Multi-Ethnic Study of Atherosclerosis - Neighbourhood

    The overall goal of the MESA Neighbourhood study are to examine longitudinal associations of specific features of neighborhood environments (and changes in neighborhood environments) with changes in key risk factors over time and with incident cardiovascular events, and to investigate the contributions of neighborhoods to race/ethnic and socioeconomic differences in cardiovascular risk. The specific aims are:
  • To examine associations of specific neighborhood characteristics and changes in neighborhood characteristics (including measures of access to healthy foods, walkability and urban design, access to recreational resources, and neighborhood stressors) with changes in diet, physical activity, and body weight over time;
  • To examine associations of neighborhood characteristics and changes in neighborhood characteristics with incident diabetes and hypertension as well as with changes over time in continuous measures of insulin resistance and blood pressure;
  • To examine associations of neighborhood characteristics with incident fatal and non fatal cardiovascular events;
  • To investigate the contribution of neighborhood environments to race/ethnic and socioeconomic differences in longitudinal changes in risk factors and incident disease; and
  • To establish and maintain a rich database of longitudinal environmental exposures for MESA participants that can be used in future gene environment interaction studies.

Overview

Acronym
MESA Neighbourhood
Website
MESA Neighbourhood
Investigators
Dr Ana Diez Roux
Dornsife School of Public Health at Drexel University
Dr. Mahasin S. Mujahid
Berkley School of Public Health, University of California
Dr. Jana A. Hirsch
Arnold School of Public Health University of South Carolina
Kari Moore
Urban Health Collaborative, Drexel University Dornsife School of Public Health
Dr. Latetia V. Moore
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention
Dr. Amy Auchincloss
Drexel University
Contacts
Kari Moore
Urban Health Collaborative, Drexel University Dornsife School of Public Health

General Design

Study design
Cohort
Start - End Year
2000 -
General Information on Follow Up (profile, frequency)
Participants were assessed 5 times. Baseline was in 7/2000-8/2002; Follow-up 1 in 7/2002-2/2004; Follow-up 2 in 1/2004-9/2005; Follow-up 3 in 9/2005-5/2007; Follow-up 4 in 4/2010-2/2012.
Recruitment Target
  • Individuals
Number of Participants
6,191

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other

Marker Paper

Diez Roux, Ana V. et al. "The Impact Of Neighborhoods On CV Risk". Global Heart 11.3 (2016): 353-363.

PUBMED 27741982

Timeline

Population

MESA Neighbourhood population
The population consisted of individuals aged 45 to 84 years from various ethnic backgrounds.

Selection Criteria

Minimum age
45
Maximum age
84
Countries
  • United States of America
Territory
Baltimore; Chicago; Forsyth County, NC; Los Angeles; New York; and St Paul, MN
Health Status
  • Participants with known clinical cardiovascular disease were excluded from recruitment (physician diagnosed heart attack, angina or taking nitroglycerin, stroke, TIA, heart failure, current atrial fibrillation, undergone procedures related to CVD (CABG, angioplasty, valve replacement, pacemaker, surgery of heart or arteries).

Sources of Recruitment

General Population
  • Selected sample
  • Random digit dialing
Supplementary Information
The sampling frame and methods for potential participants varied by field center, depending on the nature of the local sampling frame and logistics. The sampling unit was the household, and all eligible participants who resided in a single household were recruited for the study.

Sample Size

Number of Participants
6,191
Supplementary information about number of participants
6814 participants recruited in full MESA study, 6191 participants in MESA Neighborhood study
Baseline: 6191 participants
Follow-up 1: 6083 participants
Follow-up 2: 5920 participants
Follow-up 3: 5693 participants
Follow-up 4: 4637 participants

Data Collection Events

# Name Data sources Data sources - Biosamples Start End
0 MESA Neighbourhood - Baseline
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Geographic information system measures
  • Blood
  • Urine
2000 (July) 2002 (August)
1 MESA Neighbourhood - Follow-up 1
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Geographic information system measures
  • Blood
  • Urine
2002 (July) 2004 (February)
2 MESA Neighbourhood - Follow-up 2
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Geographic information system measures
  • Blood
  • Urine
2004 (January) 2005 (September)
3 MESA Neighbourhood - Follow-up 3
  • Questionnaires
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Geographic information system measures
  • Blood
2005 (September) 2007 (May)
4 MESA Neighbourhood - Follow-up 4
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
  • Administrative databases
  • Other : Geographic information system measures
  • Blood
  • Urine
2010 (April) 2012 (February)

Participating Studies

Acronym Name Study design Countries

Harmonization Initiatives Included

Acronym Name

Datasets

Name Data Collection Events Variables

Areas of Information Collected

Socio-demographic and economic characteristics
Death
Lifestyle and behaviours
Physical measures and assessments
Birth, pregnancy and reproductive health history
Laboratory measures
Perception of health, quality of life, development and functional limitations
Cognition, personality and psychological measures and assessments
Diseases
Life events, life plans, beliefs and values
Symptoms and signs
Preschool, school and work life
Medication and supplements
Social environment and relationships
Non-pharmacological interventions
Physical environment
Health and community care services utilization
Administrative information

Variables Content Summary

Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected

Networks

Acronym Name Harmonization Initiatives Individual Studies
Last Update: 2023-08-10T18:19:22.822