Information is collected about sociodemographic characteristics (education, marital status, household income, household structure, occupation), lifestyle behaviours (nutrition, sports, leisure activities, sleep, means of transportation), behavioural risk factors (smoking, alcohol consumption), quality of life (Short-Form 36 Health Survey), reproductive history (for women only), family health history, diseases, injuries, health services utilization, medication, subjective well-being and mental health (Short-Form 12 Health Survey), cognitive functioning (Mini-Mental State Examination), social network, social contacts, workplace, housing, and neighbourhood environment. Neurological screening is conducted. Physical measures such as anthropometry (weight, height, BMI, body circumferences), blood pressure, electrocardiogram, body ultrasounds (heart, arteries, thyroid, liver), dental status and periodental status are collected. Blood and urine samples are collected.

Information on vital status is collected annually from Vital Statistics databases such as Death Registries.

Information is collected about morbidity annually through questionnaires, from the University Medicine Greifswald, the Association of Statutory Health Insurance Physicians, and dentists. Information is also collected about morbidity annually through Health databases.

Information is collected about sociodemographic characteristics (education, marital status, income, household structure, occupation), oral hygiene, physical activity, behavioural risk factors (smoking, alcohol consumption), diseases, injuries, health services utilization, medication, radioiodine therapy, traumatic life events and post-traumatic stress disorder, mental health (Composite International Diagnostic Interview), and cognitive functioning (Mini-Mental State Examination). Physical measures such as anthropometry (weight, height), blood pressure, electrocardiogram, ultrasounds (heart, artery, thyroid), endothelial funtion, pulmonary function, dental status and periodental status are collected. Blood and urine samples are collected.

Information was collected about positive and negative life events (Childhood Trauma Questionnaire), depression (Beck Depression Inventory II), personality (Life Orientation Test-Revised, Sense of Coherence Scale-Leipzig Short Scale, the Resilience Scale, NEO-Five-Factor Model, Toronto Alexithymia Scale, Coping Inventory for Stressful Situations), social support (Perceived Social Support Questionnaire), stress, and general health (12-Item Short Form Survey). An in-depth diagnostic interview for mental disorders was performed based on the Diagnostic and Statistical Manual for Mental Disorders (IV edition) diagnostic criteria.

Information is collected about sociodemographic characteristics (marital status, household income, household structure, occupation), lifestyle behaviours (nutrition, physical activity, leisure activities, sleep, means of transportation), behavioural risk factors (smoking, alcohol consumption), quality of life (EuroQol five dimensions questionnaire), reproductive history (for women only), diseases, injuries, health services utilization, medication, mental health (Composite International Diagnostic Interview), cognitive functioning (Mini-Mental State Examination), social contacts, and workplace environment (pressures and conditions at work). Physical measures such as anthropometry (weight, height, body circumferences), body impedance, blood pressure, electrocardiogram, ultrasounds (heart, artery, thyroid, liver, gallbladder, pancreas, and kidney), dermatological function, endothelial funtion, pulmonary function, bone stiffness, dental status, periodental status, and 3D body scan data are collected. Blood, stool, saliva, and urine samples are collected. Nose, mouth, and throat swabs are also collected.

Information is collected about sociodemographic characteristics (marital status, household structure, occupation), lifestyle behaviours (nutrition, physical activity, leisure activities, sleep), behavioural risk factors (smoking, alcohol consumption), quality of life (EuroQol five dimensions questionnaire), reproductive history (for women only), diseases, oral health, injuries, health services utilization, medication, mental health (Composite International Diagnostic Interview), cognitive functioning (Mini-Mental State Examination), social network and social support, and workplace environment (pressures and conditions at work). Physical measures such as anthropometry (weight, height, body circumferences), blood pressure, electrocardiogram, ultrasounds (heart, artery, thyroid, liver, gallbladder), pulmonary function, handgrip strangth, dental status, periodental status, and whole body magnetic resonance tomography imaging data are collected. Blood, urine, stool, and saliva samples are collected.

