Information on sociodemographics (education, household income), lifestyle (diet, physical activity, drinking and smoking habits, electronic device use), psychosocial factors (mental health, social support), family history and early life exposures medication and health status were collected. Cognitive function data was also collected. Blood pressure, heart rate, grip strength, body composition, bone density, arterial stiffness, spirometry, and sight were also measured. A blood, saliva and urine sample were collected.

Information on sociodemographics (birthplace, employment, income, education, ethnicity), lifestyle (24-hour detailed diet recall, physical activity, sleep, drinking and smoking habits, electronic device use, sun exposure, sexual history), health status, psychosocial factors (mental health, social support), family health history, early life factors (adoption, part of a multiple birth, breastfed as a baby) health status and medical history were collected through questionnaires. Cognitive function data was also collected using touchscreen questionnaires (lights pattern and pairs matching memory, word production, snap reaction speed, and fluid-intelligence tests). Further, physical measures such as blood pressure, arterial stiffness, eye measures, hearing measures, body composition measures (including impedance), hand-grip strength, ultrasound bone densitometry, spirometry, and an exercise/fitness test with ECG were collected. Blood, saliva and urine sample were collected.

Information on the diet was collected by online 24-hour dietary recall questionnaire.

Information on sociodemographics (birthplace, employment, income, education, ethnicity), lifestyle (24-hour detailed diet recall, physical activity, sleep, drinking and smoking habits, electronic device use, sun exposure, sexual history), health status, psychosocial factors (mental health, social support), family health history, early life factors (adoption, part of a multiple birth, breastfed as a baby) health status and medical history were collected through questionnaires. Cognitive function data was also collected using touchscreen questionnaires (lights pattern and pairs matching memory, word production, snap reaction speed, and fluid-intelligence tests). Further, physical measures such as blood pressure, arterial stiffness, eye measures, hearing measures, body composition measures (including impedance), hand-grip strength, ultrasound bone densitometry, spirometry, and an exercise/fitness test with ECG were collected.

Information on physical activity was collected using a wrist-worn tri-axial accelerometer.

Participants’ health is obtained on a regular basis through linkage to death and cancer registries as well as hospital inpatient records. Information on cause-specific mortality, cancer and other diagnoses, COVID-19 outcomes, first occurrences of the diseases, operations and procedures plus dates are available.

Information was collected from a web questionnaire about cognitive function. Topics of the questionnaire included: mood, fluid intelligence, trail making, symbol digit substitution, pairs matching, and numeric memory.

Information was collected on occupational history, respiratory health and medication use for respiratory conditions; and smoking habits using web questionnaire.

Information on MRI brain, heart and abdomen, ultrasound of carotid arteries and whole body DXA scan of bones and joints, process completion time, durations and process authorisation data is collected.

Blood sample is collected

Information on as anxiety, depression, happiness and subjective well-being, mental distress, self-harm, traumatic events, unusual and psychotic experiences behaviours further other risk factors for mental health such as addictions, alcohol use and cannabis use was collected from a web questionnaire.

Information was collected from a web questionnaire about abdominal discomfort, chest pain, dizziness, coeliac disease or gluten sensitivity, family history of IBS, satisfaction with bowel habits, sensitive stomach and precisely a self-assessment of Irritable Bowel Syndrome (IBS).

Information was collected using a wrist-worn tri-axial accelerometer for a subset of participants. Participants were asked to repeat the exercise up to four times each on a quarterly basis to examine the influence of seasonal effects on the measurements.

Information was collected from a web questionnaire about experience of chronic pain: types, severity and duration, for all participants.

Information was collected from a web questionnaire about food preferences.

Information was collected about COVID-19 antibody self-test results, vaccination dates, hospitalization, and death. Blood samples were collected. Primary care information was collected through medical records.

Information on MRI brain, heart and abdomen, ultrasound of carotid arteries and whole body DXA scan of bones and joints, process completion time, durations and process authorisation data is collected.

Blood sample is collected