Prenatal Determinants of Inflammation - mediated Conditions Transdisciplinary Research
The PreDICTR Study (Prenatal Determinants of Inflammatory-mediated Conditions Transdisciplinary Researh) aims to investigate the effects of intra-uterine inflammation on the occurrence of future disease in the offspring of that pregnancy.
Overview
- Acronym
- PreDICTR
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2010 -
- General Information on Follow Up (profile, frequency)
-
Phase 1: The mothers of the Pre-Conception cohort were followed-up within four weeks of conception, and in trimesters two and three.
The mothers of the Conception cohort were followed-up at each trimester.
The mothers of the High Risk Birth cohort were followed-up in their last trimester.
The children were followed-up at 6, 12 and 18 months of age.Phase 2: Phase 2 (2017) is designed to develop a panel of clinical and biomarker attributes that can predict and detect intra-uterine inflammation. Phase 2 will enroll only women in their first trimester and are deeded to have a pregnancy at high risk for inflammation (history of previous spontaneous abortions or premature deliveries, hypertension, obesity, associated inflammatory and/or autoimmune disease). Mothers will be assessed at enrollment and at labor and the offspring assessed at birth and at age 6 months.
- Recruitment Target
-
- Families
- Number of Participants
- 70
- Number of Participants with Biological Samples
- 70
- Supplementary information about number of participants
-
Mothers(4 sub-groups): 35 participants
Children: 35 participants - Supplementary Information
-
Pregnant women and the offspring of the current pregnancy were recruited in the study.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: Prof. Alan Rosenberg (University of Saskatchewan)
Timeline
Populations
PreDICTR - Mothers - Pre-Conception
The Pre-Conception cohort consists of women who intended to become pregnant within one year at the time of recruitment and who then became pregnant.
Selection Criteria
- Gender
-
Women only
- Countries
-
- Canada
- Canadian Provinces
-
- Saskatchewan
- Territory
- Saskatoon Health Region
- Other Criteria
- Women who intended to become pregnant within one year and became pregnant, had not used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as prenatal classes and media announcements).
Sample Size
- Number of Participants
- 15
- Number of Participants with Biological Samples
- 15
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PreDICTR - Mothers - Pre-Conception - Before conception |
|
2010 | 2013 | |
| 1 | PreDICTR - Mothers - Pre-Conception - First trimester of pregnancy |
|
|
2010 | 2013 |
| 2 | PreDICTR - Mothers - Pre-Conception - Second trimester of pregnancy |
|
|
2010 | 2013 |
| 3 | PreDICTR - Mothers - Pre-Conception - Third trimester of pregnancy/birth |
|
|
2010 | 2013 |
PreDICTR - Mothers - High Risk Birth
The High Risk Birth cohort consists of women who were in their last trimester of pregnancy at the time of recruitment and who had a high risk pregnancy (premature labour, history of premature labour, hypertension, gestational diabetes, obesity, intra-uterine infection, systemic or localised infection, underlying inflammatory/immune-mediated diseases or any other condition deemed by the primary care physician to be a high risk factor).
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- Third trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Saskatchewan
- Territory
- Saskatoon Health Region
- Other Criteria
- Women who had a high risk pregnancy, had to not have used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as pre-natal classes and media announcements).
Sample Size
- Number of Participants
- 6
- Number of Participants with Biological Samples
- 6
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PreDICTR - Mothers - High Risk Birth - Third trimester of pregnancy/birth |
|
|
2010 | 2013 |
PreDICTR - Mothers - Conception
The Conception cohort consists of women who were in their first trimester of pregnancy and who had a high risk pregnancy (premature labour, history of premature labour, hypertension, gestational diabetes, obesity, intra-uterine infection, systemic or localised infection, underlying inflammatory/immune-mediated diseases or any other condition deemed by the primary care physician to be a high risk factor).
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- First trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Saskatchewan
- Territory
- Saskatoon Health Region
- Other Criteria
- Women had to be at first trimester of pregnancy, had to not have used IVF (In-Vitro Fertilization treatment) and had not had a multiple-conceptus pregnancy.
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Prospective participants were made aware of the study by their primary care physician or obstetrician or through publicly-accessible notices (such as pre-natal classes and media announcements).
Sample Size
- Number of Participants
- 14
- Number of Participants with Biological Samples
- 14
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PreDICTR - Mothers - Conception - First trimester of pregnancy |
|
|
2010 | 2018 |
| 1 | PreDICTR - Mothers - Conception - Second trimester of pregnancy |
|
|
2010 | 2018 |
| 2 | PreDICTR - Mothers - Conception - Third trimester of pregnancy/birth |
|
|
2010 | 2018 |
PreDICTR - Children
This population consists of children of the women in the Pre-Conception, Conception and High Risk Birth cohorts included in the study.
Selection Criteria
- Newborns
- Countries
-
- Canada
- Canadian Provinces
-
- Saskatchewan
- Territory
- Saskatoon
Sources of Recruitment
- Specific Population
-
- Other specific population : Children of the women (from the Pre-Conception, Conception and High Risk Birth cohorts) participating in the study.
Sample Size
- Number of Participants
- 35
- Number of Participants with Biological Samples
- 35
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PreDICTR - Children - Birth |
|
|
2010 | 2018 |
| 1 | PreDICTR - Children - 6 months old |
|
|
2010 | 2018 |
| 2 | PreDICTR - Children - 12 months old |
|
2011 | 2019 | |
| 3 | PreDICTR - Children - 18 months old |
|
2011 | 2019 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T15:52:39.016