study.
Timeline
Populations
MAAS - A1
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex and levels of occupational activity (high/low).
Selection Criteria
- Minimum age
-
24
- Maximum age
-
86
- Countries
-
- Netherlands
- Territory
- Province of Limburg
- Other Criteria
- Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.
Sample Size
- Number of Participants
- 2,043
- Supplementary information about number of participants
-
Baseline Postal Survey: 2043 participants
Baseline Test Program: 470 participants
Follow-up 1: 212 participants (50 years old and older only)
Follow-up 2: 330 participants
Follow-up 3: 343 participants
Follow-up 4: 301 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAAS - A1 - Baseline Postal Survey |
|
1992 (September) | 1992 (December) | |
| 1 | MAAS - A1 - Baseline Test Program |
|
1993 (February) | 1993 (October) | |
| 2 | MAAS - A1 - Follow-up 1 |
|
|
1996 (July) | 1996 (December) |
| 3 | MAAS - A1 - Follow-up 2 |
|
1999 (June) | 1999 (December) | |
| 4 | MAAS - A1 - Follow-up 3 |
|
2002 (June) | 2002 (December) | |
| 5 | MAAS - A1 - Follow-up 4 |
|
2005 (June) | 2005 (December) |
MAAS - A2
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Selection Criteria
- Minimum age
-
24
- Maximum age
-
86
- Countries
-
- Netherlands
- Territory
- Province of Limburg
- Other Criteria
- Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.
Sample Size
- Number of Participants
- 496
- Supplementary information about number of participants
-
Baseline: 496 participants
Follow-up 1: 211 participants
Follow-up 2: 343 participants
Follow-up 3: 339 participants
Follow-up 4: 288 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAAS - A2 - Baseline |
|
1994 (June) | 1994 (December) | |
| 1 | MAAS - A2 - Follow-up 1 |
|
1997 (June) | 1997 (December) | |
| 2 | MAAS - A2 - Follow-up 2 |
|
2000 (June) | 2000 (December) | |
| 3 | MAAS - A2 - Follow-up 3 |
|
2003 (June) | 2003 (December) | |
| 4 | MAAS - A2 - Follow-up 4 |
|
2006 (June) | 2006 (December) |
MAAS - A3
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Selection Criteria
- Minimum age
-
24
- Maximum age
-
86
- Countries
-
- Netherlands
- Territory
- Province of Limburg
- Other Criteria
- Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.
Sample Size
- Number of Participants
- 459
- Supplementary information about number of participants
-
Baseline: 459 participants
Follow-up 1: 215 participants
Follow-up 2: 358 participants
Follow-up 3: 345 participants
Follow-up 4: 318 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAAS - A3 - Baseline |
|
1994 (November) | 1995 (June) | |
| 1 | MAAS - A3 - Follow-up 1 |
|
1997 (November) | 1998 (May) | |
| 2 | MAAS - A3 - Follow-up 2 |
|
2000 (November) | 2001 (May) | |
| 3 | MAAS - A3 - Follow-up 3 |
|
2003 (November) | 2004 (May) | |
| 4 | MAAS - A3 - Follow-up 4 |
|
2006 (November) | 2007 (May) |
MAAS - A4
Men and women aged 24 to 86 years at baseline and in general good health, sampled from the Registration Network Family Practices (Registratienet Huisartspraktijken, RNH) and stratified by age (12 strata), sex, and levels of occupational activity (high/low).
Selection Criteria
- Minimum age
-
24
- Maximum age
-
86
- Countries
-
- Netherlands
- Territory
- Province of Limburg.
- Other Criteria
- Medical exclusion criteria for the subject sampling procedure at baseline were defined as those active or inactive medical conditions in the RNH problem list that may interfere with normal cognitive function. This definition included: chronic neurological pathology (dementia, mental retardation, cerebrovascular disease, epilepsy, parkinsonism, and CNS malignancies) or chronic psychotropic drug use, history of transient ischemic attackes (ITA), brain surgery, hemodialysis for renal failure, and electroconvulsive therapy. A score below 24 on the MMSE also excluded participants.
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Participants of MAAS were recruited from the Registration Network Family Practices (RNH) which contains the demographic and health characteristics of patients from 15 general practices in the province of Limburg. The request for participation in the study was made by the individual's general practitioner. Note that in the Netherlands, every person is registered within the RNH.
Sample Size
- Number of Participants
- 436
- Supplementary information about number of participants
-
Baseline: 436 participants
Follow-up 1: 200 participants
Follow-up 2: 345 participants
Follow-up 3: 323 participants
Follow-up 4: 280 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MAAS - A4 - Baseline |
|
1995 (May) | 1995 (November) | |
| 1 | MAAS - A4 - Follow-up 1 |
|
1998 (May) | 1998 (November) | |
| 2 | MAAS - A4 - Follow-up 2 |
|
2001 (May) | 2001 (November) | |
| 3 | MAAS - A4 - Follow-up 3 |
|
2004 (May) | 2004 (November) | |
| 4 | MAAS - A4 - Follow-up 4 |
|
2007 (May) | 2007 (November) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2023-08-10T18:18:37.601