Swiss Transplant Cohort Study
The main objectives of this study are to:
* Record all solid organ transplants (SOTs) within one unique database system in order to have a complete assessment of all patient-, transplant-, and center-specific activities in Switzerland.
* Prospectively collect high quality longitudinal clinical and laboratory data of transplant recipients at the Swiss national level, to evaluate the quality, effectiveness and efficiency of SOT in order to support patients, health care professionals and policy makers with informed decision-making.
* Implement a bio-bank sampling scheme to integrate biological and clinical information.
* Reflect the complexity of the post-transplant patient care in an appropriate data model and integrate this complexity into research hypothesis and methodology.
* Collect selected psychosocial and behavioral data at time of listing and during follow-up.
* Systematically capture relevant infectious diseases episodes.
* Record and periodically update specific risk profiles to reflect changes in disease- and treatment status.
* Assess determinants of poor short- or long-term outcome and allow studying alternative pathways that contribute to the understanding of patient – and allograft survival.
Overview
- Acronym
- STCS
- Website
- STCS
- Investigators
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- Contacts
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General Design
- Study design
- Cohort
- Start - End Year
- 2008 -
- General Information on Follow Up (profile, frequency)
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Follow-up assessments took place at 6 and 12 months and yearly thereafter. In the case of a second or re-transplantation, three extra assessments were performed of the new case at baseline, 6, and 12 months and the patient data in regard to the new case was updated.
- Recruitment Target
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- Individuals
- Number of Participants
- 6,311
Access
Availability of data and biosamples
| Possible Access to Data | |
| Possible Access to Biosamples | |
| Other |
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Marker Papers
Stampf S, Mueller NJ, van Delden C, et al. Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland. BMJ Open 2021;11:e051176.
PUBMED 34911712Koller MT, van Delden C, Müller NJ, et al. Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort. European Journal of Epidemiology. 2013. 28(4):347-55. Stampf S, Mueller NJ, van Delden C, et al. Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland. BMJ Open 2021;11:e051176.
PUBMED 23546766Supplementary Information
STCS is an internationally recognized research platform. STCS research data and samples are open to researchers. More than 200 projects are using STCS data.
van Delden C, Stampf S, Hirsch HH, e al. Burden and Timeline of Infectious Diseases in the First Year After Solid Organ Transplantation in the Swiss Transplant Cohort Study. Clinical Infectious Disease. 2020;71(7):e159-e169. PMID: 31915816
van Delden C, Stampf S, Hirsch HH, e al. Burden and Timeline of Infectious Diseases in the First Year After Solid Organ Transplantation in the Swiss Transplant Cohort Study. Clinical Infectious Disease. 2020;71(7):e159-e169. PMID: 31915816
Timeline
Population
STCS population
The population is composed of solid organ transplant recipients (including first, second of re-transplant cases) transplanted in Switzerland.
Selection Criteria
- Countries
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- Switzerland
- Health Status
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- Patients with grafts (solid organ) implanted since May 2008.
- Supplementary Information about selection criteria
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Participants were recruited at all six Swiss transplant centers involved in the study.
Sources of Recruitment
- Specific Population
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- Clinic patients
- Supplementary Information
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Tissue transplantations are not considered.
Sample Size
- Number of Participants
- 6,311
- Supplementary information about number of participants
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Renal transplant recipients: 3598 participants
Liver transplant recipients: 1386 participants
Lung transplant recipients: 564 participants
Heart transplant recipients: 469 participants
Kidney-pancreas transplant recipients: 133 participants
Kidney-liver transplant recipients: 55 participants
Islets transplant recipients: 40 participants
Kidney-islets transplant recipients: 23 participants
Kidney-heart transplant recipients: 14 participants
Pancreas transplant recipients: 13 participants
Other rare transplant scenarios: 16 participants
Pediatric transplant recipients: 326 participants
Data Collection Events
| # | Name | Data sources | Data sources - Biosamples | Start | End |
|---|---|---|---|---|---|
| 0 | STCS - Baseline |
|
|
2008 (May) | Ongoing |
| 1 | STCS - Follow-up 1 |
|
|
2008 (November) | Ongoing |
| 2 | STCS - Follow-up 2 |
|
|
2009 (May) | Ongoing |
| 3 | STCS - Follow-up 3 |
|
2010 (May) | Ongoing | |
| 4 | STCS - Follow-up 4 |
|
2011 (May) | Ongoing | |
| 5 | STCS - Follow-up 5 |
|
2012 (May) | Ongoing | |
| 6 | STCS - Follow-up 6 |
|
2013 (May) | Ongoing | |
| 7 | STCS - Follow-up 7 |
|
2014 (May) | Ongoing | |
| 8 | STCS - Follow-up 8 |
|
2015 (May) | Ongoing | |
| 9 | STCS - Follow-up 9 |
|
2016 (May) | Ongoing | |
| 10 | STCS - Follow-up 10 |
|
2017 (May) | Ongoing | |
| 11 | STCS - Follow-up 11 |
|
2018 (May) | Ongoing | |
| 12 | STCS - Follow-up 12 |
|
2019 (May) | Ongoing | |
| 13 | STCS - Follow-up 13 |
|
2020 (May) | Ongoing | |
| 14 | STCS - Follow-up 14 |
|
2021 (May) | Ongoing | |
| 15 | STCS - Follow-up 15 |
|
2022 (May) | Ongoing | |
| 16 | STCS - Follow-up 16 |
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2023 (May) | Ongoing |
Participating Studies
| Acronym | Name | Study design | Countries |
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Harmonization Initiatives Included
| Acronym | Name |
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Datasets
| Name | Data Collection Events | Variables |
|---|
Areas of Information Collected
- Socio-demographic and economic characteristics
- Death
- Lifestyle and behaviours
- Physical measures and assessments
- Birth, pregnancy and reproductive health history
- Laboratory measures
- Perception of health, quality of life, development and functional limitations
- Cognition, personality and psychological measures and assessments
- Diseases
- Life events, life plans, beliefs and values
- Symptoms and signs
- Preschool, school and work life
- Medication and supplements
- Social environment and relationships
- Non-pharmacological interventions
- Physical environment
- Health and community care services utilization
- Administrative information
Variables Content Summary
Areas of Information Collected
No Areas of Information Collected
No Scales Collected
Areas of Information Collected per per Population and Data Collection Event
No Areas of Information Collected
No Scales Collected
Networks
| Acronym | Name | Harmonization Initiatives | Individual Studies |
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Last Update: 2023-05-25T10:34:51.111