Study of Asthma, Genes and the Environment
The main objectives of the SAGE Study were :
- to collect information about the home environment of children in Manitoba;
- to confirm the rate of asthma in Manitoban children and validate the tools used to diagnose asthma;
- to understand the differences in children's immune system that either predisposes or protects them from getting asthma;
- to explore genes that may play a role in children developing asthma; and
- to understand the relationship between genes and the environment in the development of asthma.
Overview
- Acronym
- SAGE
- Website
- SAGE
- Investigators
-
- Contacts
-
General Design
- Study design
- Case-control
- Start - End Year
- 2002 -
- General Information on Follow Up (profile, frequency)
-
After the baseline questionnaire, a subset of participants were recruited in a nested case-control study.
- Recruitment Target
-
- Individuals
- Number of Participants
- 723
- Number of Participants with Biological Samples
- 723
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
- By contacting the study representative: Dr. Allan Becker (Universities of Manitoba)
Sector of research
| Possible Access to Data | Possible Access to Biosamples | |
| Investigators from the public sector | ||
| Investigators from the private sector | ||
| Investigators from not-for-profit organization |
Transfer
| Possible Access to Data | Possible Access to Biosamples | |
| Can leave the study facility | ||
| Can leave the country |
Cost
| Possible Access to Data | Variable Cost |
| Possible Access to Biosamples | Variable Cost |
Cost reduction for co-analyses
| Possible Access to Data | |
| Possible Access to Biosamples |
Marker Papers
Kozyrskyj AL, HayGlass KT, Sandford AJ, Paré PD, Chan-Yeug M, Becker AB. 2009. A novel study design to investigate the early-life origins of asthma in children (SAGE study). Allergy; 64: 1185-1193.
PUBMED 19416140Timeline
Populations
SAGE - Children with asthma
The population is composed of children aged 7-8 years old (born in 1995) at the time of recruitment, who were identified as having asthma following the first questionnaire.
Selection Criteria
- Minimum age
-
7
- Maximum age
-
8
- Countries
-
- Canada
- Canadian Provinces
-
- Manitoba
- Territory
- Manitoba
- Health Status
-
- Diagnosed asthma
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Children born in 1995 were identified from the provincial healthcare registry.
Sample Size
- Number of Participants
- 246
- Number of Participants with Biological Samples
- 246
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SAGE - Baseline questionnaire |
|
2002 | 2002 | |
| 1 | SAGE - Nested case-control study |
|
|
2002 | 2005 |
SAGE - Children without asthma
The population is composed of children aged 7-8 years old (born in 1995) at the time of recruitment, who were identified as being free of asthma following the first questionnaire.
Selection Criteria
- Minimum age
-
7
- Maximum age
-
8
- Countries
-
- Canada
- Canadian Provinces
-
- Manitoba
- Territory
- Manitoba
- Health Status
-
- Healthy children or children with allergies but no asthma
Sources of Recruitment
- General Population
-
- Selected sample
- Supplementary Information
-
Children born in 1995 were identified from the provincial healthcare registry.
Sample Size
- Number of Participants
- 477
- Number of Participants with Biological Samples
- 477
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SAGE - Baseline questionnaire |
|
2002 | 2002 | |
| 1 | SAGE - Nested case-control study |
|
|
2002 | 2005 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
|---|
Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|
Last Update: 2022-07-15T13:46:35.400