Information is collected about sociodemographic characteristics (marital status, household structure, occupation), lifestyle behaviours (nutrition, physical activity, leisure activities, sleep), behavioural risk factors (smoking, alcohol consumption), reproductive history (for women only), diseases, oral health, injuries, health services utilization, medication, mental health, cognitive functioning (Mini-Mental State Examination), social contacts. Physical measures such as anthropometry (weight, height, body circumferences), bioelectrical impedance, blood pressure, electrocardiogram, ultrasounds (heart, artery, thyroid, liver, gallbladder), pulmonary function, handgrip strangth, dental status, periodental status, 3d body scan, and whole body magnetic resonance tomography imaging data are collected. Blood, urine, stool, and saliva samples are collected.

Information is collected about sociodemographic characteristics (education, marital status, household income, household structure, occupation), lifestyle behaviours (nutrition, physical activity, sleep), behavioural risk factors (smoking, alcohol consumption), quality of life (EuroQol five dimensions questionnaire), oral health, women's health, family health history, diseases, injuries, visual functioning, health services utilization, treatments and interventions (medication, disease screening, surgeries), depression, childhood trauma (Childhood Trauma Questionnaire), cognitive function (Stroop Color and Word Test, Word List Memory Test), childhood trauma (Childhood Trauma Questionnaire), and social contacts, and hazardous workplace exposures. Physical measures such as anthropometry (weight, height, BMI, body circumferences), body composition (body impedance), circulatory health (blood pressure, electrocardiogram, echocardiogram, vascular ultrasound), skin health (dermatological examination), skeletal health (bone density), digestive health (liver ultrasound and dental examination), and diagnostic data (magnetic resonance tomography) are collected. Blood and urine samples are collected. Nose, mouth, and throat swabs are also collected.

Information on vital status is collected annually from Vital Statistics databases such as Death Registries.

Information is collected about morbidity annually through questionnaires and from the University Medicine Greifswald, the Association of Statutory Health Insurance Physicians, and dentists. Information is also collected about morbidity annually through Health databases.

Information is collected about sociodemographic characteristics (education, marital status, household income), lifestyle behaviours (nutrition, physical activity, leisure activities), behavioural risk factors (smoking, alcohol consumption), visual functioning, quality of life (EuroQol five dimensions questionnaire), oral health, women's health, diseases, injuries, health services utilization, medication, mental health (depression, post-traumatic stress disorder), cognitive function (Stroop Color and Word Test, Word List Memory Test), childhood trauma (Childhood Trauma Questionnaire), and social contacts. Physical measures such as anthropometry (weight, height, BMI, body circumferences), body impedance, circulatory health (blood pressure, electrocardiogram, echocardiogram, vascular ultrasound), grip strength, skin health (dermatological examination), digestive health (liver ultrasound and dental examination), and diagnostic data (magnetic resonance tomography) are collected. Blood, urine, stool, and saliva samples are collected. Nose, mouth, and skin swabs are also collected.

Information was collected about COVID-19 infections (infection status, symptoms), COVID-19 vaccinations, self-assessment of COVID-19 risk, agreement with pandemic measures, and expectations regarding the further course and effects of the pandemic. Information was also collected about depressive symptoms, quality of life, lifestyle changes, social and workplace environment, family, and attitudes toward ageing.

Information is collected about sociodemographic characteristics, addiction and risk behaviours, health behaviours, diseases, animal contacts (pets such as dogs, cats, poultry/pigeons), risk factors for zoonotic transmission, and animal husbandry. Physical measures include anthropometry, bioelectrical impedance, ultrasound scans (heart and other organs), dental status, periodontal status, eye movements and eye health, voice quality, gait, foot pressure, MRI and hand scan, pulmonary function test, a bicycle stress test, and daily activity (actimeter and GPS logger). Biosamples include hair and nail clippings.