Oxidative stress, fetal growth and programming of the metabolic syndrome and cardiovascular disorders
The main objective of MIROS C study is to assess the association between indices of oxidative stress in the mothers and in the newborn and early indicators of programming of 1) cardiovascular disorders and 2) obesity or type 2 diabetes at 1 year of age.
Overview
- Acronym
- MIROS C
- Website
- MIROS C
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2006 - 2008
- General Information on Follow Up (profile, frequency)
-
After the baseline visit during their second trimester of pregnancy, participants were followed-up during their third trimester of pregnancy, at birth, 3 months postpartum and 12 months postpartum.
- Recruitment Target
-
- Families
- Number of Participants
- 614
- Number of Participants with Biological Samples
- 562
- Supplementary information about number of participants
-
Mothers: 307 participants
Children: 307 participants - Supplementary Information
-
Mothers: 248 participants
Children: 248 participants
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: Dr. Zhong-Cheng Luo (Université de Montréal)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
anonymization
Cost
| Possible Access to Data | Not yet defined |
| Possible Access to Biosamples | N/A |
Usually, open to collaboration
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Need REB approval from CHU Sainte-Justine (co-PI: Anne Monique Nuyt, William Fraser)
Marker Papers
Luo Zhong-Cheng, Bilodeau Jean-François, Nuyt Anne-Monique, Fraser William D., Julien Pierre, Audibert François, Xiao Lin, Garofalo Carole, Levy Emile. Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans.Scientific Reports 2015; 5: 17881.
PUBMED 26643495Timeline
Populations
MIROS C - Mothers
The population is composed of women who are 24-27 weeks pregnant of gestation and who bear a singleton fetus.
Selection Criteria
- Sex
-
Women only
- Minimum age
-
18
- Maximum age
-
45
- Pregnant Women
-
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal, Quebec
- Supplementary Information about selection criteria
-
- Exclusion criteria:
- Women <18 years or >45 years of age;
- Women who are illegal drugs users;
- Women with multiple pregnancies (twin or more fetuses);
- Fetuses or infants with known congenital anomalies or chromosomal abnormalities (e.g. Down syndrome);
- Mothers or infants with endocrine disorders: growth hormone deficiency, hyperthyroidism, hypothyroidism, or other known endocrine disorders;
- Mothers or infants with severe illnesses or life threatening conditions: renal failure, active or chronic liver diseases, epilepsy, collagen diseases, serious pulmonary disease, serious hematologic disorders, cancers, heart disease, or other life threatening conditions;
- Fetal or infants deaths (only expected 0 or 1 case within the recruited sample).
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Women were recruited in three hospitals in Montreal: Saint-Justine Hospital, General Jewish Hospital and Saint Mary's Hospital.
Sample Size
- Number of Participants
- 307
- Number of Participants with Biological Samples
- 307
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MIROS C - Mothers - Second trimester |
|
|
2006 (August) | 2008 (December) |
| 1 | MIROS C - Mothers - Third trimester |
|
|
2006 (September) | 2009 (January) |
| 2 | MIROS C - Mothers - Birth |
|
|
2006 (December) | 2009 (April) |
| 3 | MIROS C - Mothers - 3 months postpartum |
|
2007 (March) | 2009 (July) | |
| 4 | MIROS C - Mothers - 12 months postpartum |
|
2007 (December) | 2010 (April) |
MIROS C - Children
The population is composed of the children of the women enrolled in the study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Quebec
- Territory
- Montreal, Quebec
- Supplementary Information about selection criteria
-
- Exclusion criteria:
- Fetuses or infants with known congenital anomalies or chromosomal abnormalities (e.g. Down syndrome);
- Mothers or infants with endocrine disorders: growth hormone deficiency, hyperthyroidism, hypothyroidism, or other known endocrine disorders;
- Mothers or infants with severe illnesses or life threatening conditions: renal failure, active or chronic liver diseases, epilepsy, collagen diseases, serious pulmonary disease, serious hematologic disorders, cancers, heart disease, or other life threatening conditions;
- Infants with several asphyxia (cord arterial blood PH <7.05) or 5-minutes Apgar score <4 (such exposure may affect oxidative stress markers in cord blood samples);
- Fetal or infants deaths (only expected 0 or 1 case whitin the recruited sample).
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the women already recruited in the study
Sample Size
- Number of Participants
- 307
- Number of Participants with Biological Samples
- 255
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | MIROS C - Children - Birth |
|
2006 (December) | 2009 (April) | |
| 1 | MIROS C - Children - 3 months postpartum |
|
2007 (March) | 2009 (July) | |
| 2 | MIROS C - Children - 12 months postpartum |
|
|
2007 (December) | 2010 (April) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-04-29T11:45:50.996