Religious Order Study
Researchers are using the information from the study to discover what changes in the brain are responsible for memory and movement problems. The study also looks closely at the transition from normal functioning of the aging brain to the mild cognitive impairment that can be an early sign of Alzheimer’s disease.
Overview
- Acronym
- ROS
- Investigators
-
- Contacts
-
General Design
- Study design
- Cohort
- Start - End Year
- 1994 -
- General Information on Follow Up (profile, frequency)
-
Annual follow-up
- Recruitment Target
-
- Individuals
- Number of Participants
- 1,200
- Number of Participants with Biological Samples
- 1,200
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Bennett DA, Schneider JA, Arvanitakis Z, Wilson RS. Overview and Findings from the Religious Orders Study. Curr Alzheimer Res. 2011; 9(6):628-645.
PUBMED 22471860Supplementary Information
The overall goal of this proposed renewal of the Rush Alzheimer's Disease Core Center (Rush ADCC) is to continue to provide an infrastructure to support cutting edge research on MCI, AD, and other dementias by providing researchers with clinical data and biologic specimens from persons with and without cognitive impairment for independently funded projects. The Rush ADCC has been in continuous operation since 1991. It has six Cores carefully designed to support a variety of timely and important areas of research including: 1) Studies of the neurobiology of MCI, AD, and other dementias; 2) Studies linking risk factors to ante-mortem and post-mortem indices of MCI, AD, and other dementias; 3) Studies with substantial participation by racial and ethnic minorities; and 4) Studies that facilitate the overall goals and mission of the Rush ADCC, the Alzheimer's Disease Centers program, and the AD research community. The six Rush ADCC cores are designed to achieve these overall goals. The Administrative Core provides scientific leadership to the ADCC as a whole. The Clinical Core collects data using the uniform data set procedures as designed and implemented by the AD Centers Clinical Task Force, and emphasizes careful follow-up and autopsy of racial and ethnic minorities, and persons with atypical dementias. The Religious Orders Study Core, begun in 1993, follows a group of more than 1000 older men and women members of Catholic religious communities who have agreed to annual detailed clinical evaluations and to brain donation at death. The Neuropathology Core stores obtains, processes, stores and evaluates ante-mortem and postmortem biologic specimens tissue in accordance with the Neuropathology Data Set defined by NACC from persons evaluated by the Clinical and Religious Orders Study Cores. The Education and Information Transfer Core provides a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical and Religious Orders Study Core. The Data Management and Biostatistics Core, begun in 1995, supplies computer systems for data acquisition and unified data management for all ADCC cores, biostatistical consultation both to the Cores and to investigators using Core data, and transfer of data to NACC and approved investigators outside the Rush ADCC utilizing the data and resource sharing policies in the Administrative Core.
Data/Bio-specimen Access: To apply for access to RADC data/tissue, please enter an electronic request at our website: https://www.radc.rush.edu/res/ext/home.htm.
Timeline
Population
ROS participants are all brothers, sisters, and priests in the Roman Catholic church.
Selection Criteria
- Minimum age
-
65
- Countries
-
- United States of America
- Health Status
-
- No dementia diagnosed before baseline
- Other Criteria
-
agree to annual follow-up and donation of brain, spinal cord, muscle and nerve upon death
Sources of Recruitment
- General Population
-
- Volunteer enrolment
- Specific Population
-
-
Other specific population :
members of religious order communities of the Catholic church
-
Other specific population :
Sample Size
- Number of Participants
- 1,200
- Number of Participants with Biological Samples
- 1,200
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | ROS - Baseline |
|
|
1997 (December) | 2013 (December) |
| 1 | ROS - Annual Follow-up visit |
|
|
1998 (November) | 2013 (December) |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|