Screening Across the Lifespan Twin Study
The SALT study was initiated in 1998, with the purpose of screening all twins in Sweden born before 1958 for most common complex diseases, regardless of the status of their twin partner. The extensive interview included questions about illnesses and health, medication use, occupation, education, and lifestyle factors.
Overview
- Acronym
- SALT
- Website
- SALT
- Investigators
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- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 1998 - 2010
- Recruitment Target
-
- Families
- Number of Participants
- 44,919
- Number of Participants with Biological Samples
- 18,061
- Supplementary Information
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Magnusson PK, Almqvist C, Rahman I, et al. The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments. Twin Res Hum Genet 2012; 16: 317-29. Pubmed ID 23137839.
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
|
Marker Paper
Lichtenstein P, Sullivan PF, Cnattingius S, et al. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet 2006; 9: 875-82.
PUBMED 17254424Supplementary Information
The Swedish Twin Registry (STR) includes more than 190,000 twins - in principle all twins born in Sweden since 1886. The STR is made of three cohorts, each of which differs in method of ascertainment and extent of data collected: old cohort (born between 1886-1925), middle cohort (born between 1926-1958), and young cohort (born between 1959-1990). Same-sex twins from the old cohort were sent questionnaires in 1961, 1963, 1967, and 1970, and those from the middle cohort were sent a questionnaire in 1973.
SALT is a sub-study of the STR and it is a complete screening of all twins from this registry, regardless of gender composition or vital status of the pair and stems from the old and middle cohorts. In addition to the SALT interview, there was the TwinGene (2004-2008), SALTY (2009-2010) which included questionnaires and biosamples, and HARMONY (1998-2003) which included cognitive functioning screenings for those 65 and above, which have been conducted.
Timeline
Population
The population consisted of twin pairs born in 1958 or earlier regardless of gender composition or vital status of the pair, selected from the Swedish Twin Registry and asked to participate to the study.
Selection Criteria
- Minimum age
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40
- Twins
- Countries
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- Sweden
Sources of Recruitment
- Specific Population
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- Other specific population : Swedish Twin Registry
Sample Size
- Number of Participants
- 44,919
- Number of Participants with Biological Samples
- 18,061
- Supplementary Information about selection criteria
-
HARMONY: 14 164
TwinGene: 12 614 participants
SALTY: 11 372 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | SALT - CATI interview |
|
1998 | 2002 | |
| 1 | SALT - HARMONY |
|
|
1998 | 2003 |
| 2 | SALT - TwinGene |
|
|
2004 | 2008 |
| 3 | SALT - SALTY |
|
|
2009 | 2010 |
Participating Studies
| Acronym | Name | Study design | Countries |
|---|
Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
Areas of Information Collected per per Population and Data Collection Event
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
|---|