Early Pregnancy Markers for Pre-Eclampsia
The main objective of the Early Pregnancy Markers for Pre-Eclampsia study (PreMark) was to examine the relationship between homocysteine (tHcy) concentrations in early pregnancy and the subsequent development of gestational hypertension (GH) or preeclampsia, as well as the relationship between tHcy concentrations and pregnancy loss and small for gestational age (SGA) infants.
Overview
- Acronym
- PreMark
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 2002 - 2006
- General Information on Follow Up (profile, frequency)
-
Pregnant women were recruited prior to 20 weeks of pregnancy and were followed-up at their 20th week of gestation, as well as after delivery, until 2006.
- Recruitment Target
-
- Individuals
- Number of Participants
- 2,200
- Number of Participants with Biological Samples
- 2,200
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Dodds L, Fell DB, Dooley KC, Armson BA, Allen AC, Nassar BA, Perkins S, Joseph KS. 2008. Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes. Clinical Chemistry; 54(2): 326-34.
PUBMED 18070815Timeline
Population
PreMark - Mothers
The population is composed of pregnant women, with a gestational age of less than 20 weeks at the time of recruitment.
Selection Criteria
- Gender
-
Women only
- Pregnant Women
-
- First trimester
- Second trimester
- Countries
-
- Canada
- Canadian Provinces
-
- Nova Scotia
- Territory
- Halifax County
- Other Criteria
- Less than 20 weeks of gestation
Sources of Recruitment
- Specific Population
-
- Clinic patients
- Supplementary Information
-
Pregnant women who presented to the Blood Collection Services Laboratory at the Izaak Walton Killam Health Centre (IWK) for routine prenatal blood screening were invited to participate if their pregnancy was less than 20 weeks of gestation, based on self-report from the participants.
Sample Size
- Number of Participants
- 2,200
- Number of Participants with Biological Samples
- 2,200
- Supplementary information about number of participants
-
Recruitment < 20 weeks : 2200 women
Follow-up at 20th week : 2119 women
Follow-up at delivery: 2016 women
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | PreMark - Mothers - Less than 20 weeks |
|
|
2002 (October) | 2005 (July) |
| 1 | PreMark - Mothers - 20 weeks |
|
2002 (October) | 2005 (December) | |
| 2 | PreMark - Mothers - Delivery |
|
2003 (March) | 2006 (May) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2024-02-27T15:56:08.557